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All Journal JURNAL FARMASIMED (JFM) Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Indah Sains dan Klinis
Salmah Handayani Lubis
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Dentistry Education Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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Journal : JURNAL FARMASIMED (JFM)

 1 
Antidiarrheal Activity Test of a Combination of Guava Leaf Extract (Psidium guajava  L.) and Kencur Rhizome (Kaempferia galanga) on Male Mice (Mus musculus) Salmah Handayani Lubis; Muharni Saputri; Ika Julianti Tambunan; Adilla Apriliani; Della Aisyah Syah Fitri
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/m2vf9674

Abstract

Background Diarrhea is the leading cause of high morbidity and mortality in children in developing countries such as Indonesia. Diarrhea can be caused by bacterial infections. Guava leaves and kencur have astringent properties that can help reduce the frequency of bowel movements and stop diarrhea. Aim: The study aims to determine the most effective dose concentration of a combination of guava leaf ethanol extract (PGEE) and kencur rhizome ethanol extract (KGEE) as an antidiarrheal medicine. Methods: The study used an experimental method with stages of simplisia preparation, extract preparation by maceration, simplisia characteristics, phytochemical screening, and antidiarrheal efficacy testing using 25 male mice divided into 5 groups, namely F1 = negative control (NaCMC); F2 = positive control (Loperamide); F3, F4, and F5 were combinations (PGEE:KGEE) with 3 different dose concentrations, namely (25%:75%); (50%:50%), and (75%:25%), where the base doses used were (PGEE=400mg/kg/BW) and (KGEE=27.5mg/kgBW). Results: The parameters observed included the onset time of diarrhea, duration, frequency of bowel movements, and stool consistency. Statistical data analysis was performed using ANOVA and Tukey's post hoc test with the help of SPSS software. Statistical analysis with Tukey's post hoc test showed that there was a significant difference (p < 0.05) in fecal weight between the treatment group and the negative control group. Conclusion: The dose concentration (50%:50%) showed the most significant effect in reducing fecal weight comparable to loperamide, so that the combination of PGEE and KGEE at that dose concentration proved to be the most effective in reducing fecal weight and overcoming diarrhea, both visually (graph) and based on statistical analysis results.
Formulation and Evaluation Of Sunscreen Foundation Cream Containing Jackfruit Seed (Artocarpus heterophyllus L.) Extract As A Natural Uv Protective Agent Julianty, Siti Muliani; Salmah Handayani Lubis; Jenti Najira Siregar
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/j505xc75

Abstract

Background:: The utilization of natural ingredients in the cosmetic industry has increased significantly as consumers tend to prefer products that are safe and environmentally friendly. Jackfruit seeds (Artocarpus heterophyllus L.) are known to contain various bioactive compounds, including alkaloids, flavonoids, saponins, and tannins, which are reported to have potential photoprotective properties against ultraviolet (UV) radiation. Objective: This study aimed to evaluate the potential of ethanol extract from jackfruit seeds as an active ingredient in the formulation of a foundation cream with sunscreen activity based on the Sun Protection Factor (SPF) value. Methods: This research employed a laboratory-based experimental approach. The jackfruit seed simplicia were first dried and then extracted using analytical grade ethanol (p.a.). The obtained extract was subjected to phytochemical screening to identify the presence of secondary metabolites. Furthermore, the extract was formulated into foundation cream preparations with concentrations of 2%, 4%, and 6%. The prepared formulations were evaluated through several parameters including homogeneity, pH, spreadability, adhesion, and  determination of SPF values using a UV-Vis spectrophotometer. Results: Phytochemical screening results indicated that the ethanol extract of jackfruit seeds contained alkaloids, flavonoids, saponins, and tannins. All formulations produced homogeneous preparations with pH values ranging from 4.5 to 6.5. The spreadability values were within the range of 6.0–6.7 cm, while adhesion ranged from 7.97 to 11.63 seconds, which met the standard requirements for topical preparations. The SPF values increased proportionally with the extract concentration, showing values of 0.816 for the blank formulation, 4.38 for F1, 5.92 for F2, and 6.52 for F3. Conclusion: The ethanol extract of jackfruit seeds demonstrated potential as an active ingredient in foundation cream formulations with sunscreen activity. These findings indicate an opportunity for the development of innovative natural-based cosmetic products that provide protective effects against ultraviolet radiation.
Co-Authors Adilla Apriliani Della Aisyah Syah Fitri Elsya Sri Hidayati Ernawaty Ginting Hafizurrahman, Hafizurrahman Hardyanto Napitupulu, Ika Julianti Tambunan Jenti Najira Siregar Julianty, Siti Muliani Muflihah Fujiko Muharni Saputri Rindi Dwi Sakiki