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Sanjib Bahadur, Sanjib
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Medicine & Pharmacology

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Investigation of oxidative potential of mahasudarshan churna using goat liver as in-vitro experimental model Pandit, Bibhas; Satapathy, Trilochan; Bahadur, Sanjib; Dewangan, Jyoti
Journal of Applied Pharmaceutical Research Vol. 7 No. 2 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (312.452 KB) | DOI: 10.18231/j.joapr.2019.002

Abstract

The American Medical Research Community sounded a heavy metal warning against some herbo-mineral Ayurvedic formulations from Indian System of Medicine sold in United States of America. The products were rejected by Unites States Food and Drug Administration due to the presence of high level of lead, mercury and arsenic as impurities, marked as toxicity inducers. This work has been design to investigate whether the toxicity produced by Mahasudarshan churna is due to the results of lipid peroxidation, as oxidative degradation of phospholipids is one of the causes of drug-induced toxicity. The level of malondialdehyde, reduced glutathione and nitric oxide were estimated in control, drug-treated, drug-antioxidant treated and only antioxidant-treated group at two hours and six hours of incubation time in goat liver homogenates. Ascorbic acid was used to compare the oxidative potentials of Mahasudarshan churna. The level of malondialdehyde was found to be decreased in the drug-treated, drug-antioxidant treated and only antioxidant treated group where as the level of reduced glutathione and nitric oxide increased when compared to control. Above all the Drug-antioxidant treated group showed maximum anti-oxidant properties when compared to other groups. The study was designed to investigate the lipid peroxidation induction capacity of Mahasudarshan churna as consequences of its toxicity and found that lipid peroxidation is not the contributing factor
Formulation, optimization and evaluation of quick dispersible tablets of sumatriptan Baghel, Pragya; Roy, Amit; Chandrakar, Shashikant; Bahadur, Sanjib; Bhairam, Monika
Journal of Applied Pharmaceutical Research Vol. 7 No. 3 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (516.132 KB) | DOI: 10.18231/j.joapr.2019.004

Abstract

The main objective of this study was to prepare quick dispersible tablets of drug sumatriptan succinate, which can rapidly disintegrate in the saliva using three different superdisintegrants that is, sodium starch glycolate, crospovidone, and croscarmallose sodium with taste masking polymer beta-cyclodextrin and aspartame as a sweetener. The taste masking of the drug was done by mixing it with the polymer beta-cyclodextrin using solvent evaporation method and then mixing optimized quantity of aspartame to it. The quick dispersible tablets were prepared by direct compression technique using taste masked drug and other formulation excipients. The effect of various super disintegrants in three different concentrations has been studied. The prepared tablets were evaluated for wetting time, in-vitro disintegration time, strength, and in-vitro dissolution time. As per the results obtained, it was found that the formulation batch no. 4 was found to be the best formulation, as the data’s obtained by it was found to be in the required range of mouth dissolving tablets.
Co-Authors Alisha Banafar, Alisha Amit Roy, Amit Ananta Choudhury, Ananta Chandrakar, Shashikant Dewangan, Jyoti Dhanushram Turkane, Dhanushram Dipesh Sahu, Dipesh Ghanshyam Sahu, Ghanshyam Monika Bhairam, Monika Pandit, Bibhas Pragya Baghel, Pragya Ranabir Chanda, Ranabir Sahu, Uttam Kumar Sujoy Das, Sujoy Suman Saha, Suman Trilochan Satapathy, Trilochan Uttam Sahu, Uttam