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All Journal Jurnal Kedokteran Diponegoro Majalah Kedokteran Andalas ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Keluwih: Jurnal Kesehatan dan Kedokteran International Islamic Medical Journal Jurnal Ilmu Medis Indonesia Indonesian Andrology and Biomedical Journal Jurnal Studi Ilmu Sosial dan Politik Indonesian Journal of Dentistry Current Biomedicine Bisai: Jurnal Bahasa, Sastra dan Pengajarannya Kajian Psikologi dan Kesehatan Mental
Fiki Muhammad Ridho
Faculty Of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Epidemiological Analysis and Management of Oral and Craniomaxillofacial Trauma in Indonesia: A Systematic Review Fiki Muhammad Ridho; Alfi Syahri; Pulung Dwisari
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Supplementary April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1667-1687.2024

Abstract

Objective: This systematic review aims to analyze and review the epidemiological characteristics and management of oral and craniomaxillofacial trauma in patients in Indonesia. Methods: Using PRISMA guidelines, a systematic review of articles published in Scopus, PubMed, ScienceDirect, Google Scholar, and Garuda up to March 2024 was conducted. In selecting studies, inclusion and exclusion criteria were applied. Results: This study included 2,928 cases of oral and craniomaxillofacial trauma obtained from a total of 44 studies consisting of 25 case reports, 11 retrospective studies, 7 cross-sectional studies, and 1 case series. Summary results from pooled data, this study highlights that male patients predominate in all cases with a total of 80.70% and the male/female ratio is 4.2:1. Oral and craniomaxillofacial trauma occurred mostly in the 21-30 year age group (25.51%), followed by 11-20 year olds (24.15%) and 31-40 year olds (16.73%). Based on etiology, most cases occurred due to traffic accidents (87.88%). In the management of trauma cases, open reduction and internal fixation (ORIF) is the most frequently performed with a total of 66.71% of all cases. Conclusion: Oral and craniomaxillofacial trauma in Indonesia is dominated by male patients and in the productive age group with mandibular fractures being the highest cases.
In vitro and in vivo effects of curcumin on oral cancer: a systematic review Ridho, Fiki Muhammad; Syachputra, Andika Julyanto; Fahrudin, Panggih; Nurhuda, Andang; Nurliana, Nurliana; Latuamury, Nadhia S
Current Biomedicine Vol. 2 No. 2 (2024): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.2.2.101-115

Abstract

Background: Current therapy for oral cancer (OC) patients, including surgery, radiotherapy, and chemotherapy, still have many shortcomings. Therefore, the discovery of natural products to prevent and treat cancer is receiving increasing attention, one of which is curcumin. Curcumin (diferuloylmethane) is a polyphenolic compound found in turmeric (Curcuma longa) and has been widely used as a herbal medicine because of its effects on health, one of which is as an anticancer agent. Objective: This study aimed to systematically and comprehensively review and summarize the anticancer effects and mechanisms of action involved of curcumin on OC cells. Methods: A systematic review methodology was employed adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines to review and summarize previous studies published in databases, including PubMed, ScienceDirect, and Google Scholar. The final results included 14 articles, both in vitro and in vivo studies. Results: Based on several preclinical studies regarding the effects of curcumin on OC cells, we highlight that curcumin has a strong potential in inhibiting OC cells through exerted effects such as immunomodulatory and anti-inflammatory effects, through inhibition of cell proliferation, invasion and migration, and angiogenesis, as well as through the induction of apoptosis and autophagy. Conclusion: The systematic review presented in this paper concludes that curcumin possesses the potential to inhibit the development of OC cells through several mechanisms of action related to immunomodulatory effects, anti-inflammatory effects, cell proliferation, invasion and migration, angiogenesis, apoptosis, and autophagy.
Mechanism of Apoptosis Induction in Oral Cancer Cells by Uncaria-derived Flavonoids Ridho, Fiki Muhammad; Iqbal, Mohammad; Agustina, Arista Widya; Syachputra, Andika Julyanto
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.42944

Abstract

Introduction: Oral cancer is cancer that occurs in the oral cavity and oropharynx, ranking 16th as the most common cancer found with a number of new cases of 377,713 and a number of deaths of 177,757 cases in 2020. Several types of flavonoids contained in the genus Uncaria were found to have anticancer bioactivity, one of which is inducing apoptosis in oral cancer cells. Aim: This study aims to review the potential and mechanisms involved of flavonoids in inducing apoptosis in oral cancer cells. The literature review method was used in this study by conducting a systematic literature search on PubMed, ScienceDirect, and Google Scholar until October 2023. Results: A total of 13 studies were included in this study and our findings conclude that flavonoids, especially quercetin, kaempferol, rutin, umbelliferon, and epigallocatechin gallate (EGCG), have the potential to be used as anticancer agents, one of which has the ability to induce apoptosis, both through extrinsic and intrinsic pathway, in several oral cancer cell lines, including SCC-4, SCC-9, SCC-25, SAS, KB/VCR, Tca-8113, YD10B, YD38, MC-3, KB, and HSC-3, through the mechanism of inhibiting anti-apoptotic expression, activating pro-apoptotic protein expression, generating ROS, and regulating PI3K/AKT, MAPK, and JAK/STAT signaling pathways. Conclusion: We conclude that Uncaria-derived flavonoids hav the potential to induce apoptosis, both extrinsic and intrinsic, in oral cancer cells.
Correlation between Salivary Cortisol Levels in Patients with Psychological Stress and Incidence of Recurrent Aphthous Stomatitis: A Scoping Review Ridho, Fiki Muhammad; Maulidina, Aufa Alma’as Nabila; Allifiah, Bella Pardian Nur
Indonesian Journal of Dentistry Vol 4, No 1 (2024): February 2024
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/ijd.v4i1.14026

Abstract

Background: The etiology of recurrent aphthous stomatitis (RAS) is still unclear, but psychological stress is thought to contribute to the occurrence of RAS. One of the biomarkers for evaluating psychological stress levels is through measuring salivary cortisol levels. This scoping review aims to review and evaluate the correlation between salivary cortisol levels in individuals with psychological stress and an increased incidence of RAS.Methods: A scoping review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines through databases on PubMed, ScienceDirect, Scopus, ProQuest, and Google Scholar until November 2023. All included studies discussed salivary cortisol levels in RAS patients and controls.Results: Eleven of the twelve studies showed an increase in salivary cortisol levels in RAS patients compared with the control group, with eight of them having a statistically significant increase. In addition, eight studies evaluated the level of psychological stress in respondents, seven of which concluded that there was an increase in stress levels in RAS patients with five of them showing a statistically significant increase.Conclusion: In conclusion, the present study concludes that there is a correlation between increased salivary cortisol levels in individuals with psychological stress and an increased incidence of RAS.
Effectiveness of Classical Music Therapy on Decreasing the Level of Auditory Hallucinations in Schizophrenia Patients: A Literature Review Ridho, Fiki Muhammad
Jurnal Psikiatri Surabaya Vol. 12 No. 2 (2023): November
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jps.v12i2.42373

Abstract

Introduction: Hallucinations are one of the symptoms most often experienced by schizophrenia patients. Auditory hallucinations affect about 70% of schizophrenia patients who experience hallucinations. Classical music therapy is one of the non-pharmacological interventions that can be done. Music can be used as a non-pharmacological therapy option because it can improve, restore and maintain physical, mental, emotional, social and spiritual health. Objective: This study aims to further discuss the effectiveness of classical music therapy in reducing the level of auditory hallucinations in schizophrenia patients. Methods: This study uses the literature review method by searching research data on Google Scholar database. Result: Based on the result of the data search, 8 journals were studied in this study. Discussion: The result found in 8 journals stated that classical music therapy as a non-pharmacological therapy can reduce the intensity of auditory hallucinations in schizophrenia patients. Classical music can evoke changes at the level of important neuromodulators such as dopamine, endorphins, endogenous cannabinoids and nitric oxide. So that the administration of classical music theraoy can eliminate the neurotransmitters of depression, stress, anxiety, and can suppress the symptoms of hallucinations including auditory hallucinations. Conclusion: This study concluded that classical music therapy is effective in reducing the level of auditory hallucinations in schizophrenia patients. Keyword: Classical music therapy, Hallucinations, Schizophrenia
Exploring the Association between Periodontitis and Erectile Dysfunction: A Systematic Review Ridho, Fiki Muhammad; Agustina, Arista Widya; Hidayati, Novi Nurul; Pratama, M. Ilham; Laksono, Eko Puji
Indonesian Andrology and Biomedical Journal Vol. 5 No. 1 (2024): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v5i1.56744

Abstract

Background: Periodontitis (PD) remains a global public health problem. Evidence revealed that PD contributes to the development of systemic diseases, including effects on men's sexual health such as erectile dysfunction (ED). Objective: To review and explore the association between PD and ED. Methods: Following PRISMA guidelines, a systematic review of studies published in Scopus, PubMed, ScienceDirect, and Google Scholar was conducted. A comprehensive literature search until February 2024 by combining several keywords and applying eligibility criteria was performed. JBI critical appraisal checklist was employed for quality assessment. Results: A total of 15 studies involving 216,753 subjects were included. Of the 15 studies, 13 of them demonstrated a significant association between PD and ED, the other two did not. Only one study included examination of hormonal and biochemical levels. Also, one study revealed that periodontal treatment was significantly associated with improving ED. Summary: According to the findings, a significant association between PD and ED is evident. It is believed that the inflammatory processes associated with PD contributes to the emergence of ED, yet the exact underlying mechanism remains unclear. The scarcity of research and the complexity of the association between PD and ED suggest that future rigorous studies should be conducted. Additionally, dentists and general practitioners must be aware of the interconnection between these diseases, enabling them to provide comprehensive education to patients, particularly concerning the prevention and management of periodontal disease.
Periodontitis as a Risk Factor of Preeclampsia in Pregnancy: A Scoping Review Ridho, Fiki Muhammad; Algifnita, Avina Oktaviani; Pramaztri, Naurah Nabilah; Laksono, Eko Puji; Allifiah, Bella Pardian Nur; Ahmad, Mahesa
Jurnal Medis Islam Internasional Vol 5 No 2 (2024)
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v5i2.5316

Abstract

Introduction: Preeclampsia (PE) is a pregnancy complication characterized by hypertension and proteinuria after 20 weeks of gestation. Although the causes of PE are still unclear, there are factors that play an important role in increasing the incidence of PE, namely periodontitis which has an impact on the systemic spread of pathogens and inflammatory mediators, causing adverse pregnancy outcomes. This scoping review aims to evaluate, identify and provide a deeper understanding of the relationship and possible mechanisms between periodontitis and increased PE in pregnant women. A literature search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted in PubMed, ScienceDirect, Scopus, and Google Scholar until July 2023. In the end, 14 articles were included for review. Results: All of the included studies stated that periodontitis mostly affects pregnant women with PE, and periodontitis is believed to play a role in increasing the risk of PE through the mechanism of bacteremia due to periodontal pathogens translocating from the oral cavity to the placenta and through cytokines and inflammatory mediators produced by inflamed periodontal tissue, resulting in disruption of the placenta, further increasing the risk of PE in pregnant women. Conclusions: In conclusion, there is a significant increase in the incidence of PE in pregnant women who experience periodontitis. Future research to review the mechanisms by which periodontitis increases the risk of PE and to examine whether periodontitis treatment before and during pregnancy can prevent PE may be warranted.
Mechanism of Alkaloids and Flavonoids in Bajakah (Uncaria nervosa Elmer) as Antidiabetic Agents Ridho, Fiki Muhammad
Jurnal Ilmu Medis Indonesia Vol. 3 No. 1 (2023): September
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/jimi.v3i1.2296

Abstract

Purpose: Diabetes mellitus is a metabolic disease characterized by hyperglycemic resulting from defects of insulin secretion, insulin action, or both. One of the alternative treatments is bajakah which has antidiabetic activity. This study aims to further discuss the potential and mechanism of alkaloids and flavonoids in bajakah as antidiabetic agents. Method: This study used the literature review method by searching research data on database and 5 articles included for the review. Results: Alkaloids have antidiabetic activity through inhibition of AR, PTP1B, activating AMPK, inhibiting DDP-4 and AGEs, increasing glucose absorption, regenerating pancreatic beta cells, inhibiting and inducing GLUT-4, GSK-3, SREB-1, ACC, PPAR, and glucokinase mechanisms. Meanwhile, flavonoids have activity in pancreatic  beta cell degradation, increasing insulin secretion and sensitivity, glucose homeostasis, glucose absorption through GLUT-2, inhibiting phosphodiesterase, inhibiting alpha glucosidase and  alpha amylase enzymes, inhibiting apoptosis of pancreatic  beta cells, encouraging proliferation, and lowering blood glucose. Limitation: The limitation in this study is that it only used the literature review method which has weaknesses in the data studied. Researcher suggests that more rigorous methods be used in further studies to explore the effectiveness of bajakah in lowering blood glucose level and the need for a toxicity test of bajakah to determine therapeutic doses and lethal doses for the treatment of diabetes mellitus. Contribution: The findings of this study are expected to be a reference in scientific development in the diabetes mellitus treatment using herbal plants. In addition, it is expected that it can increase further knowledge about the mechanism of bajakah as antidiabetic agents.
The Effect of Snail Mucus (Achatina fulica) on Wound Healing after Tooth Extraction: A Literature Review Ridho, Fiki Muhammad; Pamungkas, Adhe Retnantya; Faisal, Ahmad
Jurnal Ilmu Medis Indonesia Vol. 3 No. 1 (2023): September
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/jimi.v3i1.2320

Abstract

Purpose: Tooth extraction is a frequently performed procedure within the field of dentistry, which results in a wound. The wound healing process can be enhanced by chemical and traditional medicines, one of which is snail mucus, which contains active compounds that play an important role in wound healing process. This study aims to further discuss regarding the effect of snail mucus on wound healing process after tooth extraction. Methodology/approach: This literature review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines through PubMed, ProQuest, and Google Scholar database. Results/findings: Snail mucus contains active compounds, such as protein, glycosaminoglycans, metal elements, allantoin, sulfates, calcium, mytimacin-AF, collagen, elastin, glycolic acid, hyaluronic acid, glutathione and vitamins which have effectiveness in enhancing the wound healing process with different mechanisms for each compound, both hemostasis, inflammation, proliferation, and remodeling processes. Limitation: The limitation of this literature review is the lack of high-quality research. Furthermore, the lack of information on the specific doses of snail mucus used and the duration of treatment are critical difficulties that should be addressed in future research to allow for more comprehensive meta-analysis. Additionally, it is required to conduct testing and comparative analysis of the composition of snail mucus across other species in order to ascertain the efficacy of snail mucus content in species other than Achatina fulica. Contribution: The results of this literature review are expected to be a reference in scientific development of wound treatment using traditional medicine, particularly snail mucus. Additionally, it is expected to increase the understanding regarding the effect of snail mucus on wound healing after tooth extraction.
Occupational Asbestos-containing Materials Exposure and Risk of Asbestosis among Construction Workers Ridho, Fiki Muhammad; Ghani, Hafid Nur; Laksono, Eko Puji; Faisal, Ahmad; Nurrahman, Hafidz Arafath
Jurnal Ilmu Medis Indonesia Vol. 3 No. 2 (2024): Maret
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/jimi.v3i2.2986

Abstract

Purpose: Asbestos-containing materials are often found at construction sites, and long-term exposure to accumulated asbestos can increase the risk of asbestos-related diseases, including asbestosis. The present study aimed to further describe the exposure to asbestos in construction workers and the risk of asbestosis, as well as the management and prevention of asbestos exposure. Methodology: The narrative review method was used to conduct this study with a comprehensive literature search of the following databases: PubMed, Scopus, ScienceDirect, and Google Scholar. Results: According to the review, we finally found that many materials in the construction sector contain asbestos and have the potential to spread asbestos fibers into the air and can be inhaled by workers. Cumulative asbestos exposure that occurs in high doses over a long period of time will cause an increases the risk of asbestos-related diseases, including asbestosis. Apart from asbestos exposure, several other factors, such as genetics, smoking, sex, age, and physiology, are closely related to the occurrence and development of asbestosis. The construction sector has the highest exposure to asbestos compared to other sectors or industries and has a high number of asbestosis cases. Thus, it is necessary to provide precautions for workers, such as the use of adequate personal protective equipment of international standards, the presence of health inspectors, and routine checks on workers' health, as well as management of materials or construction waste containing asbestos. Limitations: This study is limited to describing general exposure to asbestos-containing materials and the increased risk of asbestosis in construction workers. Future research regarding further analysis of causal factors, management, and prevention of asbestos exposure, as well as case reports and mapping of asbestosis cases, especially in Indonesia, where related research is still limited, may be warranted. Contribution: This review can be used as a basic reference for conducting further research regarding asbestos exposure to workers and the prevention and management of asbestos-containing materials at construction sites.
Co-Authors Agustina, Arista Widya Ahmad Faisal Ahmad, Mahesa Alfi Syahri Algifnita, Avina Oktaviani Allifiah, Bella Pardian Nur Aruan, Iren Angelia Daniel Happy Putra Dwisari, Pulung Fahrudin, Panggih Ghani, Hafid Nur Hanafi Hanafi Hidayati, Novi Nurul Laksono, Eko Puji Latuamury, Nadhia S Leal, Rafael Sena Saraiva Maulidina, Aufa Alma’as Nabila Moh. Fauzan Nurhuda, Andang NURLIANA NURLIANA Nurrahman, Hafidz Arafath Pamungkas, Adhe Retnantya Pramaztri, Naurah Nabilah Pratama, M. Ilham Pulung Dwisari Syachputra, Andika Julyanto Syahri, Alfi Ulfah, Kamailiya