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All Journal Indonesian Journal of Health Science Medical Sains : Jurnal Ilmiah Kefarmasian
Dhigna Luthfiyani Citra Pradana
Universitas Pembangunan Nasional Veteran Jakarta
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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IN VITRO ACUTE TOXICITY OF DANDELION LEAF EXTRACT (Taraxacum officinale F.H.Wigg) WITH BRINE SHRIMP LETHALITY TEST (BSLT) METHOD Dian Mega Sugiyarto; Annisa Farida Muti; Dhigna Luthfiyani Citra Pradana; Eldiza Puji Rahmi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.873

Abstract

Toxicity is a characteristic feature of substances that can cause harmful effects. This study aimed to determine the toxicity of dandelion leaves (Taraxacum officinale F.H. Wigg) to Artemia salina Leach larvae within 24 hours. Dandelion leaves were extracted using a maceration method with 50% ethanol. The yield was 5.88%. The results showed that dandelion leaves contain alkaloids, flavonoids, steroids, triterpenoids, and phenols. Toxicity tests were performed using the Brine Shrimp Lethality Test method, where the final result was the LC50 value. Artemia salina Leach larvae were divided into five groups. Each group had ten larvae that underwent three replications. The 50%ethanolic extract of dandelion leaf concentrations in the treatment media were 50 ppm (P1), 100 ppm (P2), 150 ppm (P3), 200 ppm (P4), and 0 ppm (seawater) as the control. Probit analysis of Artemia Salina Leach mortality percentage data. The results indicated that the 50%ethanolic extract of dandelion leaves is harmful to larvae, with LC50 values of 165,223 ppm (toxic) or in the equation y = 2,114x + 0,311, with an R² value of 0,9435. Keywords: Artemia salina, BSLT, Dandelion leaf, LC50, Toxicity
Andaliman fruit (Zanthoxylum acanthopodium dc) from Sumatera can help reduce blood glucose: Glucose tolerance test Mutia Salsabila Rosyianti; Isyah Radhiyah Saidek; Nindya Nur Amalina; Regalita Novia; Dhigna Luthfiyani Citra Pradana
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.2082

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to impaired insulin secretion or action. The utilization of natural products as antihyperglycemic agents continues to be explored, including andaliman fruit (Zanthoxylum acanthopodium DC.), an endemic plant from Sumatra known to contain bioactive compounds such as flavonoids and saponins. This study aimed to evaluate the antihyperglycemic potential of ethanolic extract of andaliman fruit using an oral glucose tolerance test in male mice. An experimental design was applied with three groups: negative control (distilled water), positive control (glibenclamide), and ethanolic extract of andaliman fruit at a dose of 20 mg/kgBW. Blood glucose levels were measured before and after glucose induction up to 90 minutes. Data were analyzed using One Way ANOVA followed by the Bonferroni post hoc test. The results demonstrated a significant difference among treatment groups (F(2,6) = 19.344; p = 0.002). Post hoc analysis revealed that the andaliman extract significantly differed from the negative control (p = 0.024), but showed no significant difference compared to glibenclamide (p = 0.196). In conclusion, the ethanolic extract of andaliman fruit exhibits antihyperglycemic potential with statistically comparable effectiveness to glibenclamide in a glucose tolerance model. These findings support further development of andaliman as a potential phytopharmaceutical antidiabetic agent derived from local natural resources.
Co-Authors Annisa Farida Muti Dian Mega Sugiyarto Isyah Radhiyah Saidek Mutia Salsabila Rosyianti Nindya Nur Amalina Rahmi, Eldiza Puji Regalita Novia