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All Journal Jurnal Bios Logos Journal of Pharmaceutical and Sciences.
Firman Rezaldi
Program Studi D3 Farmasi, Universitas Mangku Wiyata, Cilegon, Banten, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Fermentasi kombucha bunga telang (Clitoria ternatea L) sebagai produk bioteknologi sederhana dalam memberikan reaksi farmakodinamik mencit (Mus musculus L) yang terpapar asap rokok dan morfometri ovarium Dwiyarina Margarisa; Firman Rezaldi; Isti Dwi Pruschia; Muhammad Andry; M. Fariz Fadillah; Mutia Muhardiyanti; Hendra Jaya; Leni Halimatusyadiah; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.254

Abstract

One of the fertility indicators in women is the optimal functioning of the ovaries. Exposure to cigarette smoke affects the decline in ovarian function in quality and quantity. The main components contained in cigarette smoke include tar, nicotine, carbon monoxide, inorganic gases, heavy metals, nitrosamines, carbonyls, formaldehyde, and polynuclear aromatic hydrocarbons. The main components contained in cigarette smoke positively influence female reproductive hormone levels and even reduce fertility. One of the efforts to prevent free radicals from cigarette smoke and have the potential as a natural antioxidant is consuming butterfly pea flower kombucha. The butterfly pea flower kombucha from previous studies contains phytochemicals that can inhibit free radicals. This study aimed to study the effect of butterfly pea flower kombucha on the ovary morphometry of female mice exposed to cigarette smoke. The design of this study was Completely Randomized Design (CRD). The test animals used were female mice aged 10 to 12 weeks weighing 20 to 20 g in a total of 24 mice. The butterfly pea flower kombucha given was ten mL/L, 20 mL/L, 30 mL/L, and 40 mL/L. Cigarette smoke exposure to mice was carried out on days 1-20 as much as one stick and treated with butterfly pea flower kombucha on days 21-40. Mating of female mice was carried out on the 40th day. Observations of ovarian morphometry such as length, width, weight, and number of corpus luteum were carried out on the 18th day of gestation. ANOVA and DMRT with a confidence level of 1% is the data analysis performed. The conclusion of this study was that butterfly pea flower kombucha had a good effect on improving fertility levels, which could be observed with test parameters such as length, width, weight, and number of corpus luteum and administration of kombucha with a concentration of 40 mL/L was the best treatment.
Bioteknologi Kombucha Bunga Telang Sebagai Formulasi dan Sediaan Spray dalam Menghambat Pertumbuhan Fungi Fusarium solani Penyebab Penyakit Tanaman Komoditas Hortikultura Firman Rezaldi; Rusmana Rusmana; Susiyanti Susiyanti; Maharani Maharani; Ratu Amalia Hayani; Fahmie Firmansyah; Syariful Mubarok
JURNAL BIOS LOGOS Vol. 13 No. 3 (2023): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v13i3.52017

Abstract

Based on the results of previous research, butterfly pea flower kombucha has been proven that apart from being able to be used as a probiotic drink to enhance the immune system, it can be used as an active ingredient in medicines and cosmetics, a raw material for organic liquid fertilizer, and also in formulations and spray preparations designed to inhibit the growth of pathogenic fungi that cause wilt. concave, and brownish on the stems of horticultural commodity plants. This research aims to make a fermented solution of butterfly pea flower kombucha as a formulation and spray preparation designed as an antifungal for Fusarium solani. The Fusarium solani antifungal test of each formulation and the telang flower kombucha spray preparation was carried out using disc diffusion. One-way ANOVA and post hoc analysis are the statistical analyzes used in this research. Based on the one-way ANOVA test with a p value of <0.05 each, followed by post hoc analysis, it was proven that butterfly pea flower kombucha at a sugar concentration of 40% was significantly different as an antifungal for Fusarium solani compared to 20% and 30%. The conclusion in this study is that a sugar concentration of 40% in this study is the best treatment as an antifungal for Fusarium solani, so that apart from being used as a probiotic drink, butterfly pea flower kombucha in this study has the potential to be used as an antifungal for Fusarium solani.
Co-Authors Dwiyarina Margarisa Fahmie Firmansyah Hendra Jaya Isti Dwi Pruschia Leni Halimatusyadiah M. Fariz Fadillah Maharani Maharani Muhammad Amin Nasution Muhammad Andry Mutia Muhardiyanti Ratu Amalia Hayani Rusmana Rusmana Susiyanti Susiyanti Syariful Mubarok