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All Journal Heart Science Journal Jurnal Abdimas Kartika Wijayakusuma
Rohman, Ibrahim Abdur
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Humanities Education Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences Other

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Pencegahan Stunting dan Disbiosis Mikrobiota Saluran Cerna Melalui Partisipasi Aktif Siswa, Orang Tua dan Guru Sekolah Dasar di Kabupaten Malang Mulyastuti, Yuanita; Rahayu, Siwipeni Irmawanti; Tulle, Andrew William; Ruliatna, Etty Fitria; Sutjipto, Yossy Imelda; Nuriyana, Fatatie; Rohman, Ibrahim Abdur; Dzulfikar, Afuza Ahnaf; Ilhami, Mukhammad Nurvi Farhan; Bekti, Rachmad Sarwo
Jurnal Abdimas Kartika Wijayakusuma Vol 6 No 1 (2025): Jurnal Abdimas Kartika Wijayakusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jakw.v6i1.656

Abstract

Stunting merupakan masalah kesehatan dengan efek jangka panjang berupa risiko penurunan produktivitas pembangunan nasional. Dampak stunting dapat dicegah dengan perbaikan literasi anak, guru dan orang tua saat anak usia sekolah dasar. Disbiosis saluran cerna sebagai salah satu faktor yang berperan pada kejadian stunting dapat dicegah dengan pola makan seimbang serta pola hidup bersih dan sehat. Desain program pengabdian masyarakat ini bersifat partisipatoris dengan melibatkan guru, siswa, dan orang tua terkait literasi tentang stunting. Program dilakukan dalam beberapa tahap meliputi penyusunan agenda bersama, penyuluhan edukasi, pemilihan duta siswa sehat, serta diskusi penyusunan rencana pengembangan program dengan guru. Dari pengabdian masyarakat yang dilakukan, didapatkan perubahan literasi kognitif siswa terhadap perilaku sehat yang berhubungan dengan stunting seperti pola makan seimbang dan pola hidup bersih dan sehat. Sementara diskusi dengan guru memunculkan upaya kerjasama penguatan program UKS (Usaha Kesehatan Sekolah) dengan pola UES (University to Elementary School) sebagai bentuk tindak lanjut untuk melembagakan upaya peningkatan kesehatan siswa secara konstruktif. Penelitian lebih lanjut perlu dilakukan sebagai evaluasi jangka panjang dari pengabdian, terutama pada dampak lanjut dari duta siswa dan penguatan UKS melalui skema UES.
The role of SIRT1 activator in preventing endothelial dysfunction: A systematic review in vitro studies evaluating senescence markers and cellular senescence-associated outcomes Rahma, Oktivani Adelathifa; Rohman, Mohammad Saifur; Akbar, Naufal Zulfikar; Rohman, Ibrahim Abdur; Nurwidyaningtyas, Wiwit
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.5

Abstract

Background: Endothelial dysfunction, largely driven by endothelial senescence, is a critical factor in the pathogenesis of cardiovascular diseases. SIRT1, a key regulator of vascular homeostasis, has been identified as a potential target for mitigating endothelial senescence. Activators of SIRT1 have shown promise in delaying cellular senescence by modulating senescence markers and inflammatory pathways. However, a comprehensive evaluation of their effectiveness in in vitro models is required. Methods: This systematic review follows PRISMA 2020 guidelines and SYRCLE’s risk of bias assessment. Studies from four databases (PubMed, ScienceDirect, SpringerLink, and Taylor & Francis) were screened based on eligibility criteria, focusing on in vitro studies using Human Umbilical Vein Endothelial Cells (HUVECs) treated with SIRT1 activators. Key outcomes analyzed included senescence-associated β-galactosidase (SA-β-gal), cyclin-dependent kinase inhibitors (CDKIs: p21, p53, and p16), and senescence-associated secretory phenotype (SASP). Results: A total of 20 studies met the inclusion criteria. SIRT1 activators, including dapagliflozin, rhHAPLN1, ginsenoside Rb1, resveratrol, and others, demonstrated significant reductions in SA-β-gal expression, oxidative stress, and inflammatory cytokines (IL-6, IL-1β, and CCL2). Additionally, SIRT1 activation was associated with downregulation of CDKIs and enhanced nitric oxide (NO) bioavailability, contributing to improved endothelial function. Conclusion: SIRT1 activators exhibit potential in delaying endothelial senescence by suppressing senescence markers and inflammatory mediators, thereby preserving endothelial integrity. Future studies should focus on clinical validation to explore their therapeutic applications in endothelial senescence and cardiovascular disease prevention
In silico molecular docking investigation of Morus L. bioactive compounds as potential SIRT1 activators for endothelial anti-aging therapy Rahma, Oktivani Adelathifa; Rohman, Mohammad Saifur; Akbar, Naufal Zulfikar; Rohman, Ibrahim Abdur; Nurwidyaningtyas, Wiwit
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.8

Abstract

Background: The silent progression of vascular aging, characterized by endothelial dysfunction, has been closely linked to a decline in SIRT1 activity. Natural polyphenols have drawn increasing attention as potential modulators of this longevity-associated enzyme, offering therapeutic promise through antioxidant and anti-inflammatory effects. Objective: This study aimed to conduct an in silico analysis of natural SIRT1 activators, compare their interactions with simvastatin, and explore their structure-activity relationships to identify potential candidates for vascular-protective nutraceuticals or therapeutic adjuvants. Methods: Molecular docking was performed using PyRx 8.0 to assess ligand-SIRT1 interactions. Pharmacokinetic properties were evaluated through Lipinski’s Rule of Five and Veber’s Rule using SwissADME, while toxicity predicted with ProTox-II. Ligand-receptor interactions were visualized using LigPlot+. Result: Moracin demonstrated the strongest binding affinity to SIRT1 (–11.3 kcal/mol), followed by resveratrol (–9.6 kcal/mol), chlorogenic acid (–9.5 kcal/mol), and quercetin (–8.9 kcal/mol), all outperforming simvastatin (–8.4 kcal/mol). Moracin, resveratrol, and quercetin satisfied key drug-likeness criteria, while chlorogenic acid showed limitations in permeability. Toxicity profiling positioned resveratrol as the safest compound (GHS class 6), with moracin and quercetin also showing favorable profiles. Simvastatin exhibited broader toxicity risks. Conclusion: In silico and molecular docking results presented evidence for the potential of Morus L. polyphenols, especially moracin and resveratrol, as SIRT1 activators for endothelial anti-aging therapy. However, these findings remain predictive and require further validation through in vitro and in vivo studies to confirm the therapeutic efficacy and safety of these compounds as anti-aging agents.
Co-Authors Akbar, Naufal Zulfikar Dzulfikar, Afuza Ahnaf Ilhami, Mukhammad Nurvi Farhan Mohammad Saifur Rohman Nuriyana, Fatatie Rachmad Sarwo Bekti Rahayu, Siwipeni Irmawanti Rahma, Oktivani Adelathifa Ruliatna, Etty Fitria Sutjipto, Yossy Imelda Tulle, Andrew William Wiwit Nurwidyaningtyas, Wiwit Yuanita Mulyastuti