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All Journal Jurnal Anestesi Perioperatif E-Journal Widya Kesehatan dan Lingkungan GHIDZA: Jurnal Gizi dan Kesehatan Jurnal Riset Kesehatan Poltekkes Depkes Bandung Poltekita : Jurnal Ilmu Kesehatan Jurnal Prima Medika Sains Jurnal Sains, Teknologi dan Kesehatan
Napitupulu, Olivia Des Vinca Albahana
Department Of Biomedicine, University Of Prima Indonesia, Medan, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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PATOGENESIS DAN TATALAKSANA PASIEN SEPSIS DENGAN DISSEMINATED INTRAVASCULAR COAGULATION Napitupulu, Olivia Des Vinca Albahana; Budipratama, Dhany
E-Journal Widya Kesehatan dan Lingkungan Vol. 1 No. 3 (2020)
Publisher : E-Journal Widya Kesehatan dan Lingkungan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sepsis adalah disfungsi organ yang mengancam jiwa akibat disregulasi respons tubuh terhadap infeksi yang menjadi salah satu penyebab kematian yang tinggi di unit perawatan intensif. Pada sepsis reaksi inflamasi sistemik yang terjadi akan mengaktivasi sistem koagulasi dan meningkatkan konsumsi faktor pembekuan, sehingga akan menimbulkan komplikasi yang serius yaitu gangguan koagulopati, yang disebut Disseminated Intravascular Coagulation (DIC). Tujuan dari penelitian ini adalah merangkum perkembangan patogenesis baru dan dampaknya terhadap tatalaksana DIC pada pasien sepsis saat ini dan di masa depan. Metode yang digunakan adalah pendekatan kuantitatif. Seperti yang diketahui, pada 35% kasus sepsis berat akan disertai dengan DIC, dan pada kasus syok sepsis, DIC menyebabkan tingginya mortalitas yang dikaitkan dengan meningkatnya keparahan penyakit, dan keseriusan kegagalan organ dengan hasil akhir yang buruk. Oleh karena itu, sangatlah penting untuk mengkaji informasi yang tersedia dalam literatur tentang pendekatan dan tatalaksana DIC pada sepsis. Dapat disimpulkan bahwa DIC merupakan suatu sindroma klinikopatologi yang merupakan komplikasi dari beragam penyakit yang ditandai dengan adanya aktivasi koagulasi darah sistemik, produksi fibrin intravaskular, sehingga dapat menyebabkan thrombosis pembuluh darah yang berukuran kecil dan sedang, bahkan dapat menyebabkan kegagalan fungsi organ bersamaan dengan konsumsi trombosit dan faktor koagulasi yang mengakibatkan gambaran klinis perdarahan.
PLASMAFARESIS PADA PASIEN STATUS EPILEPTIKUS AKIBAT ENSEFALITIS ANTI- NMDAR DI UNIT PERAWATAN INTENSIF Olivia Des Vinca; Nurita Dian Kestriani; Dhany Budipratama
Jurnal Anestesi Perioperatif Vol 8, No 1 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (428.474 KB) | DOI: 10.15851/jap.v8n1.1978

Abstract

Sejak tahun 2007 penyebab lain ensefalitis diketahui adalah autoimmun selain virus sebagai penyebab terbanyak (69%) dengan angka kematian di dunia 8–18,45%. Ensefalitis anti-NMDAR adalah ensefalitis autoimun akibat reaksi antibodi terhadap antigen membran ekstraseluler, subunit NR1, yaitu reseptor glutamat NMDA di sinapsis susunan saraf pusat. Kasus ensefalitis NMDAR sangat jarang dijumpai, berdasarkan penelitian yang teridentifikasi hanya 1% pasien usia 18–35 tahun yang dirawat di Unit Perawatan Intensif (UPI), namun dengan penatalaksanaan yang tepat dapat meningkatkan prognosis pasien. Pasien laki-laki, usia 36 tahun dikonsulkan ke UPI RSHS setelah 10 hari rawatan di Neuro High Care (NHC) pada bulan Agustus 2019 dengan penurunan kesadaran disertai riwayat kejang berulang dengan diagnosis ensefalitis anti-NMDAR. Kombinasi obat anti-viral, anti-epilepsi, dan metilprednisolon yang diberikan sebelumnya di ruangan tidak memberikan perbaikan klinis bermakna. Selama perawatan di UPI pasien diberikan terapi plasmafaresis dan menunjukkan perbaikan secara signifikan. Bangkitan kejang berulang dapat berupa kejang parsial, kejang generalisata dan status epileptikus. Manifestasi kejang diduga terjadi karena terbentuknya antibodi yang menyerang reseptor glutamat NMDA dengan target utama NR1. The American Society for Apheresis merekomendasikan plasmaferesis sebagai pilihan terapi utama. Simpulan, terapi plasmafaresis dalam tata laksana kasus ensefalitis anti- NMDAR merupakan pilihan tepat karena terbukti efektif dan efisien dalam perbaikan klinis pasien melalui mekanisme penurunan titer antibodi terhadap reseptor NMDA. Plasmapheresis in Patients of Epilepticus Status Patients Due to Anti-NMDAR Encephalitis in Intensive Care UnitsSince 2007 another known cause of encephalitis is autoimmune other than viruses as the most common cause (69%) with a mortality rate in the world of 8-18.45%. Anti-NMDAR encephalitis (n-Methyl-D-Aspartate receptor) is an autoimmune encephalitis due to an antibody reaction to the extracellular membrane antigen, NR1 subunit, the NMDA glutamate receptor at the synapses of the central nervous system. Cases of NMDAR encephalitis are very rare, based on studies that identified only 1% of patients aged 18-35 years who were treated in the Intensive Care Unit (ICU), but with proper management could improve the patient's prognosis.Male patient, 36 years old, was admitted to ICU RSHS after 10 days of treatment at Neuro High Care (NHC) in August 2019 with decreased consciousness accompanied by a history of recurrent seizures with a diagnosis of anti-NMDAR encephalitis. The combination of anti-viral, anti-epileptic, and methylprednisolone drugs given previously at NHC did not provide clinically meaningful improvement. During treatment at ICU, patients were given plasmafaresis therapy and showed significant improvement. Recurrent seizures can be partial seizures, generalized seizures and status epilepticus. Seizure manifestations are thought to occur due to the formation of antibodies that attack NMDA glutamate receptors with the main target NR1. The American Society for Apheresis recommends plasmapheresis as the main therapeutic choice. In conclusion, plasmafaresis therapy in the management of anti-NMDAR encephalitis cases is the right choice because it is proven effective and efficient in the clinical improvement of patients through the mechanism of decreasing antibody titers to NMDA receptors.
The effect of betel nut extract on melanin pigment levels in rats' skin exposed to Ultraviolet B radiation Putri, Aisy; Pulungan, Ica Yulianti; Napitupulu, Olivia Des Vinca Albahana
Jurnal Prima Medika Sains Vol. 6 No. 1 (2024): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i1.5454

Abstract

This study aims to analyze the effect of areca nut extract on the amount of melanin pigment in the skin of Wistar rats exposed to ultraviolet-B light. The research method used was post-test with control group design. The total sample of white rats used was 20 rats, which were divided into 4 groups with each group consisting of 5 rats. The cream preparation was made using cold cream base. The rats were then exposed to UVB with a certain intensity for 5 days, characterized by erythema as a result of UVB absorption into the epidermis. Each group of treated rats received base cream, 10% areca nut extract cream, and 15% areca nut extract cream topically for 14 days before termination on day 15. The collected data were then tabulated and analyzed. To determine significant differences or influences between the test groups, analysis was carried out with t-test or Independent Samples T-Test approach at 95% confidence level (p < 0.05). The results of the analysis showed that the administration of areca nut extract was effective in reducing the amount of melanin pigment in the skin of Wistar rats exposed to Ultraviolet-B light. From histopathological observations, the administration of areca nut extract with a concentration of 15% is effective in removing or fading melanin pigments in the skin exposed to Ultraviolet-B light and the results of damaged skin melanin pigments appear in the epidermis of rat skin barely visible grain.
Pathogenesis and management of sepsis patients with disseminated intravascular coagulation Napitupulu, Olivia Des Vinca Albahana; Budipratama, Dhany
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.6261

Abstract

Sepsis is a life-threatening organ dysfunction caused by dysregulation of the body's response to infection, and is one of the leading causes of death in intensive care units. In sepsis, the systemic inflammatory reaction that occurs activates the coagulation system and increases the consumption of clotting factors, leading to a serious complication of coagulopathy known as disseminated intravascular coagulation (DIC). DIC is a clinicopathological syndrome that is a complication of various diseases characterized by the activation of systemic blood coagulation and intravascular fibrin production, which can cause thrombosis of small- and medium-sized blood vessels and can even cause organ function failure along with the consumption of platelets and coagulation factors, resulting in a clinical picture of bleeding. In 35% of severe sepsis cases, and in shock sepsis DIC causes high mortality, which is associated with increased severity of illness and serious organ failure with poor outcomes. This article aims to summarize the evolving understanding of DIC pathogenesis in patients with sepsis and its implications for current and future management strategies.
PERANAN ZINC DAN VITAMIN E SEBAGAI ANTIOKSIDAN TERHADAP SEPSIS AKIBAT INFEKSI BAKTERI STAPHYLOCOCCUS AUREUS: SYSTEMATIC LITERATURE REVIEW Napitupulu, Olivia Des Vinca Albahana; Rusip, Gusbakti; Mutia, Maya Sari
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 17 No 1 (2025): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v17i1.2797

Abstract

Sepsis caused by S. aureus infection is a serious condition requiring effective interventions to improve clinical prognosis. This study aimed to review the role of zinc and vitamin E as antioxidants in sepsis management through a systematic literature review (SLR) following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The research procedure consists of four main stages: identification, screening, eligibility, and inclusion, followed by qualitative data analysis. The review results showed that zinc and vitamin E significantly contribute to reducing NF-κB activation and inflammation, playing a crucial role in enhancing bacterial clearance and patient survival, particularly in neonates. Vitamin E functions as an antioxidant by preventing lipid peroxidation and increasing endogenous antioxidant levels such as glutathione and superoxide dismutase (SOD). Furthermore, vitamin E exhibits anti-inflammatory effects, as evidenced by the reduction of inflammatory biomarkers, including TNF-α and IL-6, which help protect vital organs such as the lungs and liver from inflammatory damage. Zinc, on the other hand, improves immune responses and reduces excessive inflammation, indicating that these two compounds can synergistically improve clinical outcomes in sepsis patients. This finding confirms that zinc and vitamin E supplementation has the potential to serve as an effective supportive strategy in reducing oxidative stress, modulating inflammation, and improving the prognosis of sepsis caused by Staphylococcus aureus.
Peran Selenium dan Vitamin C sebagai Antioksidan dalam Mengatasi Sepsis Akibat Infeksi Bakteri Escherichia Coli : Systematic Literature Review Napitupulu, Olivia Des Vinca Albahana; Rusip, Gusbakti; Mutia, Maya Sari
Ghidza: Jurnal Gizi dan Kesehatan Vol. 9 No. 1 (2025): June
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/ghidza.v9i1.2034

Abstract

Sepsis merupakan respons sistemik yang berbahaya akibat infeksi bakteri, termasuk Escherichia coli, yang dapat menyebabkan kegagalan organ dan kematian. Stres oksidatif dan inflamasi merupakan dua faktor kunci dalam patogenesis sepsis. Penelitian ini bertujuan untuk mengevaluasi peran selenium dan vitamin C sebagai antioksidan dalam menangani sepsis akibat infeksi E. coli. Studi ini merupakan tinjauan literatur sistematis terhadap 10 artikel yang dipublikasikan antara tahun 2015–2024, dengan pendekatan eksperimen hewan, eksperimental klinis, dan kajian literatur. Data dianalisis berdasarkan tahun, metode penelitian, serta efek biologis yang dilaporkan. Selenium berkontribusi dalam meningkatkan aktivitas enzim glutathione peroxidase, menurunkan stres oksidatif, serta melindungi ginjal dari kerusakan. Vitamin C meningkatkan mikrosirkulasi, memperbaiki fungsi imun, dan berperan sebagai antioksidan protektif selama sepsis. Selenium dan vitamin C menunjukkan potensi besar sebagai terapi adjuvan dalam mengatasi sepsis akibat infeksi E. coli. Hasil kajian ini dapat menjadi dasar untuk pengembangan strategi terapi suportif berbasis antioksidan dalam praktik klinis.
COMPARATIVE ANALYSIS OF ANALGESIC ONSET AND DURATION: BUPIVACAINE WITH FENTANYL VS. BUPIVACAINE WITH MEPERIDINE IN SPINAL ANESTHESIA FOR CESAREAN SECTION Napitupulu, Olivia Des Vinca Albahana; Arifin, Hasanul; Nasution, Sani P
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 3 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, September 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i3.1797

Abstract

This study aimed to compare the onset and duration of analgesia in spinal anesthesia for cesarean section using hyperbaric bupivacaine combined with fentanyl or with meperidine. A double-blind randomized controlled trial was conducted involving sixty patients undergoing either elective or emergency cesarean section at Jejaring Hospital and H. Adam Malik General Hospital Medan. Patients were randomly assigned to receive hyperbaric bupivacaine with fentanyl or hyperbaric bupivacaine with meperidine, and the data were analyzed using appropriate statistical methods to examine differences between the groups. The findings revealed that the combination of bupivacaine with fentanyl produced a faster onset of analgesia compared to bupivacaine with meperidine, whereas the combination with meperidine provided a longer duration of analgesia. Both combinations were effective in achieving intraoperative and postoperative pain control, each offering distinct advantages. The study concludes that the choice of spinal anesthesia combination can be tailored to the clinical needs of patients, with fentanyl being preferable for rapid onset and meperidine offering prolonged analgesia.
Differences in the Effects of Red and White Dragon Fruit Extracts (Hylocereus Polyrhizus and Undatus) on the Body Weight of Mice with Obesity Erika, Yenny; Djulim, Djulim; Wijaya, Johanna Fransiska; Napitupulu, Olivia Des Vinca Albahana
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 4 (2024): February
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i4.3593

Abstract

Obesity causes many severe diseases. Thus, prevention efforts must include regulating body weight, increasing physical condition, or using natural goods like plant medicine in pure compounds with antioxidants. This study examined whether red and white dragon fruit extracts (Hylocereus polyrhizus and undatus) reduced body weight in obese Wistar rats (Rattus norvegicus). This type of research is quantitative, with true experiments. The samples used were 24 Wistar mice. The research treatment groups were negative control, positive control, group 3 with Red Dragon Fruit Extract 100 mg/BW/day, and group 4 with White Dragon Fruit Extract 130 mg/BW/day. The research procedures started with the acclimatization of test animals, phytochemical processes, increasing the body weight of mice, monitoring body weight, and testing leptin and FFA levels. The research data was processed using SPSS. This study found that extracts from red and white dragon fruit extracts reduced FFA better and substantially impacted leptin levels (p = 0.010). The normality and homogeneity tests showed significance > 0.05 in each group pre-and post-test. The pre-test data probability was 0.369, and the post-test probability was 0.164 > 0.05. One-way ANOVA test results: pre-test data 0.325 > 0.05, 0.000 < 0.05. Red Dragon Fruit Extract at 100 mg/BW/day and White Dragon Fruit Extract at 130 mg/BW/day helped the treatment group lose weight, while the control group remained obese Wistar rats. The research conclusion shows that red and white dragon fruit contains tannins, flavonoids, alkaloids, steroids, terpenoids, and saponins, which can help reduce the weight of obese Wistar rats.
Co-Authors Dhany Budipratama Djulim, Djulim Erika, Yenny Gusbakti Rusip Hasanul Arifin Mutia, Maya Sari Nasution, Sani P Nurita Dian Kestriani Pulungan, Ica Yulianti Putri, Aisy Wijaya, Johanna Fransiska