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Ananta Choudhury, Ananta

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Author-ID : 639556

Medicine & Pharmacology

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Formulation design and in vitro evaluation of metformin hydrochloride transdermal film using hydrophilic polymer Sinha, Neman; Gupta, Suchita; Choudhury, Ananta
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

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The purpose of the experimental study was to design a sustained release film formulation of metformin hydrochloride. In this study a transdermal film has been prepared by incorporating hydrophilic polymers like HPMC and PVA in combination of different ratios. The prepared film were subjected for different evaluation parameters like swelling index study, surface pH, drug content analysis, thickness of film, folding endurance study, drug release study. Results of evaluation of all the film was found satisfactory. Again further study needs to be conducted to stabilize the formulations

Effect of solubilization technique on dissolution Das, Sujoy; Bahadur, Sanjib; Choudhury, Ananta; Saha, Suman
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

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More than 40 percent of newly discovered drugs have little or no water solubility thus the present research aimed at the study of improvement of solublisation on dissolution by addition of different solublising agents and modification of methods. Irbesartan is the drug of choice. Effect of Solubility on dissolution was studied with some solubilizing agents like β-Cyclodextrins, PEG-6000, Polysorbate-80, Cremophore and Resins (Doshion). It was seen that Irbesartan give 90 percent release in 1hr with polysorbate-80 where cremophore containing tablets showed 97 % release in 1 hr in case of solid dispersion technique and in case of complexation technique respectively. Thus the present study concluded that, dissolution rate of poorly soluble drug can be increases by using solubilizing agent as well as using different techniques

Phytosome: a novel dosage form for herbal drug delivery Choudhury, Ananta; Verma, Swati; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 2 No. 2 (2014)
Publisher : Creative Pharma Assent

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Phytosome is a complex of a natural active ingredient and phospholipids. The term ‘Phyto’ means plant while ‘some’ means cell like structure. It is claimed that phytosome increases absorption of "conventional herbal extracts" or isolated active principles both orally as well as topically. In this era phytosome gain popularity as a potential drug delivery device due to excessive demand and utility of herbs or herb based medicines. This advance technology offers amenities like improved absorption, enhanced delivery & increased bioavailability of herbal extracts. These drug-phospholipid complexes can be fabricated in the form of solution, suspension, emulsion, syrup, lotion, gel, cream, aqueous micro dispersions. Standardized plant extracts, mainly polar phytoconstituents like flavonoids, terpenoids, tannins, xanthones shall be introduced in form of phytosome.

Development and characterization of topical phyto-formulation for antifungal activity Choudhury, Ananta; Verma, Reema; Sinha, Devnarayan; Sahu, Saurabh; Roy, Am
Journal of Applied Pharmaceutical Research Vol. 2 No. 2 (2014)
Publisher : Creative Pharma Assent

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The present study was aimed to develop a potent antifungal topical gel using Curcumin and fluconazole in suitable combination. In these studies we have prepared different gel formulations using polymer like carbapol, Hydroxy propylmethyl cellulose, as well as excepients like tri-ethanolamine, methanol, glycerin and purified water. The formulated gel were evaluated in context of different parameters like drug content, pH, spreadability viscosity , in-vitro drug release , anti-microbial effect etc. Candida albicans was used as a model fungus to evaluate the antifungal activity of the prepared formulations.

Formulation and evaluation of enteric coated microcapsules of diclofenac sodium for modified release by combination of wet granulation and thermal change method Bahadur, Sanjib; Baghel, Pragya; Chanda, Ranabir; Roy, Amit; Saha, Suman; Choudhury, Ananta
Journal of Applied Pharmaceutical Research Vol. 2 No. 4 (2014)
Publisher : Creative Pharma Assent

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The purpose of the present work was to develop optimized novel enteric microcapsules containing diclofenac sodium, a non steroidal anti inflammatory drug (NSAID) used for rheumatoid arthritis, for improved delivery and to diminish its adverse effect after oral administration. The microcapsule was prepared by using different polymers and the enteric coating was provided by using an innovative technique combining wet granulation method and thermal change method. This work also investigated different levels of enteric polymers like cellulose acetate phthalate (CAP) (X1) and ethyl cellulose (EC) (X2) and the stirring speed during coating ethyl cellulose (X3), by using 23 full factorial design. The dependent variables assessed were % yield (Y1), Q8 (% drug released after 8 hour) (Y2), n (Diffusion coefficient) (Y3), DEE (Drug entrapment efficiency) (Y4). The main effect and interaction terms were quantitatively evaluated using a mathematical model. The prepared microcapsules were evaluated for percentage drug dissolved, scanning electron microscopy, drug excipient interaction, angle of repose, particle size. Mean dissolution time (MDT) was used to compare dissolution patterns obtained. The results showed that X1 and X2 significantly affected the release properties.

Pharmacological screening of Alsotonia scholaris Rathor, Vinod; Wadhwa, Shailendra; Deb, Jyotirmoy; Choudhury, Ananta
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
Publisher : Creative Pharma Assent

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A large number of medicinal plants are claimed to possess anthelmintic property in traditional systems of medicine and are also utilize by ethnic groups worldwide. The development of anthelmintic resistance and the high cost of conventional anthelmintic drugs led to the evaluation of medicinal plant as an alternative source of anthelmintice. In the current study were conducted to determine the possible anthelmintic and antibacterial effects of leaves of Alstonia scholaris. The plant Alstonia scholaris has been used in different system of traditional medication for the treatment of diseases and ailments of human beings including anthelmintic activity.

Bio-medical waste management in different hospitals of Guwahati and its effect on environment Changmai, Arabinda; Islam, Tofiqul; Nongsiang, Dibarlan; Deka, Manoj Kumar; Saharia, Bhargab Jyoti; Choudhury, Ananta; Dey, Biplab K.
Journal of Applied Pharmaceutical Research Vol. 6 No. 1 (2018)
Publisher : Creative Pharma Assent

Biomedical waste may be defined as the waste which is produced during the diagnosis, research activities, treatment of patients, treatment of animals, production and testing of biological product and including articles as mentioned in schedule I of the Biomedical Waste (Management and handling) (second amendment) Rules 2000, as per Ministry of Environment and Forests notification. Proper treatment, handling, and disposal of biomedical wastes is essential for healthcare infection control program. There may be a high risk of infections in patients due to the poor management of biomedical waste which can lead to antibiotic resistance. It is not only the health of the patient, but also the health of persons who are associated with health care industry equally important. This article speaks about how the hospitals present in Guwahati treat their waste material and the effect of the waste in the environment

Pharmacognostical, phytochemical and anthelmintic activity of Polygonum muricatum Goswami, Priyanka; Islam, Rajibul; Khongmalai, Everlasting; Sarkar, Bapi Ray; Sen, Saikat; Choudhury, Ananta; Dey, Biplab Kumar
Journal of Applied Pharmaceutical Research Vol. 6 No. 3 (2018)
Publisher : Creative Pharma Assent

Polygonum muricatum is widely used by the local people of Meghalaya for anthelmintics. An attempt has been made to evaluate the pharmacognostical, preliminary phytochemical and pharmacological parameters of leaves of Polygonum muricatum. The physicochemical constants like moisture content, ash values such as total ash, acid insoluble ash and water soluble ash, extractive values such as water soluble extractive value and alcohol soluble extractive value were determined. The extract obtained by successive solvent extraction was subjected to preliminary phytochemical analysis to find out the presence of compounds. The plant Polygonum muricatum leaves were extracted with the solvent benzene, acetone, ethanol and water by soxhlet apparatus method. The extract was evaluated for anthelmintic activity with Indian earthworm. Ethanol extract of the plant Polygonum muricatum has shown the significant activity.

Microsphere: a promising approach for drug delivery Choudhury, Ananta; Deka, Debasish; Sonowal, Kashmiri; Laskar, Rahela Eyachmin
Journal of Applied Pharmaceutical Research Vol. 7 No. 2 (2019)
Publisher : Creative Pharma Assent

The recent evolution in new drug delivery systems plays a important role in pharmaceutical industries. There are various controlled release products, Microsphere is one among all due to the sustained release and controlled release properties.Microsphere are small spherical shape characteristically free flowing powders, with diameters typically ranging from 1 μm to 1000 μm (1 mm). Microspheres can be produced using several natural and synthetic polymeric materials. Depending on the method, solid or porous microspheres can be obtained for specific intended applications. The variety of methods for the production of microspheres offers numerous opportunities to control the aspects of administration of the API. It provides the prolonged therapeutic action and reduce the dosing frequency, which improve the patient compliance. To get the desired effect the drug should deliver at the target tissue in an ideal amount in the right period of time with maximum therapeutic effect and minimum side effect. Now a day’s microspheres have been used to deliver drugs, vaccines etc. The article is mainly focus on the various aspect of microspheres drug delivery system along with their method of preparation, technique to evaluate its efficiency and pharmaceutical application of microspheres.

Floating drug delivery system: an outlook Choudhury, Ananta; Renthlei, Lalmalsawmi; Dewan, Manjima; Ahmed, Raju; Barakoti, Himal; Dey, Biplab Kumar
Journal of Applied Pharmaceutical Research Vol. 7 No. 3 (2019)
Publisher : Creative Pharma Assent

Floating drug delivery is considered as the most effective amongst the several approaches of gastro retentive drug delivery systems. The short gastric residence times (GRT) and unpredictable gastric emptying times (GET) are the two most important parameters that play a vital role in improving the bioavailability of drugs those are having an absorption window at the stomach. The floating drug delivery approach is a low-density system that may be effervescent or Non-Effervescent type with sufficient buoyancy to flow over the gastric contents and remain buoyant in the stomach without affecting the stomachic emptying rate for a prolonged duration. Floating dosage forms include tablets, granules, capsules, microspheres, microparticle, etc. are few formulations available commercially. A comprehensive summary of different floating drug delivery and its present status has been highlighted in this review.

Co-Authors Ahmed, Raju Amit Roy, Amit Baishya, Dhiraj Barakoti, Himal Basak, Ankita Changmai, Arabinda Changmai, Arabinda Deka, Debasish Deka, Himangshu Deka, Manoj Kumar Deka, Manoj Kumar Devnarayan Sinha, Devnarayan Dewan, Manjima Dey, Biplab K. Dey, Biplab Kumar Dey, Biplab Kumar Ganguly, Debgopal Garain, Soukat Ghosh, Riya Ghosh, Soumyadip Goswami, Priyanka Goswami, Priyanka Hoque, Nurjamal Islam, Rajibul Islam, Rajibul Islam, Tofiqul Islam, Tofiqul Jyotirmoy Deb, Jyotirmoy Khongmalai, Everlasting Khongmalai, Everlasting Laskar, Rahela E Laskar, Rahela Eyachmin Neman Sinha, Neman Nongsiang, Dibarlan Nongsiang, Dibarlan Pragya Baghel, Pragya Ranabir Chanda, Ranabir Reema Verma, Reema Renthlei, Lalmalsawmi Roy, Am Saharia, Bhargab Jyoti Saharia, Bhargab Jyoti Sanjib Bahadur, Sanjib Sarkar, Bapi Ray Sarkar, Bapi Ray Sarkar, Snehashis Sarmah, Jahnabi Saurabh Sahu, Saurabh Sen, Saikat Sen, Saikat Shailendra Wadhwa, Shailendra Sonowal, Kashmiri Suchita Gupta, Suchita Sujoy Das, Sujoy Suman Saha, Suman SWATI VERMA Vinod Rathor, Vinod

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