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All Journal Molekul: Jurnal Ilmiah Kimia Jurnal Informatika dan Kesehatan Jurnal Analis Kesehatan Kendari
Esti Badia
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Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Essential Oils of Alpinia monopleura and Their Antibacterial and Antioxidant Activity Agung Wibawa Mahatva Yodha; Esti Badia; Musdalipah Musdalipah; Muhammad Azdar Setiawan; Nur Saadah Daud; Angriani Fusvita; Adryan Fristiohady; Sahidin Sahidin
Molekul Vol 18 No 1 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.1.6265

Abstract

Alpinia monopleura is an endemic plant which widespread and abundant in Sulawesi. Nevertheless, previous studies have not studied the chemical compound and biological activity. This study describes the chemical compounds and antibacterial and antioxidant properties of the essential oils isolated from A. monopleura. The essential oil was obtained by the hydro distillation method and interpreted by GCMS. Antibacterial properties were determined by the agar diffusion method, while DPPH and ABTS determined antioxidant activity. The most important components are α-caryophyllene, β-pinene, limonene, α-pinene, β-caryophyllene and caryophyllene oxide. Essential oils of leaves and fruit showed excellent antibacterial properties with a MIC strength of 31.3 μg/mL against Staphylococcus aureus ATCC 25023 and Escherichia coli ATCC 35218. The highest antioxidant effect was also shown by inhibiting ABTS and DPPH radicals, with IC50 strength ​​of essential oil obtained from the leaf being 15.60 and 19.42 μg/mL, respectively, while from the fruit were 10.44 and 11.93 μg/mL. These antibacterial and antioxidant properties indicate that essential oils have advantages in their use in the food and pharmaceutical industries.
UJI EFEKTIVITAS EMULGEL ANTI JERAWAT EKSTRAK ETANOL DAUN JERUJU (Acanthus ilicifolius) TERHADAP Staphylococcus aureus rusli, Nirwati; Muh Azdar Setiawan; Yulianti Fauziah; Eny Nurhikmah; Esti Badia; Bonni Rubak; Riswanti Ruslan; Reymon; Isna Dwi Wulandari
Jurnal Analis Kesehatan Kendari Vol. 7 No. 2 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 7 (2) Juni 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46356/jakk.v7i2.350

Abstract

ABSTRACT The Jeruju plant is one of the true mangrove species that typically grows in coastal areas, rivers, swamps, and brackish water regions, and is used for medicinal purposes. Scientific data on Jeruju leaf (Achantus ilicifolious) extract indicate the presence of alkaloids, flavonoids, tannins, steroids, and saponins, all of which can be utilized for their antibacterial properties, particularly against the acne-causing bacterium Staphylococcus aureus. Staphylococcus aureus is known to cause skin blockages, which in turn trigger inflammation and the appearance of acne. The aim of this research was to determine whether an ethanol leaf extract emulgel of Jeruju (Achantus ilicifolious) could inhibit Staphylococcus aureus bacteria. The results of the study indicated that at a concentration of 10%, a inhibition zone of 3.8 mm was obtained, at 15% concentration it was 4.7 mm, and at 20% concentration it was 4.8 mm, categorizing the inhibition zones as weak (<5 mm).
Profil Histologi Pankreas pada Kemanjuran Ekstrak Purifikasi Batang Galing terhadap Diabetes yang Diinduksi Streptozotocin pada Tikus Model Diabetes Ilyas Y., Muhammad; Nuralifah; Dian Munasari Solo; Nirwati Rusli; Esti Badia
Jurnal Informatika dan Kesehatan Vol. 1 No. 2 (2024): IKN : Jurnal Informatika dan Kesehatan
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ikn.v1i2.3363

Abstract

The galing plant (Cayratia trifolia L.Domin), one of the endemic plants in Southeast Sulawesi, is proven to contain bioactive flavonoid, alkaloid, and tannin compounds that have various pharmacological effects such as anti-diabetes and strong antioxidants, especially the stem, so it has the potential to be developed as an alternative to diabetes treatment. However, scientific information about the effects of pancreatic organ repair in diabetes still needs to be scientifically proven. The purpose of this study was to reveal the role of purified extract of galing stem on the repair of pancreatic organs of streptozotocin-induced diabetic model white rats. This study is an experimental study, with a post-test design with a control group design using 18 male white rats divided into normal control groups (non-DM), negative control (DM + Na.CMC), positive control (DM + glibenclamide 0.018 mg/kg BW) and treatment samples (DM + purified extract of galing stem 400 mg/kg BW). The results of this study indicate that the administration of purified extract of galing stem is proven to be able to repair damage to the pancreas organs in diabetic model rats shown by the improvement of the morphology of the pancreatic beta cell structure and an increase in the number of endocrine cells in the islets of Langerhans compared to the negative control that was not treated with the extract so that these findings as new scientific data for the development of potential anti-diabetic drugs from galing plants.   ABSTRAK Tumbuhan galing (Cayratia trifolia L.Domin) salah satu  tumbuhan endemik di Sulawesi Tenggara terbukti mengandung senyawa bioaktif flavanoid, alkaloid dan tanin yang memiliki berbagai efek farmakologi seperti anti diabetes dan antioksidan kuat khususnya bagian batang, sehingga berpotensi dikembangkan sebagai alternatif penanganan penyakit diabetes, namun informasi ilmiah tumbuhan ini tentang efikasi pada perbaikan organ pankreas pada diabetes masih perlu dibuktikan secara ilmiah. Tujuan penelitian ini untuk mengungkap peran ekstrak purifikasi batang galing terhadap perbaikan organ pankreas tikus putih model  diabetes yang diinduksi streptozotocin. Penelitian ini adalah penelitian eksperimental, dengan desain rancangan post test with control group design menggunakan 18 ekor tikus putih jantan dibagi dalam kelompok kontrol normal (non DM), kontrol negatif (DM+Na.CMC), kontrol positif (DM+glibenklamid 0,018  mg/kg BB) dan perlakuan sampel (DM+ekstrak purifikasi batang galing 400 mg/kg BB). Hasil penelitian ini menunjukan bahwa pemberian ekstrak terpurifikasi batang galing terbukti dapat memperbaiki kerusakan organ pankreas pada tikus model diabetes yang ditunjukan adanya perbaikan morfologi struktur sel beta pangkreas dan terjadi peningkatan jumlah sel endokrin di pulau langerhans dibandingkan dengan kontrol negatif yang tidak diberi perlakuan ekstrak, sehingga temuan ini sebagai data ilmiah baru untuk pengembangan obat anti diabetes yang potensil dari tumbuhan galing.  
Co-Authors Adryan Fristiohady Angriani Fusvita Bonni Rubak Dian Munasari Solo Eny Nurhikmah Ilyas Y., Muhammad Isna Dwi Wulandari Muh Azdar Setiawan Muhammad Azdar Setiawan Musdalipah Musdalipah Nirwati Rusli Nur Saadah Daud Nuralifah Reymon Riswanti Ruslan Rusli, Nirwati Sahidin Sahidin Yodha, Agung Wibawa Mahatva Yulianti Fauziah