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Aktivitas Antibakteri Rimpang Meistera chinensis terhadap Bakteri Staphylococcus aureus ATCC 25023 dan Eschericia coli ATCC 35218 Secara Difusi Agar Karmilah; Reymon; Daud, Nur Saadah; Badia, Esti; Yodha, Agung Wibawa Mahatva; Setiawan, Muh. Azdar; Tee, Selfyana Austin; Musdalipah
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 8, No 1 (2023): February 2023
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v8i1.5651

Meistera chinensis merupakan generasi baru famili Zingiberaceae yang tumbuh di Sulawesi Tenggara. Ekstrak buah mengandung metabolit sekunder seperti flavonoid, terpenoid, alkaloid, steroid, dan tanin yang memiliki efektivitas sebagai antioksidan dan antibakteri. Namun, belum ada laporan tentang antibakteri pada bagian rimpang. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sekunder dan aktivitas antibakteri ekstrak etanol rimpang M. chinensis. Serbuk kering rimpang M. chinensis diekstraksi dengan maserasi menggunakan pelarut etanol 96%. Ekstrak dipekatkan menggunakan rotary vacuum evaporator. Metode analisis aktivitas antibakteri menggunakan difusi agar dengan konsentrasi ekstrak 10%, 20%, 30%, dan kontrol positif (Ciprofloxacin 30µg) terhadap Staphylococcus aureus ACTT 25023 dan Escherichia coli ACTT 35218 selama 24 jam. Hasil penelitian menunjukkan bahwa ekstrak etanol rimpang M. chinensis mengandung flavonoid, saponin, alkaloid, steroid, dan fenol, Ekstrak terbukti menghambat pertumbuhan E. coli dengan diameter zona hambat rata-rata secara berturut-turut pada konsentrasi 10%, 20%, dan 30% sebesar 6,08±1,79; 8,16±0,11 dan 10,57±1,34 mm. Pada S. aureus, zona hambat masing-masing konsentrasi 10%, 20%, dan 30% sebesar 5,02±0,79; 6,01±0,69; 8,03±0,76. Analisis One Way ANOVA menunjukkan perbedaan aktivitas antibakteri yang signifikan antar konsentrasi ekstrak pada E. coli dan S. aureus. Dapat disimpulkan rimpang M. chinensis memiliki aktivitas sebagai antibakteri.

POTENSI ANTIINFLAMASI EKSTRAK BATANG WUNDU WATU (Alpinia monopleura) TANAMAN ENDEMIK ASAL SULAWESI TENGGARA SECARA IN VITRO Musdalipah; Austin Tee, Selfyana; Wibawa Mahatva Yodha, Agung; Reymon; Azdar Setiawan, Muh.; Karmilah; Oktaviani, Santi
Jurnal Insan Farmasi Indonesia 2023: JIFI: Webinar & call for paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i3.1642

The wundu watu plant (Alpinia monopleura), is one of the endemic plants typical of Southeast Sulawesi which is commonly found in South Konawe Regency. The results of previous research on the essential oil content of the leaves and fruit of wundu watu are Î±-caryophyllene, Î²-pinene, limonene, Î±-pinene, Î²-caryophyllene and caryophyllene oxide. The essential oils of the leaves and fruit show antibacterial, antioxidant and anti-inflammatory properties. Pharmacological studies of this plant are not widely known, especially its efficacy as an anti-inflammatory. The purpose of this study was to determine the anti-inflammatory potential of extracts and fractions of wundu watu stem against inhibition of protein denaturation in Vitro. Wundu watu stem extract was extracted by maceration method using methanol solvent and ethyl acetate fraction. Anti-inflammatory testing using the protein denaturation inhibitor method using bovine and albumin and measured on a UV-Vis Spectrophotometer at a wavelength of 660 nm. The results showed that the extract and ethyl acetate fraction of wundu watu stem had anti-inflammatory activity with IC50 values of 10.59 mg/L and 2.02 mg/L. Based on the test results, it can be concluded that the stem extract of wundu watu has anti-inflammatory potential against protein denaturation with a very strong category.

Secondary Metabolite Compounds from Alpinia monopleura Extract and Evaluation of Anti-Inflammatory Activity based on In Vitro and In Silico Studies Yodha, Agung Wibawa Mahatva; Badia, Esti; Musdalipah; Reymon; Fauziah, Yulianti; Fusvita, Angriani; Arfan; Wahyuni; Sahidin
HAYATI Journal of Biosciences Vol. 31 No. 6 (2024): November 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.6.1154-1164

Alpinia monopleura is one of the endemic plants of Sulawesi, and it has an extensive distribution in the region. Research on chemical compounds and biological activities of A. monopleura is essential to continue as an effort to support the utilization of native plants for medicine. The extract was obtained using the maceration method. The chemical compounds in the extract were identified using Liquid Chromatography Mass Spectrometry (LCMS). Bovine Serum Albumin (BSA) and molecular docking methods were used to evaluate the anti-inflammatory activity. Ten compounds contained in the extract were successfully identified, E-para-coumaric acid (1), trans-ferulaldehyde (2), 3,5,6-trihydroxy-4',7-dimethoxyflavone (3), nevadensin (4), malvalic acid (5), ent-16α,17-hydroxy-19-kauranoic acid (6), 3′,5-dihydroxy-7,4'-dimethoxy flavone (7), saurufuran B (8), 5-hydroxy-7,8,2'-trimethoxyflavanone (9) and dehydroabietic acid (10). The anti-inflammatory activity of extracts from rhizomes and stems of A. monopleura were 8.62 and 10.59 mg/L, respectively. Some flavonoids (9 and 7) can bind strongly to specific residues around the COX-2 active site, such as Ser530, thereby interfering with the function of the COX-2 enzyme and reducing the production of pro-inflammatory prostaglandins. Thus, A. monopleura extract has the potential to inhibit inflammatory responses through molecular regulation of the COX-2 enzyme.

Korelasi Indeks Eritrosit Dan Red Cell Distribution Width (RDW) Pada Pasien Gagal Ginjal Kronik di Instalasi Hemodialisa RSUD Bahteramas Bonni Rubak; Susanti; Reymon; Sendy Ramadhany
Jurnal Analis Kesehatan Kendari Vol. 7 No. 2 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 7 (2) Juni 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46356/jakk.v7i2.349

Chronic kidney failure (CKD) is a disease condition that progressively occurs with a slow decline in kidney function that cannot return to normal, so that in advanced stages it requires replacement therapy such as hemodialysis. One of the most common complications in patients with CKD is anemia. This anemia is usually caused by reduced production of erythropoietin hormone which causes a shortening of erythrocyte lifespan. To evaluate the characteristics of anemia in chronic kidney failure (CKD) patients, hematological examination of erythrocyte indices, including Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), and Mean Corpuscular Hemoglobin Concentration (MCHC), as well as Red Cell Distribution Width (RDW), are performed. This study aims to determine the correlation between erythrocyte indices (MCV, MCH, and MCHC) and Red Cell Distribution Width (RDW) in CKD patients undergoing hemodialysis at Bahteramas Hospital. The study was conducted descriptively analytically with accidental sampling method of 77 CKD patients. The results of statistical analysis using the chi-square test showed a significant value in the MCV examination and RDW value of 0.000 under the p value <0.05, MCH examination and RDW value found a significant value of 0.000 under the p value <0.05, and MCHC examination and RDW value found a significant value of 0.000 under the p value <0.05. This shows that there is a statistically significant relationship between erythrocyte index and RDW value in CKD patients in the Hemodialysis Installation at Bahteramas Hospital.

UJI EFEKTIVITAS EMULGEL ANTI JERAWAT EKSTRAK ETANOL DAUN JERUJU (Acanthus ilicifolius) TERHADAP Staphylococcus aureus rusli, Nirwati; Muh Azdar Setiawan; Yulianti Fauziah; Eny Nurhikmah; Esti Badia; Bonni Rubak; Riswanti Ruslan; Reymon; Isna Dwi Wulandari
Jurnal Analis Kesehatan Kendari Vol. 7 No. 2 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 7 (2) Juni 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46356/jakk.v7i2.350

ABSTRACT The Jeruju plant is one of the true mangrove species that typically grows in coastal areas, rivers, swamps, and brackish water regions, and is used for medicinal purposes. Scientific data on Jeruju leaf (Achantus ilicifolious) extract indicate the presence of alkaloids, flavonoids, tannins, steroids, and saponins, all of which can be utilized for their antibacterial properties, particularly against the acne-causing bacterium Staphylococcus aureus. Staphylococcus aureus is known to cause skin blockages, which in turn trigger inflammation and the appearance of acne. The aim of this research was to determine whether an ethanol leaf extract emulgel of Jeruju (Achantus ilicifolious) could inhibit Staphylococcus aureus bacteria. The results of the study indicated that at a concentration of 10%, a inhibition zone of 3.8 mm was obtained, at 15% concentration it was 4.7 mm, and at 20% concentration it was 4.8 mm, categorizing the inhibition zones as weak (<5 mm).

Aktivitas Antibakteri Rimpang Meistera chinensis terhadap Bakteri Staphylococcus aureus ATCC 25023 dan Eschericia coli ATCC 35218 Secara Difusi Agar Karmilah; Reymon; Daud, Nur Saadah; Badia, Esti; Yodha, Agung Wibawa Mahatva; Setiawan, Muh. Azdar; Tee, Selfyana Austin; Musdalipah
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 8, No 1 (2023): February 2023
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v8i1.5651

Meistera chinensis merupakan generasi baru famili Zingiberaceae yang tumbuh di Sulawesi Tenggara. Ekstrak buah mengandung metabolit sekunder seperti flavonoid, terpenoid, alkaloid, steroid, dan tanin yang memiliki efektivitas sebagai antioksidan dan antibakteri. Namun, belum ada laporan tentang antibakteri pada bagian rimpang. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sekunder dan aktivitas antibakteri ekstrak etanol rimpang M. chinensis. Serbuk kering rimpang M. chinensis diekstraksi dengan maserasi menggunakan pelarut etanol 96%. Ekstrak dipekatkan menggunakan rotary vacuum evaporator. Metode analisis aktivitas antibakteri menggunakan difusi agar dengan konsentrasi ekstrak 10%, 20%, 30%, dan kontrol positif (Ciprofloxacin 30µg) terhadap Staphylococcus aureus ACTT 25023 dan Escherichia coli ACTT 35218 selama 24 jam. Hasil penelitian menunjukkan bahwa ekstrak etanol rimpang M. chinensis mengandung flavonoid, saponin, alkaloid, steroid, dan fenol, Ekstrak terbukti menghambat pertumbuhan E. coli dengan diameter zona hambat rata-rata secara berturut-turut pada konsentrasi 10%, 20%, dan 30% sebesar 6,08±1,79; 8,16±0,11 dan 10,57±1,34 mm. Pada S. aureus, zona hambat masing-masing konsentrasi 10%, 20%, dan 30% sebesar 5,02±0,79; 6,01±0,69; 8,03±0,76. Analisis One Way ANOVA menunjukkan perbedaan aktivitas antibakteri yang signifikan antar konsentrasi ekstrak pada E. coli dan S. aureus. Dapat disimpulkan rimpang M. chinensis memiliki aktivitas sebagai antibakteri.

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