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Marwa Zileikhadira Manzalina
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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PNEUMONITIS HIPERSENSITIF SEBUAH TINJAUAN PUSTAKA Marwa Zileikhadira Manzalina
Jurnal Medika Hutama Vol. 5 No. 01 Oktober (2023): Jurnal Medika Hutama
Publisher : Yayasan Pendidikan Medika Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hypersensitive Pneumonitis (HP) is an inflammatory lung disease caused by type 3 and 4 hypersensitivity reactions to allergens present in the environment and arises after chronic exposure, usually associated with inhaled residential or occupational allergens. The disease is relatively difficult and rare, but can cause significant and irreversible disability. The presence of pulmonary fibrosis on HRCT has important implications for prognosis and management. Patients with HP should be monitored regularly to assess progression. As far as possible, trigger antigens should be avoided. Immunosuppression is commonly used in the treatment of HP but has not been shown to slow the progression of fibrosing disease. Nintedanib, a tyrosine kinase inhibitor, is an approved treatment option for fibrotic HP with a progressive phenotype. Keywords: Hypersensitivity pneumonitis, HRCT, management
Crohn Disease: Patofisiologi, Diagnosis, dan Penatalaksanaan Nurul Utami, Herdiana; Ira Munirah; Latifah Mukhlisatunnafsi; Marwa Zileikhadira Manzalina; Yusra Pintaningrum; Jaini Rahma
Lombok Medical Journal Vol. 2 No. 2 (2023): Lombok Medical Journal Volume 2 Nomor 2
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i1.2340

Abstract

ABSTRAK Penyakit Crohn adalah kondisi radang usus idiopatik kronis, ditandai dengan lesi, yang dapat memengaruhi seluruh saluran cerna mulai dari mulut hingga anus. Insiden tahunan penyakit crohn mencapai 3 hingga 20 kasus per 100.000 dengan usia rata-rata 30 tahun. Patofisiologi penyakit crohn didasarkan pada peradangan jaringan oleh respons imun yang tidak dapat dikendalikan terhadap antigen bakteri. Penegakan diagnosis dengan Computed tomography (CT), magnetic resonance imaging (MRI), dan ultrasonografi menjadi standar diagnosis dari penyakit crohn. Prognosis dari penyakit crohn ini tergantung dari komplikasi yang muncul seperti fistula dan bowel obstruction usus serta kondisi remisi dari pasien, ataupun tingkat respon tiap pasien terhadap pengobatan sehingga dalam menangani penyakit crohn adalah mengobati kondisi peradangan aktif hingga cepat mengalami remisi dan mempertahankannya selama mungkin. Kata Kunci: crohn disease; patofisiologi; diagnosis; penatalaksanaan; prognosis ABSTRACT Crohn's disease is a chronic idiopathic inflammatory bowel condition, characterized by lesions, which can affect the entire gastrointestinal tract from the mouth to the anus. The annual incidence of Crohn's disease is 3 to 20 cases per 100,000 with a median age of 30 years. The pathophysiology of Crohn's disease is based on tissue inflammation by an uncontrollable immune response to bacterial antigens. Computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography have become the standard for the diagnosis of Crohn's disease. The prognosis of Crohn's disease depends on complications such as enteric fistula and intestinal neoplasia and the condition of remission of the patient, or the level of response of each patient to treatment so that in treating Crohn's disease is to treat the active inflammatory condition until it goes into remission quickly and maintain it as long as possible. Keyword: crohn disease; pathophysiology; diagnosis; treatment; prognosis
Potensi Senyawa Kuersetin dalam Daun Jambu Biji (Psidium guajava L.) sebagai Pengobatan Demam Berdarah Dengue Safitri, Nasywa Aulia; Marwa Zileikhadira Manzalina; Muhammad Farras Abiyyu F; Nasyada Fadhila Rahmadini; Mahacita Andanalusia
Lombok Medical Journal Vol. 2 No. 3 (2023): Lombok Medical Journal Volume 2 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i2.2851

Abstract

Abstract: Dengue is one of the most common mosquito-borne diseases in tropical and subtropical climates. So far there are no effective antivirals available for the treatment of DENV infection, which in this case requires alternative treatments that can be a cure as well as prevention for dengue fever. Alternative treatment that can be used is by using plants, one of which is guava. In guava leaves, there are various compounds that are efficacious as anti-dengue fever, namely flavonoid compounds such as quercetin and tannins which are believed to inhibit the growth of dengue viruses. The purpose of writing this manuscript is to discuss the potential of quercetin compounds in guava leaves in the management of dengue fever. Keywords: Dengue hemorrhagic fever, alternative medicine, antiviral, guava leaf, quercetin, ethnomedicine
Crohn Disease: Patofisiologi, Diagnosis, dan Penatalaksanaan Nurul Utami, Herdiana; Ira Munirah; Latifah Mukhlisatunnafsi; Marwa Zileikhadira Manzalina; Yusra Pintaningrum; Jaini Rahma
Lombok Medical Journal Vol. 2 No. 2 (2023): Lombok Medical Journal Volume 2 Nomor 2
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i1.2340

Abstract

ABSTRAK Penyakit Crohn adalah kondisi radang usus idiopatik kronis, ditandai dengan lesi, yang dapat memengaruhi seluruh saluran cerna mulai dari mulut hingga anus. Insiden tahunan penyakit crohn mencapai 3 hingga 20 kasus per 100.000 dengan usia rata-rata 30 tahun. Patofisiologi penyakit crohn didasarkan pada peradangan jaringan oleh respons imun yang tidak dapat dikendalikan terhadap antigen bakteri. Penegakan diagnosis dengan Computed tomography (CT), magnetic resonance imaging (MRI), dan ultrasonografi menjadi standar diagnosis dari penyakit crohn. Prognosis dari penyakit crohn ini tergantung dari komplikasi yang muncul seperti fistula dan bowel obstruction usus serta kondisi remisi dari pasien, ataupun tingkat respon tiap pasien terhadap pengobatan sehingga dalam menangani penyakit crohn adalah mengobati kondisi peradangan aktif hingga cepat mengalami remisi dan mempertahankannya selama mungkin. Kata Kunci: crohn disease; patofisiologi; diagnosis; penatalaksanaan; prognosis ABSTRACT Crohn's disease is a chronic idiopathic inflammatory bowel condition, characterized by lesions, which can affect the entire gastrointestinal tract from the mouth to the anus. The annual incidence of Crohn's disease is 3 to 20 cases per 100,000 with a median age of 30 years. The pathophysiology of Crohn's disease is based on tissue inflammation by an uncontrollable immune response to bacterial antigens. Computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography have become the standard for the diagnosis of Crohn's disease. The prognosis of Crohn's disease depends on complications such as enteric fistula and intestinal neoplasia and the condition of remission of the patient, or the level of response of each patient to treatment so that in treating Crohn's disease is to treat the active inflammatory condition until it goes into remission quickly and maintain it as long as possible. Keyword: crohn disease; pathophysiology; diagnosis; treatment; prognosis
Potensi Senyawa Kuersetin dalam Daun Jambu Biji (Psidium guajava L.) sebagai Pengobatan Demam Berdarah Dengue Safitri, Nasywa Aulia; Marwa Zileikhadira Manzalina; Muhammad Farras Abiyyu F; Nasyada Fadhila Rahmadini; Mahacita Andanalusia
Lombok Medical Journal Vol. 2 No. 3 (2023): Lombok Medical Journal Volume 2 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i2.2851

Abstract

Abstract: Dengue is one of the most common mosquito-borne diseases in tropical and subtropical climates. So far there are no effective antivirals available for the treatment of DENV infection, which in this case requires alternative treatments that can be a cure as well as prevention for dengue fever. Alternative treatment that can be used is by using plants, one of which is guava. In guava leaves, there are various compounds that are efficacious as anti-dengue fever, namely flavonoid compounds such as quercetin and tannins which are believed to inhibit the growth of dengue viruses. The purpose of writing this manuscript is to discuss the potential of quercetin compounds in guava leaves in the management of dengue fever. Keywords: Dengue hemorrhagic fever, alternative medicine, antiviral, guava leaf, quercetin, ethnomedicine
Co-Authors Ira Munirah Jaini Rahma Latifah Mukhlisatunnafsi Mahacita Andanalusia Muhammad Farras Abiyyu F Nasyada Fadhila Rahmadini Nurul Utami, Herdiana Safitri, Nasywa Aulia Yusra Pintaningrum