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All Journal Medical Sains : Jurnal Ilmiah Kefarmasian JURNAL FARMASI DAN KESEHATAN INDONESIA Medical Sains : Jurnal Ilmiah Kefarmasian
Novalisa Nindhi Soraya
Universitas Duta Bangsa Surakarta
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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NANOEMULSION-BASED MOUTHWASH OF ETHYL ACETATE FRACTION OF SERAI WANGI STALK: FORMULATION, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY TEST Desy Ayu Irma Permatasari; Weri Veranita; Novalisa Nindhi Soraya; Eva Kholifah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.908

Abstract

Serai wangi or citronella (Cymbopogon nardus L.) has long been used in Indonesia as a component of traditional medicine. A recent study aimed to determine the antibacterial activity of the most active fraction of Citronella stalk extract and to formulate it  into a nanoemulsion mouthwash. Fractionation of the ethanolic extract was carried out using liquid-liquid extraction, and it was found that the ethyl acetate fraction (EAF) was the most active. This fraction was then varied at concentrations of 25%, 12.5%, 6.25%, 3.125%, 1.5625%, and 0.78125% for the antibacterial activity test using the disc diffusion test method. To determine the potency of microbial activity, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were evaluated. Subsequently, the ethyl acetate fraction was formulated into a nanoemulsion and characterized by measuring the transmittance percentage, droplet size, and polydispersity index (pdI) using a particle size analyzer. The results showed that the ethyl acetate fraction at a concentration of 25% obtained an inhibition zone diameter of 10.67 mm. MIC and MBC values ??were obtained at a fraction concentration of 6.25%. In addition, characterization of formulae exhibited particle size and pdI as follow 101.6 nm and 0.681 (Formula I); 84.1 nm and 0.609 (Formula II); 108.3 nm and 0.527 (Formula III).  Keywords:  Citronella stalk; fractionation; Streptococcus mutans; nano-emulsion; mouth wash
TINGKAT KEPUASAN PASIEN TERHADAP PELAYANAN KOMUNIKASI, INFORMASI, DAN EDUKASI (KIE) OBAT OLEH TENAGA KEFARMASIAN DI APOTEK NOGOSARI FARMA Novalisa Nindhi Soraya; Era Wandira; Nadia Aisy Andika; Nasya Bella Salsabilla; Aris Prio Agus Santoso; Tatiana Siska Wardani
JURNAL FARMASI DAN KESEHATAN INDONESIA Vol. 2 No. 1 (2022): Jurnal Farmasi dan Kesehatan Indonesia
Publisher : Universitas Kristen Immanuel

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61179/jfki.v2i1.270

Abstract

Telah dilakukan penelitian tentang tingkat kepuasan pasien terhadap pelayanan komunikasi, informasi, dan edukasi (KIE) obat oleh tenaga kefarmasian di apotek nogosari farma.Penelitian dilakukan dengan metode deskriptif dengan model penelitian observasi. Data dikumpulkan dari 50 responden melalui kuesioner pada bulan November 2021. Metode pengambilan sampel yang digunakan yaitu random sampling. Hasil penelitian menunjukkan bahwa dari 50 responden masih ada kekurangan dari tenaga teknis kefarmasian apotek dalam melakukan pelayanan KIE sesuai standart. Adapun hasil rata- rata presentase kepuasan pasien yakni 82% puas dan 12% pasien tidak puas.
NANOEMULSION-BASED MOUTHWASH OF ETHYL ACETATE FRACTION OF SERAI WANGI STALK: FORMULATION, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY TEST Desy Ayu Irma Permatasari; Weri Veranita; Novalisa Nindhi Soraya; Eva Kholifah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.908

Abstract

Serai wangi or citronella (Cymbopogon nardus L.) has long been used in Indonesia as a component of traditional medicine. A recent study aimed to determine the antibacterial activity of the most active fraction of Citronella stalk extract and to formulate it  into a nanoemulsion mouthwash. Fractionation of the ethanolic extract was carried out using liquid-liquid extraction, and it was found that the ethyl acetate fraction (EAF) was the most active. This fraction was then varied at concentrations of 25%, 12.5%, 6.25%, 3.125%, 1.5625%, and 0.78125% for the antibacterial activity test using the disc diffusion test method. To determine the potency of microbial activity, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were evaluated. Subsequently, the ethyl acetate fraction was formulated into a nanoemulsion and characterized by measuring the transmittance percentage, droplet size, and polydispersity index (pdI) using a particle size analyzer. The results showed that the ethyl acetate fraction at a concentration of 25% obtained an inhibition zone diameter of 10.67 mm. MIC and MBC values ??were obtained at a fraction concentration of 6.25%. In addition, characterization of formulae exhibited particle size and pdI as follow 101.6 nm and 0.681 (Formula I); 84.1 nm and 0.609 (Formula II); 108.3 nm and 0.527 (Formula III).  Keywords:  Citronella stalk; fractionation; Streptococcus mutans; nano-emulsion; mouth wash
Co-Authors Aris Prio Agus Santoso Desy Ayu Irma Permatasari Era Wandira Eva Kholifah Nadia Aisy Andika Nasya Bella Salsabilla Tatiana Siska Wardani Veranita, Weri