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All Journal Sains Medisina Jurnal Riset Ilmu Kesehatan Umum dan Farmasi
Femmy Andrifianie
Universitas Lampung
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pola Penggunaan Antibiotik pada Pasien Demam Tifoid di Fasilitas Pelayanan Kesehatan: Literature Review Desi Astri; Citra Yuliyanda Pardilawati; Femmy Andrifianie; Rasmi Zakiah Oktarlina
Sains Medisina Vol 4 No 4 (2026): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v4i4.1070

Abstract

Demam tifoid masih menjadi masalah kesehatan di negara berkembang, termasuk di Indonesia. Antibiotik merupakan terapi utama, namun penggunaan yang tidak rasional dapat meningkatkan risiko resistensi bakteri. Menganalisis pola penggunaan antibiotik dan rasionalitas terapi pada pasien demam tifoid di fasilitas pelayanan kesehatan. Penelitian ini menggunakan metode literature review terhadap artikel original research yang diperoleh dari Google Scholar dan PubMed. Kriteria inklusi meliputi artikel open access, full-text, terbit pada tahun 2021–2026, dan relevan dengan topik. Sebanyak 10 artikel dianalisis secara mendalam. Pola penggunaan antibiotik didominasi oleh sefalosporin generasi III, terutama ceftriaxone dan cefixime, yang memiliki efektivitas klinis yang tinggi. Namun, rasionalitas penggunaan masih bervariasi, terutama terkait durasi terapi dan pemilihan antibiotik. Selain itu, peningkatan kasus resistensi Salmonella typhi, termasuk multidrug-resistant (MDR) dan extensively drug-resistant (XDR), menjadi tantangan dalam terapi. Dari aspek farmakoekonomi, ceftriaxone lebih cost-effective dibandingkan antibiotik lain, meskipun beberapa di antaranya memiliki efektivitas klinis yang lebih tinggi. Pola penggunaan antibiotik pada demam tifoid cenderung seragam, namun rasionalitasnya belum optimal. Kepatuhan terhadap pedoman terapi dan evaluasi penggunaan antibiotik perlu ditingkatkan secara berkelanjutan untuk mencegah resistensi dan meningkatkan kualitas pelayanan kesehatan.
Potensi Aktivitas Antidiabetes Berbagai Jenis dan Varian Tanaman Mangga (Mangifera spp.) Agnes Monica Murisla; Zulpakor Oktoba; Femmy Andrifianie; Ramadhan Triyandi
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 2 (2025): April : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i2.595

Abstract

Diabetes mellitus is a chronic disease with a significantly increasing global prevalence, especially in developing countries. Current treatments use synthetic antidiabetic drugs that are generally expensive and have various side effects. This study aims to examine the potential of mango plants (Mangifera spp.) as antidiabetic agents through a systematic literature review. Literature searches were conducted through the electronic databases PubMed and Google Scholar using the keywords "Mangifera/mango" and "antidiabetic". From the search results, 25 relevant articles were obtained for further review, consisting of 15 articles on in vitro testing and 10 articles on in vivo testing. The search results identified 17 mango plant variants worldwide that have been shown to have antidiabetic activity. Each mango species has unique characteristics and different nutritional content and bioactive compounds. Various parts of the mango plant, including leaves, fruits, seeds, and bark, contain bioactive compounds such as flavonoids, tannins, saponins, and terpenoids. These compounds contribute to antidiabetic activity through several mechanisms, namely inhibition of α-glucosidase and α-amylase enzymes, increased insulin sensitivity, and reduced blood glucose levels. Mango plant secondary metabolites are not only effective, but also have the potential to be an alternative antidiabetic treatment that is more affordable and safe compared to synthetic drugs. It can be concluded that Mangifera spp. has great potential to be developed as an innovative diabetes therapy. Further research through clinical trials is needed to confirm its effectiveness as an antidiabetic agent.
Co-Authors Agnes Monica Murisla Citra Yuliyanda Pardilawati Desi Astri Oktoba, Zulpakor Ramadhan Triyandi Rasmi Zakiah Oktarlina