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All Journal Padjadjaran Journal of Dentistry MDJ (Makassar Dental Journal)
Asdar Gani, Asdar
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Autologous stem cell regeneration therapy: a new hope for diabetes mellitus patients with periodontal defects : Terapi regenerasi autologus stem sel: suatu harapan baru bagi penderita diabetes melitus dengan defek periodontal Puspitasari, Rachmawati Dian; Gani, Asdar
Makassar Dental Journal Vol. 13 No. 3 (2024): Volume 13 Issue 3 Desember 2024
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v13i3.1196

Abstract

Several studies have been conducted on the use of autologous stem cells derived from the patient's own body as a therapeutic agent to increase the speed of healing and regeneration of periodontal defects due to periodontitis, including in patients with sys-temic diseases such as diabetes mellitus (DM). This literature review discusses the application and clinical effectiveness of auto-logous stem cells as regeneration therapy in DM patients with periodontal defects, the long-term effects and advantages and disadvantages of this regeneration therapy. This literature search is based on electronic data such as Pubmed, Wiley, Google Schoolar using several keywords. Periodontal ligament stem cells are adult stem cells that can be applied directly to repair perio-dontal defects. Direct local injection of stem cells may be an effective approach for periodontal regeneration in patients with DM. It is concluded that stem cells have the potential to be used in tissue regeneration and engineering. Some of the main advanta-ges of stem cells are their high differentiation ability and proliferation rate, relatively simple extraction and culture for use in auto-logous cell therapy in DM patients with periodontal defects.
Demineralized dentin matrix (DDM) from human teeth increases osteoblasts and type i collagen density after tooth extraction: an experimental study Dewi, Renie Kumala; Oktawati, Sri; Gani, Asdar; Suhartono, Eko; Hamrun, Nurlinda; Ganesh, Rajendran; Sapphira, Nadira; Aurenada, Syabita
Padjadjaran Journal of Dentistry Vol 37, No 1 (2025): March 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no1.59205

Abstract

Introduction: Post-extraction cavities must be promptly treated to minimize alveolar ridge resorption. Various bone graft materials can be used to encourage bone regeneration in perialveolar defects. Demineralized Dentin Matrix (DDM) is a bone graft material found in human tooth dentin containing type I collagen. The content of DDM is expected to show an increase in mediators that form bone, such as osteoblasts, thereby accelerating the bone healing process. The study aims to analyze the effect of DDM on osteoblast count and type I collagen density during post-extraction bone healing. Methods: This true experimental study used guinea pigs with extracted left mandibular incisors. Sockets were filled with (1) polyethylene glycol gel (control group, n=9) or (2) DDM gel (treatment group, n=9). The gel was inserted into the socket until it was full and then sutured with non-absorbable silk. The guinea pigs were euthanized on days 7, 14, and 21 for osteoblast counting and type I collagen density measurement. One-way ANOVA was used to assess osteoblast numbers, while the Kruskal-Wallis test was applied to analyze type I collagen density. Results: The treatment group exhibited a higher osteoblast count on day 7 (48.73), day 14 (79.00), and day 21 (89.66) compared to the control group (day 7: 33.00, day 14: 59.6, day 21: 78.27). A statistically significant difference was observed between the treatment and control groups in osteoblast count (p = 0.000) and type I collagen density (p = 0.009). Conclusion: DDM increases osteoblast numbers and type I collagen density on days 7, 14, and 21 post-extraction, potentially enhancing bone remodeling
The impact of chitosan derived from black soldier fly (Hermetia illucens) pupae on bone remodeling post-tooth extraction: an in vivo study Maula, Ni’mal; Waty, Marsela Umbar; Dewi, Renie Kumala; Oktawati, Sri; Gani, Asdar; Suhartono, Eko; Ganesh, Rajendran
Padjadjaran Journal of Dentistry Vol 37, No 1 (2025): March 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no1.59308

Abstract

Introduction: Bone defects or alveolar sockets commonly occur after tooth extraction. Black Soldier Fly (BSF) pupae contain 35% chitin, which can be converted into chitosan. This study aims to analyze the effect of BSF pupae chitosan gel on the number of osteoblasts and osteoclasts in post-extraction sockets. Method: This study employed a true experimental design. The left mandibular incisor of guinea pigs was extracted. In the control group (n=9), the socket was filled with polyethylene glycol (PEG) gel as a placebo, while in the treatment group (n=9), the socket was filled with BSF pupae chitosan  gel. The gel was applied until the socket was full, followed by suturing with non-absorbable silk. Euthanasia was performed on days 7, 14, and 21 to evaluate the number of osteoblasts and osteoclasts. Data were analyzed using one-way Anova. Results: The osteoblast count in the treatment group increased on day 7 (52.20 ± 1.90), day 14 (91.53 ± 1.00), and day 21 (104.13 ± 5.33) compared to the control group:  day 7 (39.80 ± 5.43), day 14 (61.13 ± 1.10), and day 21 (82.60 ± 2,11). The number of osteoclasts decreased in both groups: in the control group on day 7 (9.83 ± 0.35), day 14 (12.80 ± 0.72), and day 21 (2.46 ± 0.11); and in the treatment group on day 7 (4.86 ± 1.51), day 14 (9 ± 0.34), and day 21 (2.66 ± 0.11). Statistical analysis revealed significant differences in osteoblast and osteoclast counts between the treatment and control groups (p = 0.000). Conclusion: The application of chitosan BSF pupae gel can increase osteoblast numbers and decrease osteoclast numbers after tooth extraction, potentially accelerating bone formation and offering benefits for future bone regeneration.
Profile of periodontal disease associated by diabetes mellitus, hypertension, asthma in RSGMP Hasanuddin University year 2023-2024: Profil penyakit periodontal disertai diabetes melitus, hipertensi, asma di RSGMP Universitas Hasanuddin tahun 2023-2024 Ramadhani, Atikah Dhiya; Djulianra, Dzaky Sabrina; Nur, Syeck Jabal; Gani, Asdar; Adam, Mardiana; Hasanuddin; Oktawati, Sri; Djais, Arni Irawaty; Supiaty
Makassar Dental Journal Vol. 14 No. 3 (2025): Volume 14 Issue 3 December 2025
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v14i3.1268

Abstract

The purpose of this study was to determine the profile of periodontal disease in patients with diabetes mellitus, hypertension, and asthma at RSGMP Hasanuddin University in 2023-2024. The type of research used is quantitative research with descriptive re-search design with cross-sectional study design. The study was conducted on periodontal disease patients suffering from DM, hypertension, and asthma who came to RSGMP Unhas in 2023. The results of the study found 2048 patients with periodontal disease at RSGMP Unhas in 2023. Female gender was found to be more common, namely 1319 patients (54.78%) and male patients as many as 1089 (45.22%). The frequency distribution of periodontal disease accompanied by DM, male sex as many as 8 (5%) patients and female 8 (5%) patients, for the distribution of hypertension in female patients found as many as 17 people (47.22%) while in male patients found as many as 19 people (52.77%). Asthma patients, male gender as many as 1 patient (0.25%) and female 3 patients (0.75%). Conclusion The frequency distribution of periodontal disease accompanied by DM and hypertension most often found chronic periodontitis. And for asthma patients, periodontal diseases found were chronic periodontitis, gingival enlargement, irreversible pulpitis and apical abscess.
Co-Authors Adam, Mardiana Arni Irawaty Djais, Arni Irawaty Aurenada, Syabita Dewi, Renie Kumala Djulianra, Dzaky Sabrina Eko Suhartono Ganesh, Rajendran Hamrun, Nurlinda Hasanuddin Maula, Ni’mal Nur, Syeck Jabal Puspitasari, Rachmawati Dian Ramadhani, Atikah Dhiya Sapphira, Nadira Sri Oktawati, Sri Supiaty Waty, Marsela Umbar