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All Journal Indonesian Journal of Health Science Kenduri: Jurnal Pengabdian Dan Pemberdayaan Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian
Dhigna Luthfiyani Citra Pradana
Universitas Pembangunan Nasional Veteran Jakarta
Humanities Dentistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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IN VITRO ACUTE TOXICITY OF DANDELION LEAF EXTRACT (Taraxacum officinale F.H.Wigg) WITH BRINE SHRIMP LETHALITY TEST (BSLT) METHOD Dian Mega Sugiyarto; Annisa Farida Muti; Dhigna Luthfiyani Citra Pradana; Eldiza Puji Rahmi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.873

Abstract

Toxicity is a characteristic feature of substances that can cause harmful effects. This study aimed to determine the toxicity of dandelion leaves (Taraxacum officinale F.H. Wigg) to Artemia salina Leach larvae within 24 hours. Dandelion leaves were extracted using a maceration method with 50% ethanol. The yield was 5.88%. The results showed that dandelion leaves contain alkaloids, flavonoids, steroids, triterpenoids, and phenols. Toxicity tests were performed using the Brine Shrimp Lethality Test method, where the final result was the LC50 value. Artemia salina Leach larvae were divided into five groups. Each group had ten larvae that underwent three replications. The 50%ethanolic extract of dandelion leaf concentrations in the treatment media were 50 ppm (P1), 100 ppm (P2), 150 ppm (P3), 200 ppm (P4), and 0 ppm (seawater) as the control. Probit analysis of Artemia Salina Leach mortality percentage data. The results indicated that the 50%ethanolic extract of dandelion leaves is harmful to larvae, with LC50 values of 165,223 ppm (toxic) or in the equation y = 2,114x + 0,311, with an R² value of 0,9435. Keywords: Artemia salina, BSLT, Dandelion leaf, LC50, Toxicity
Andaliman fruit (Zanthoxylum acanthopodium dc) from Sumatera can help reduce blood glucose: Glucose tolerance test Mutia Salsabila Rosyianti; Isyah Radhiyah Saidek; Nindya Nur Amalina; Regalita Novia; Dhigna Luthfiyani Citra Pradana
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.2082

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to impaired insulin secretion or action. The utilization of natural products as antihyperglycemic agents continues to be explored, including andaliman fruit (Zanthoxylum acanthopodium DC.), an endemic plant from Sumatra known to contain bioactive compounds such as flavonoids and saponins. This study aimed to evaluate the antihyperglycemic potential of ethanolic extract of andaliman fruit using an oral glucose tolerance test in male mice. An experimental design was applied with three groups: negative control (distilled water), positive control (glibenclamide), and ethanolic extract of andaliman fruit at a dose of 20 mg/kgBW. Blood glucose levels were measured before and after glucose induction up to 90 minutes. Data were analyzed using One Way ANOVA followed by the Bonferroni post hoc test. The results demonstrated a significant difference among treatment groups (F(2,6) = 19.344; p = 0.002). Post hoc analysis revealed that the andaliman extract significantly differed from the negative control (p = 0.024), but showed no significant difference compared to glibenclamide (p = 0.196). In conclusion, the ethanolic extract of andaliman fruit exhibits antihyperglycemic potential with statistically comparable effectiveness to glibenclamide in a glucose tolerance model. These findings support further development of andaliman as a potential phytopharmaceutical antidiabetic agent derived from local natural resources.
Gambaran pengetahuan umum tentang skabies menurut pendidikan dan sumber informasi kesehatan pada peserta edukasi di Posyandu Seruni, Depok Fransiskus Samuel Renaldi; Ariska Deffy Anggarany; Annisa Farida Muti; Andiri Niza Syarifah; Aulia Farkhani; Dhigna Luthfiyani Citra Pradana
KENDURI : Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 6 No. 3 (2026): September-December
Publisher : Yayasan Darussalam Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62159/kenduri.v6i3.2983

Abstract

Scabies is a contagious skin infestation that can persist in communities when misconceptions, delayed recognition, and incomplete contact management remain unaddressed. This study described general scabies knowledge among participants of a community education activity at Posyandu Seruni, Depok, and mapped descriptive patterns according to education and health-information source. A descriptive quantitative evaluation was conducted during the activity on 9 February 2026. The broader program used a 20-item true/false questionnaire covering general scabies knowledge, pharmacological treatment, clean and healthy living behavior, and safe supportive herbal use. This manuscript analyzes the five-item general-knowledge domain because these responses were the most consistently verified. Correct answers received one point and were summarized using frequencies, percentages, mean, median, and minimum-maximum scores. Among 51 analyzable responses, the mean score was 68.2% (median 80.0%; range 20.0-100.0%). Thirty-two participants (62.7%) were categorized as having good knowledge, eight (15.7%) adequate knowledge, and 11 (21.6%) poor knowledge. Correctness was highest for transmission through shared clothes, towels, and bed sheets (82.4%) and lowest for rejecting the misconception that scabies affects only people who rarely bathe (49.0%). The highest descriptive mean by education was observed in the Diploma/Bachelor group (80.0%), while social media had the highest descriptive mean by information source (76.0%); cadres/Posyandu were the most common source (56.9%) but had a mean of 62.8%. The findings indicate a fairly good baseline with persistent stigma-related misconceptions. Targeted cadre messages and validated paired pretest-posttest evaluation are recommended; program effectiveness cannot be inferred because paired pretest-posttest data were not available for verification.
Co-Authors Andiri Niza Syarifah Annisa Farida Muti Ariska Deffy Anggarany, Ariska Deffy Aulia Farkhani Dian Mega Sugiyarto Eldiza Puji Rahmi Isyah Radhiyah Saidek Mutia Salsabila Rosyianti Nindya Nur Amalina Regalita Novia Renaldi, Fransiskus Samuel