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All Journal FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmiah Farmako Bahari ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Farmasi Jurnal Kesehatan Saintika Meditory
Niza, Hairun
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Rationalization of Empiric Antibiotics Therapy in Patients Hospital Acquired Pneumonia at the East OKU Regional General Hospital Niza, Hairun; Hanifah, Sarah; syavira, salsabila regy
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 13, No 2 (2023): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v13i2.8942

Abstract

The use of antibiotics requires special attention to improve the quality of therapeutic results and prevent antimicrobial resistance. Through judicious administration of antibiotics, it is hoped that there will be an impact on the quality of treatment and control of microbial resistance. The method used in this research is descriptive analysis with a cross-sectional and retrospective research design, collecting data from medical record at East OKU Hospital for the period of 2016-2022.  The analysis of the rationalization of the use of empiric antibiotics therapy showed that 65 % fell into the rational category, 35 % were irrational and had a total defined daily dose (DDD) value of 70.96 DDD/100 days of hospitalization.
uni efektivitas hypnotif sedative dari ekstrak Buah tabu air (legendária sideraria) terhadap menti Jantan Putih galar swiss webster Niza, Hairun; Putri, Nadilah; Marpaung, Mauritz Pandopo; Afriliza, Dini; Wilsya, Mayaranti
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.53228

Abstract

Introduction: The rising prevalence of sleep disorders and concerns about conventional sedative medications' side effects has created an urgent need for safer therapeutic alternatives. Aims: This study investigated the sedative-hypnotic properties of Lagenaria siceraria fruit ethanol extract in a controlled laboratory setting using Swiss Webster male mice. Methods: The research employed a randomized design with 28 male mice (2-3 months old, 20-30 grams) divided into seven groups. Two control groups received either 0.5% NaCMC (negative control) or 0.013 mg/kgBW Diazepam (positive control). The remaining five experimental groups were administered L. siceraria extract at doses ranging from 21 to 49 mg/kgBW. All treatments were administered orally under controlled conditions. Statistical analysis using two-way ANOVA revealed significant differences between treatment groups (p<0.005). Result: Subsequent Duncan's test analysis demonstrated that the highest dose of L. siceraria extract (49 mg/kgBW) produced sedative-hypnotic effects comparable to the standard Diazepam treatment. This finding suggests that L. siceraria extract could potentially serve as a natural alternative to conventional sedative medications. Conclusion: The results of this study provide compelling evidence for the sedative-hypnotic properties of L. siceraria extract, warranting further investigation into its mechanism of action and potential therapeutic applications. Future research should focus on establishing optimal dosing regimens and evaluating long-term safety profiles before clinical implementation can be considered.
PENGARUH PEANUT BALL (NON FARMAKOLOGI) DENGAN INTENSITAS NYERI PERSALINAN KALA I FASE AKTIF PADA PRIMIGRAVIDA Anggraini, Helni; Yunola, Satra; Niza, Hairun; Pebriani, Sintiya Halisya
Jurnal Kesehatan Saintika Meditory Vol 7, No 2 (2024): November 2024
Publisher : STIKES Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jsm.v7i2.2938

Abstract

Peanut ball merupakan bola yang berbentuk seperti kacang, penggunaan peanut ball diletakkan tepat di antara kaki sehingga kedua kaki dapat membuka otot panggul untuk membantu penurunan nyeri persalinan dan meningkatkan kemajuan persalinan. Tujuan penelitian untuk mengetahui pengaruh Peanut Ball Dengan Intensitas Nyeri Persalinan Kala I Fase Aktif. Jenis penelitian quasy experiment dengan one group pretest and posttest design. Populasi ibu yang bersalin di TPMB Rusmalenidari bulan Juni – September, menggunakan teknik purposive sampling. Hasil penelitian berdasarkan uji shapiro wilk pengetahuan p- data nyeri sebelum dan sesudah diberi intevensi (peanut ball) berdistribusi normal dengan sig > 0,05. Berdasarkan uji didapatkan sig <0, 05 artinya terdapat pengaruh penggunaan peanut ball terhadap penurunan intensitas nyeri. diharapkan bidan di TMB untuk memberikan terapi non farmakologi peanut ball untuk menurunkan intesitas nyeri persalinan kala I pada fase aktif.
PENGARUH PEANUT BALL (NON FARMAKOLOGY) DENGAN PERCEPATAN KALA I PADA IBU PRIMIGRAVIDA DI TPMB Yunola, Satra; Anggraini, Helni; Pebriani, Sintiya Halisya; Niza, Hairun
Jurnal Kesehatan Saintika Meditory Vol 7, No 2 (2024): November 2024
Publisher : STIKES Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jsm.v7i2.2937

Abstract

Peanut ball adalah Bola yang digunakan dalam terapi fisik atau latihan sederhana yang berbentuk seperti kacang. Penggunaan peanut ball diletakkan tepat di antara kaki wanita sehingga kedua kaki dapat membuka otot panggul untuk meningkatkan kemajuan persalinan dan memfasilitasi penurunan kepala janin. Tujuan penelitian ini adalah untuk mengetahui pengaruh peanut ball dengan percepatan kala pada ibu primigravida. Jenis penelitian Penelitian ini menggunakan metode penelitian Pre Eksperimen Yang bersifat Analitik dengan Desain atau pendekatan Intact - Group Comparison Pre Eksperimen. Sampel dalam penelitian ini sebanyak 30 responden. Pengumpulan data dalam penelitian ini menggunakan data primer di PMB dan SOP. Hasil penelitian terdapat pengaruh Peanut Ball dengan percepatan kala I dengan nilai p-value 0,002, diharapkan agar ibu hamil trimester III untuk melakukan gerakan peanut ball untuk mempercepat proses persalinan.
Tingkat Pengetahuan dan Rasionalitas Swamedikasi Pasien Penyakit Gastritis di Apotek Kota Palembang Niza, Hairun; Rahayu, Kintan Putri; Soyata, Amelia; Afriliza, Dini; Rachman, Abu
Jurnal Ilmiah Farmako Bahari Vol 16 No 2 (2025): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v16i2.41936

Abstract

Masyarakat banyak melakukan swamedikasi dalam menangani keluhan atau gejala penyakit ringan. Dalam melakukan swamedikasi, penggunaan obatnya harus memenuhi kriteria rasional. Kurangnya pengetahuan tentang swamedikasi mengakibatkan terjadinya medication error. Gastritis merupakan salah satu dari penyakit yang dapat diobati secara swamedikasi. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan responden dan rasionalitas dalam penggunaan obat. Metode yang digunakan pada penelitian observasional deskriptif dengan metode survei cross sectional. Data diambil melalui pengisian kuesioner oleh responden yang melakukan swamedikasi Gastritis di 3 apotek Kota Palembang, yang masuk dalam kriteria inklusi. Jenis kuesioner yang digunakan adalah Guttman. Data diolah menggunakan uji chi-square. Hasil penelitian menyatakan tingkat pengetahuan pasien pada swamedikasi Gastritis berkategori Baik sebanyak 52,3% dan yang berkategori kurang baik sebanyak 47,7%. Mayoritas pasien sebanyak 59% melakukan swamedikasi secara tidak rasional dan 41% secara rasional. Hasil pengujian chi-square antara tingkat pengetahuan dan rasionalitas mendapat p value (,000) yang artinya terdapat hubungan. Tingkat pengetahuan terhadap sosiodemografi memiliki hubungan pada kategori jenis kelamin, pendidikan dan pekerjaan dengan p value <0,05. Namun tidak memiliki hubungan terhadap kategori usia karena p value >0,05. Berdasarkan hasil penelitian dapat disimpulkan tingkat pengetahuan pasien tergolong baik 52,3% dan rasionalitas penggunaan obat tergolong tidak tepat 59%.
OPTIMASI DOSIS EKSTRAK ETANOL BUAH DUKU (Lansium Domestikum Corr.) UNTUK EFEKTIVITAS DIURETIK TERHADAP TIKUS JANTAN GALUR WISTAR Niza, Hairun; Fahrozi, Hikmal
Jurnal Farmasi (Journal of Pharmacy) Vol. 13 No. 1 (2024): Jurnal Farmasi (Journal of Pharmacy), April 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/5vw7jd96

Abstract

Research has been carried out on optimizing the dose of ethanol extract of Duku fruit (Lansium domesticum corr) for the effectiveness of diuretics in male Wistar rats. This research uses quantitative methods. The animals used in this research were 25 male Wistar rats and were divided into 5 groups that had passed the acclimation period and had passed the urine volume collection period. Each group was given a different preparation, group I negative control was Na-CMC 0.5%, group II positive control furosemide 36 mg/kgBB, group III ethanol extract of duku fruit 50 mg/kgBB, group IV ethanol extract of duku fruit 100 mg /kgBW, and group V extra ethanol duku fruit 150 mg/kgBB. Urine volume measurements were carried out on days 8 to 21 every 12 hours. The data obtained were analyzed using statistical tests, Levene's test, Shapiro Wilk, two-way anova, and post hoc tests. The results of this study show that a dose of 150 mg/kgBB has diuretic activity in duku fruit plants with the average volume of urine collected in the 2nd week being 7.46 ± 3.27, in the 3rd week the average volume urine 9.92 ± 3.11. In the positive control, furosemide as a comparison, the average urine volume was 6.21 ± 3.56 in the 2nd week and in the 3rd week, the average urine volume was 8 ± 3.60.
Co-Authors Afriliza, Dini Fahrozi, Hikmal Hanifah, Sarah HELNI ANGGRAINI Marpaung, Mauritz Pandopo Pebriani, Sintiya Halisya Putri, Nadilah Rachman, Abu Rahayu, Kintan Putri Soyata, Amelia syavira, salsabila regy Wilsya, Mayaranti Yunola, Satra