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Kompartemen Sindrom Ekstremitas Bawah : Diagnosis, Anatomi dan Tatalaksana Fuad Iqbal Elka Putra; Hanifah Hanum
Medula Vol 13 No 7 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i7.839

Abstract

Abstract Acute compartment syndrome (ACS) is an orthopaedic emergency that can threaten life and limb. A comprehensive understanding of anatomy, along with proper diagnosis and treatment, plays a crucial role in preventing lower limb ischemia. We conducted an updated review of the literature using digital databases such as PubMed, Springer Link, and Science Direct. A clinical diagnosis of compartment syndrome must be followed by surgical decompression. Clinical signs of ACS include the 6 P’s: pain, poikilothermia, pallor, paresthesia, pulselessness, and paralysis. This literature review revealed that some studies showed fasciotomy is an emergency surgical procedure performed to decompress a compartment. The most common and validated method to measure limb intracompartment pressure (ICP) is by using the handheld Stryker Intra-Compartmental Pressure (STIC) Monitor System. Lower leg compartment divided into anterior, lateral, superficial posterior and deep posterior compartment, inside of compartment there are muscle, nerve, artery and vein. After diagnosis compartment syndrome we should continue to surgical decompression by fasciotomy in two methode medial incision (deep and superficial posterior compartment) and lateral incision (anterior and lateral compartments). As a conclusion early recognition and diagnosis of conditions of compartment syndrome are essential in preventing lower limb ischemia. Keywords: acute compartment syndrome, intracompartmental pressure, lower extremity
Pengaruh Maraknya Judi Online Terhadap Pengelolaan Keuangan di Kalangan Mahasiswa: Studi Kasus: Mahasiswa Universitas Negeri Medan Hapni Laila Siregar; Diana Puspita Ayu; Hanifah Hanum; May Sartika; Silvia Annur Hasibuan
Jurnal Riset Rumpun Ilmu Ekonomi Vol. 4 No. 2 (2025): Oktober: Jurnal Riset Rumpun Ilmu Ekonomi
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrie.v4i2.5098

Abstract

The purpose of this research is to examine how Medan State University students' financial management is affected by the widespread practice of online gambling.  The increasingly accessible online gambling phenomena has led to a number of issues, particularly with regard to the personal financial situation of students.  60 students were chosen as a sample for this study, which used a quantitative approach with a survey methodology.  With the use of SPSS 25 software and basic linear regression, data analysis was completed. The purpose of this research is to examine how Medan State University students' financial management is affected by the widespread practice of online gambling.  The increasingly accessible online gambling phenomena has led to a number of issues, particularly with regard to the personal financial situation of students.  60 students were chosen as a sample for this study, which used a quantitative approach with a survey methodology.  With the use of SPSS 25 software and basic linear regression, data analysis was completed.
Potensi Pemanfaatan Kandungan Tocotrienol-Rich Fraction (TRF) dalam Crude Palm Oil (CPO) berbasis Nanopartikel Poly (Ethylene Glycol)-b-Poly (D,L-Lactic Acid-co-Glycolic Acid)-b-Poly (Ethylene Glycol) (PEG-b-PLGA-b-PEG) sebagai Kemoterapi pada Kanker Serviks Fadel Muhammad Ikrom; Yulia Cahya Khasanah; Hanifah Hanum
Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Vol. 6 No. 2 (2019): Jurnal Kesehatan dan Agromedicine
Publisher : Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia merupakan peringkat dua dalam jumlah kasus kanker serviks di dunia. Terjadi 21 ribu kasus kanker serviks dan lebih dari sembilan ribu wanita di Indonesia meninggal karena kanker serviks. Saat ini, kemoterapi yang sering digunakan dalam penanganan kanker serviks adalah terapi kombinasi obat golongan sitotoksik cisplatin dan fluorouracil. Akan tetapi, golongan obat tersebut mempunyai efek toksisitas yang tinggi. Berdasarkan fakta tersebut, perlu dilakukan suatu inovasi kemoterapi yang memiliki efek toksisitas yang lebih rendah yaitu dengan pemanfaatan bahan alam berupa Tocotrienol-Rich Fraction (TRF) yang berasal dari Crude Palm Oil (CPO) sebagai kemoterapi pada kanker serviks TRF bekerja dengan cara mempengaruhi beberapa signaling pathways pada sel kanker, dan memperantarai beberapa mekanisme sel termasuk reduksi kerusakan DNA, aktivasi apoptosis, induksi penghentian siklus sel, stabilisasi proteasome, dan aktivasi telomerase. TRF memiliki kelemahan yaitu bioavailabilitas yang rendah disebabkan rendahnya afinitasnya terhadap protein plasma pembawa yang menyebabkan banyaknya kadar obat bebas di sirkulasi. Untuk itu diperlukan suatu drug delivery carrier yang dapat meningkatkan bioavailibilitas dan sensitivitas TRF. Drug delivery carrier yang telah diketahui memiliki keuntunganialah penggunaan kombinasi nanopartikel tri blok copolymer PEG-b-PLGA-b-PEG. Aplikasi nanopartikel tri blok copolymer PEG-b-PLGA-b-PEG berhasil meningkatkan bioavailibilitas dan waktu paruh terhadap modalitas yang terkandung didalamnya.Kata kunci: Crude Palm Oil, Kanker Serviks, PEG-b-PLGA-b-PEG, Tocotrienol-Rich Fraction