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All Journal Jurnal Kesehatan Mesencephalon Heart Science Journal JOURNAL SCIENTIFIC OF MANDALIKA (JSM) Innovative: Journal Of Social Science Research
Wiwit Nurwidyaningtyas, Wiwit
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Humanities Computer Science & IT Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Other

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IPTEK BAGI MASYARAKAT : “Let’s Be Survivor Cardio” UPAYA REGULASI PERILAKU BERESIKO CARDIOVASCULAR DISEASE TAHUN 2014 Nurwidyaningtyas, Wiwit; Kholifah, Siti
Jurnal Kesehatan Mesencephalon Vol 3, No 1 (2017): Jurnal Kesehatan Mesencephalon - April 2017
Publisher : Jurnal Kesehatan Mesencephalon

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (84.886 KB)

Abstract

Abstract : Various risk factors such as smoking, hypertension, chronic elevated blood sugar levels, increased blood fat levels that not controlled and the lack of sporting activity are directly proportional to the increase in the prevalence of cardiovascular disease (CVD). But people generally do not realize that these risk factors closely related to unhealthy lifestyles inherent in public behavior, including the family environment. Lack of family awareness about  risk of CVD patterns become an important point in the risk factor control strategies through the dissemination and application of a pilot project in a targeted area. This program aims to encourage families built to be able to control or reduce behaviors or habits that lead to CVD risk behavior. In Higher Education program funded IbM we try to apply the smart card on the family built that called logbook for monitoring indicators of risk behavior includes, waist circumference, blood pressure, blood glucose monitoring and blood fat, diet and exercise and smoking habits. This program is facilitated by local cadres who previously had trained  on CVD risk factors during cadre training program in Rampal Celaket Public Health Services working area has been done in 2013. Then family discipline built for the implementation of an advanced program "One card for my neighbor" will be evaluated. Evaluation of the results of the program indicate that the socialization of the healthy heart control card has been given to the family target is not directly proportional to the discipline of monitoring indicators of risky behaviors. This results still far from the expectation, considering the risk factors for CVD inherent in the life behavior is still not a priority needs and yet to be felt as actual symptoms that adversed family.Keywords : cardiovascular disease, risk, regulation Abstrak: Berbagai faktor resiko seperti merokok, hipertensi, peningkatan kadar gula darah kronis, peningkatan kadar lemak darah yang tidak terkontrol dan kurangnya aktivitas olah raga berbanding lurus dengan peningkatan prevalensi cardiovascular disease (CVD). Namun masyarakat pada umumnya tidak menyadari bahwa faktor resiko tersebut erat kaitannya dengan pola hidup tidak sehat yang melekat pada perilaku masyarakat termasuk lingkungan keluarga. Kurangnya kesadaran keluarga akan pola kebiasaan beresiko CVD menjadi poin penting dalam penyusunan strategi pengendalian faktor resiko melalui sosialisasi dan aplikasi pilotproject dalam suatu area binaan. Program ini bertujuan mendorong keluarga binaan untuk dapat mengendalikan atau berupaya mengurangi perilaku atau kebiasaan yang mengarah pada perilaku beresiko CVD. Dalam program IbM yang didanai DIKTI ini kami mencoba mengaplikasikan kartu cerdas pada keluarga binaan yang disebut sebagai logbook untuk pemantauan indikator perilaku beresiko meliputi, lingkar perut, tekanan darah, pemantauan gula darah dan lemak darah, pola makan dan olahraga serta kebiasaan merokok. Program ini difasilitasi oleh kader setempat yang sebelumnya telah dierikan pelatihan tentang faktor resiko CVD pada program pelatihan kader wilayah kerja PKM Rampal Celaket yang telah dilakukan pada tahun 2013. Kemudian akan dievaluasi kedisiplinan keluarga binaan untuk pelaksanaan program lanjutan “Satu kartu untuk tetangga-Ku”. Evaluasi hasil program menunjukkan bahwa sosialisasi kartu kendali jantung sehat yang telah diberikan pada keluarga binaan tidak berbanding lurus dengan kedisiplinan pemantauan indikator perilaku beresiko dengan hasil yang masih jauh dari harapan mengingat faktor resiko CVD yang melekat pada perilaku hidup masyarakat masih belum menjadi prioritas kebutuhan dan belum dirasakan adanya gejala aktual yang merugikan keluarga.Kata kunci :cardiovascular disease, resiko, regulasi
Pengaruh Aromaterapi Peppermint & PMR untuk Mengurangi Mual Muntah Pasien Kemoterapi Kanker Payudara Pertiwi, Carita Intan; Arsa, Putu Sintya Arlinda; Rahmawati, Nadhifa; Nurwidyaningtyas, Wiwit
Innovative: Journal Of Social Science Research Vol. 5 No. 1 (2025): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v5i1.17684

Abstract

Kanker adalah suatu istilah untuk penyakit dimana sel-sel abnormal membelah tanpa kontrol dan dapat menyerang jaringan di dekatnya. Pengobatan kanker dengan kemoterapi akan menimbulkan respon fisik dan psikologis. Respon fisik yang dirasakan salah satunya adalah keluhan mual muntah. Aromaterapi Peppermint & PMR (Progressive Muscle Relaxation) adalah kombinasi terapi komplementer yang memiliki efek karminatif dan anti spasmodik yang bekerja di usus halus pada saluran gastrointestinal yang mampu mengurangi mual muntah. Tujuan penelitian ini untuk mengetahui pengaruh pemberian kombinasi Aromaterapi Peppermint & PMR untuk mengurangi keluhan mual muntah pasien kemoterapi kanker payudara. Metode penelitian Quasi – eksperimental tipe Pre-Post Test Nonequivalent Control Group Design. Sampel penelitian ini adalah pasien kanker yang menjalani kemoterapi injeksi sebanyak 36 orang dengan teknik purposive sampling. Instrumen penelitian menggunakan Kuesioner Mual Muntah Rhodes INVR/Rhodes Index for Nausea, Vomiting,and Retching (INVR). Uji analisis statistik didapatkan hasil ada pengaruh yang signifikan pemberian Aromaterapi Peppermint & Progressive Muscle Relaxation (p-value 0,000 < 0,05). Hasil penelitian didapatkan bahwa Aromaterapi Peppermint & Progressive Muscle Relaxation dapat dipakai sebagai metode alternatif dalam mengurangi keluhan mual muntah pasien kemoterapi.
Pengaruh Playdough Terapi Terhadap Penurunan Perilaku Agresif Anak Pra Sekolah Selama Hospitalisasi di Ruang St Theresia Rs Panti Nirmala Malang Nurul Anjarwati; Lembah Andriani; Nurwidyaningtyas, Wiwit; Fitri Dwi Astuti
Journal Scientific of Mandalika (JSM) e-ISSN 2745-5955 | p-ISSN 2809-0543 Vol. 6 No. 6 (2025)
Publisher : Institut Penelitian dan Pengembangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/10.36312/vol6iss5pp1479-1487

Abstract

Preschool- age children accept hospital admission with fear. Several measures have been widely recommended to minimize the impact of hospitalization, but until now the most widely used and believed to be most effective is with play therapy. In preschool, one type of game is skill play, where this type of game uses motor skills. One of the skill play games is playing playdough. This study have the purpose was to determine the Effect of Playdough Therapy on Reducing Aggressive Behavior of Preschool Children During Hospitalization in the St. Theresia Room of Panti Nirmala Hospital Malang. The research design used Pre- Experimental Design with the Pretest-Posttest with Control Group Design, the sampling technique used was purposive sampling as many as 20 respondents on intervention group and control group. Analysis test on the Mann Whitney, the result was a significant difference between the aggresive level score of the control group pre-test and the treatment group (p=0.002< 0.05), the aggressive level score of the control group and the treatment group (p = 0.001< 0.05). Based on the results of the Wilcoxon test, it shows a significant difference in the level of aggressiveness (p = 0.000< 0.05). So, it can be concluded that the administration of playdough therapy in pediatric patients is very necessary to reduce aggressiveness due to hospitalization in children
The role of SIRT1 activator in preventing endothelial dysfunction: A systematic review in vitro studies evaluating senescence markers and cellular senescence-associated outcomes Rahma, Oktivani Adelathifa; Rohman, Mohammad Saifur; Akbar, Naufal Zulfikar; Rohman, Ibrahim Abdur; Nurwidyaningtyas, Wiwit
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.5

Abstract

Background: Endothelial dysfunction, largely driven by endothelial senescence, is a critical factor in the pathogenesis of cardiovascular diseases. SIRT1, a key regulator of vascular homeostasis, has been identified as a potential target for mitigating endothelial senescence. Activators of SIRT1 have shown promise in delaying cellular senescence by modulating senescence markers and inflammatory pathways. However, a comprehensive evaluation of their effectiveness in in vitro models is required. Methods: This systematic review follows PRISMA 2020 guidelines and SYRCLE’s risk of bias assessment. Studies from four databases (PubMed, ScienceDirect, SpringerLink, and Taylor & Francis) were screened based on eligibility criteria, focusing on in vitro studies using Human Umbilical Vein Endothelial Cells (HUVECs) treated with SIRT1 activators. Key outcomes analyzed included senescence-associated β-galactosidase (SA-β-gal), cyclin-dependent kinase inhibitors (CDKIs: p21, p53, and p16), and senescence-associated secretory phenotype (SASP). Results: A total of 20 studies met the inclusion criteria. SIRT1 activators, including dapagliflozin, rhHAPLN1, ginsenoside Rb1, resveratrol, and others, demonstrated significant reductions in SA-β-gal expression, oxidative stress, and inflammatory cytokines (IL-6, IL-1β, and CCL2). Additionally, SIRT1 activation was associated with downregulation of CDKIs and enhanced nitric oxide (NO) bioavailability, contributing to improved endothelial function. Conclusion: SIRT1 activators exhibit potential in delaying endothelial senescence by suppressing senescence markers and inflammatory mediators, thereby preserving endothelial integrity. Future studies should focus on clinical validation to explore their therapeutic applications in endothelial senescence and cardiovascular disease prevention
In silico molecular docking investigation of Morus L. bioactive compounds as potential SIRT1 activators for endothelial anti-aging therapy Rahma, Oktivani Adelathifa; Rohman, Mohammad Saifur; Akbar, Naufal Zulfikar; Rohman, Ibrahim Abdur; Nurwidyaningtyas, Wiwit
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.8

Abstract

Background: The silent progression of vascular aging, characterized by endothelial dysfunction, has been closely linked to a decline in SIRT1 activity. Natural polyphenols have drawn increasing attention as potential modulators of this longevity-associated enzyme, offering therapeutic promise through antioxidant and anti-inflammatory effects. Objective: This study aimed to conduct an in silico analysis of natural SIRT1 activators, compare their interactions with simvastatin, and explore their structure-activity relationships to identify potential candidates for vascular-protective nutraceuticals or therapeutic adjuvants. Methods: Molecular docking was performed using PyRx 8.0 to assess ligand-SIRT1 interactions. Pharmacokinetic properties were evaluated through Lipinski’s Rule of Five and Veber’s Rule using SwissADME, while toxicity predicted with ProTox-II. Ligand-receptor interactions were visualized using LigPlot+. Result: Moracin demonstrated the strongest binding affinity to SIRT1 (–11.3 kcal/mol), followed by resveratrol (–9.6 kcal/mol), chlorogenic acid (–9.5 kcal/mol), and quercetin (–8.9 kcal/mol), all outperforming simvastatin (–8.4 kcal/mol). Moracin, resveratrol, and quercetin satisfied key drug-likeness criteria, while chlorogenic acid showed limitations in permeability. Toxicity profiling positioned resveratrol as the safest compound (GHS class 6), with moracin and quercetin also showing favorable profiles. Simvastatin exhibited broader toxicity risks. Conclusion: In silico and molecular docking results presented evidence for the potential of Morus L. polyphenols, especially moracin and resveratrol, as SIRT1 activators for endothelial anti-aging therapy. However, these findings remain predictive and require further validation through in vitro and in vivo studies to confirm the therapeutic efficacy and safety of these compounds as anti-aging agents.
Co-Authors Akbar, Naufal Zulfikar Anjarwati, Nurul Fitri Dwi Astuti Lembah Andriani Mohammad Saifur Rohman Pertiwi, Carita Intan Putu Sintya Arlinda Arsa Rahma, Oktivani Adelathifa Rahmawati, Nadhifa Rohman, Ibrahim Abdur SITI KHOLIFAH