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All Journal Narra J Journal of Medical Science; Jurnal Ilmu Medis Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh Journal of General Procedural Dermatology and Venereology Indonesia Indonesian Journal of Case Reports
Handriani, Risna
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Chronic cutaneous chromoblastomycosis: A rare case Earlia, Nanda; Maulida, Mimi; Handriani, Risna; Kamarlis, Reno Keumalazia; Pradistha, Aldilla
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Chromoblastomycosis (CBM) is a rare, chronic granulomatous and suppurative skin infection classified as a subcutaneous mycosis. CBM has a poor prognosis with a low cure rate and a high recurrence rate. The lack of scientific data regarding the diagnosis and treatment of CBM also presents a challenge for clinicians in treating this disease. Appropriate therapy can increase the cure rate and prevent disease recurrence. Case Illustration: A 66-year-old woman presented with swelling in her left arm since the last 18 years due to wood-related injuries. There were multiple well-defined hyperkeratotic verrucous plaques, papules, and nodules, measuring 6-10 cm in diameter on the left antebrachial and hand regions. Some lesions were covered with erosion and crusts. The patient also had bone malformation. Histopathological examination showed typical characteristics of CBM. The patient was treated with 100 mg Itraconazole b.i.d. for 8 months. Discussion: Clinical manifestations and histopathological examination showed typical characteristics of CBM. Bone malformation occurred due to complications in chronic cases. Facility limitations led to the inability to perform direct microscopic examination using potassium hydroxide (KOH) and fungal culture on Sabouraud's dextrose agar. After 8 weeks of treatment, the patient's lesions were improved. The patient will be evaluated every month until treatment is complete to monitor the side effects of therapy. Conclusion: CBM lesions were improved after 8 weeks of treatment. Bone malformation could occur in chronic cases. It is important to diagnose CBM correctly and provide adequate therapy for a good outcome.
A fatal case of Harlequin ichthyosis: Experience from low-resource setting Vella, Vella; Maulida, Mimi; Earlia, Nanda; Hidayati, Arie; Handriani, Risna; Gondokaryono, Srie P.; Dwiyana, Reiva F.; Doris , Ezigbo E.; Pradistha , Aldilla; Bulqiah, Mikyal
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.302

Abstract

Harlequin ichthyosis is a severe and fatal presentation of ichthyosis with an autosomal recessive inheritance. Infants with Harlequin ichthyosis have a high mortality rate, and a dismal prognosis; therefore the majority of neonates die shortly after birth from infection, heat loss, dehydration, electrolytic imbalances, or respiratory distress. The aim of this case report was to present a fatal case of Harlequin ichthyosis with no family history of any inherited skin disorder. A 3-day-old baby was presented to the emergency room with congenital abnormalities at birth, fissured hyperkeratotic skin, and thick yellow plates of scales. The parents had no history of consanguineous marriage, no relevant past medical history, and no family history of the same condition. The patient was unwell, pulse 162 times/minute, respiratory rate 48 times/minute, and axillary temperature 36.9oC. APGAR score was 8 in the 1st minute and 9 in the 5th minute. Based on the typical clinical appearance, the patient was diagnosed with Harlequin ichthyosis. Due to a lack of facility, a mutation analysis was not carried out. The patient was then transferred to the neonatal intensive care unit (NICU) and treated in a humidified incubator and medicated with intravenous antibiotics (ampicillin sulbactam 125 mg/12 hour and gentamicin 13 mg/24 hour), topically fusidic acid and mild emollients. A central venous catheter was used for intravenous access. The poor prognosis resulted in the patient dying at the age of 5-day-old. This case highlights that prenatal diagnosis is critical for early detection and disease prevention. Mutation screening for the ABCA12 gene is suggested for consanguinity marriages and with a history of ichthyosis.
Clinical Insights and Diagnostic Dilemmas: Two Cases of Livedoid Vasculitis Earlia, Nanda; Budini, Sulamsih Sri; Lestari, Wahyu; Handriani, Risna; Ismida, Fitri Dewi; Pradistha, Aldilla; Dinillah, Teuku Muhammad Muizzy; Vemulen, Dara Avinda; Athira, Athira
Indonesian Journal of Case Reports Vol. 2 No. 1 (2024): June 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v2i1.183

Abstract

Livedoid Vasculitis (LV) is a thrombo-occlusive vasculopathy involving dermal vessels, especially in the lower extremities. Clinical symptoms of LV are chronic, recurrent, scarring, and painful purpuric ulcers. Diagnosing and providing therapy for LV is a challenge because there are no standard guidelines. We present clinical insights and diagnostic approaches on two cases of LV to improve early diagnosis and prevent misdiagnosis, which were confirmed based on history, dermatological examination, and skin biopsy. In the first case, it was a woman, 23 years old, who came with complaints of a blackish-red rash appearing on both legs. There were scars on several parts of the patient's legs, which felt painful, and the legs looked swollen. On histopathological examination, fibrin deposition in the vessel walls, endothelial proliferation, and intraluminal hyaline thrombin were found. In the second case, it was a man, 19 years old, who came with complaints of pain when walking accompanied by wounds on both lower legs. On histopathological examination, fibrin deposition in the vessel walls, endothelial proliferation, and intraluminal hyaline thrombin were found. The conclusion from the histopathology results was LV. After receiving therapy, both cases showed improvement: swelling in the legs was reduced, red and black rashes began to disappear, ulcers improved, pain decreased, and scars became blurred. These two cases provide examples of success in diagnosing LV. Being able to diagnose LV early and correctly is very important so that adequate therapy can be given and good outcomes can be achieved.
Efektifitas Terapi Injeksi Kortikosteroid Intralesi Dan 5-Flurourasil Pada Penderita Keloid Lestari, Wahyu; Handriani, Risna; Pasca Faiz Ikram, Tubagus
Journal of Medical Science Vol 6 No 1 (2025): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55572/jms.v6i1.217

Abstract

Keloid adalah keluhan dermatologis umum yang diakibatkan oleh terganggunya proses penyembuhan luka normal. Meskipun ada banyak pendekatan terapeutik untuk keloid, namun tidak ada satu metode pun yang memberikan efikasi penuh. Salah satu modalitas terapi untuk keloid adalah kombinasi injeksi intralesi Triamcinolon acetonide dan 5-Fluorourasil (5-FU). Penelitian ini bertujuan untuk membandingkan efektivitas antara terapi injeksi kortikosteroid dengan kombinasi terapi injeksi triamsinolon asetat dan 5-FU terhadap perbaikan klinis keloid. Penelitian ini merupakan penelitian uji klinis desain paralel dengan matching. Populasi penelitian ini adalah seluruh penderita keloid yang berobat di poliklinik kulit dan kelamin RSUDZA Banda Aceh dengan besar sampel 12 pasien dikelompokkan dalam 2 kelompok yaitu kelompok kontrol yang mendapatkan terapi injeksi kortikosteroid intralesi dan kelompok uji yang mendapatkan kombinasi terapi injeksi kortikosteroid intralesi dan injeksi 5-Flurourasil. Berdasarkan hasil penelitian menunjukkan bahwa terapi kombinasi triamcinolon acetonide dengan 5-FU dan triamcinolon acetonide sebagai terapi keloid menunjukkan hasil yang lebih baik, tetapi tidak terdapat perbedaan signifikan antara kedua kelompok yang dinilai menggunakan Vancouver Scar Scale.
Co-Authors Athira, Athira Dinillah, Teuku Muhammad Muizzy Doris , Ezigbo E. Dwiyana, Reiva F. Earlia, Nanda Gondokaryono, Srie P. hidayati, Arie Ismida, Fitri Dewi Maulida, Mimi Mikyal Bulqiah, Mikyal Pasca Faiz Ikram, Tubagus Pradistha , Aldilla Pradistha, Aldilla Reno Keumalazia Kamarlis Sulamsih Sri Budini, Sulamsih Sri Vella, Vella Vemulen, Dara Avinda Wahyu Lestari