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All Journal Journal of Innovative and Creativity Medical Sains : Jurnal Ilmiah Kefarmasian
Putri Anggreini
Universitas Mulawarman
Education Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Social Sciences Other

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FORMULATION AND NUTRITIONAL EVALUATION OF HIGH-FAT DIET FEED FOR FATTY LIVER INDUCEMENT IN RODENT MODELS Putri Anggreini; Jutti Levita; Hadi Kuncoro; Andi Tenri Kawareng; Sri Adi Sumiwi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1233

Abstract

Non-alcoholic fatty Liver Disease (NAFLD) is one of the most prevalent lipid disorders worldwide. In the pursuit of drug discovery and development, animal modeling is crucial to elucidate the mechanisms underlying a disease. One form of animal model of NAFLD involves the induction of a high-fat diet (HFD). However, most HFDs exhibit complexity in the formulation, and commercial HFDs tend to be costly. This study aimed to formulate an HFD feed with minimal ingredients that are capable of inducing liver steatosis. This study commenced with the development of 4 dietary formulations (F1, F2, F3, and F4) comprising various food components with specific proportions and treatments. A proximate analysis was conducted for each formulation. Subsequently, the most promising formulation was administered to the rats for 14 days. On day 15, liver organs were harvested for histological analysis. The results showed that among the four formulations developed, HFD F4 exhibited the best physical appearance and nutritional proximate components, characterized by its stability in form and high fat (41.8%), high protein (21.5%), and low carbohydrate (23.2%) content. Histology examination revealed that two weeks of administration of F4 administration led to severe degeneration, inflammation, and necrosis in rat hepatocytes compared to the normal group (p < 0.001), thus confirming that HFD F4 may be developed as an inducer of steatosis in rats.  Keywords: experimental animal model; high-fat diet; liver steatosis ; NAFLD
Phytochemical Screening, Antioxidant Activity, And Antimitotic Potential Of Shallot Skin (Allium Cepa L.) Extract Raisa Fadilla; Maryam Jamila Arief; Satriani Badawi; Venna Sinthary; Putri Anggreini; Leny Eka Tyas Wahyuni; Nur Rezky Khairun Nisa
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.6915

Abstract

Shallot skin (Allium cepa L.) is a by-product that is generally discarded as household waste, despite its potential as a source of bioactive compounds. Previous studies have indicated that shallot skin contains secondary metabolites with antioxidant and cytotoxic properties. This study aimed to evaluate the phytochemical composition, antioxidant activity, and antimitotic potential of shallot skin extract in order to support its valorization as a natural bioactive resource. Materials and methods. This research was conducted as an experimental laboratory study. Dried shallot skin was extracted using ethanol through a maceration method, followed by solvent evaporation to obtain a crude extract. Phytochemical screening was performed using Thin Layer Chromatography (TLC) to identify major secondary metabolites. Solvent partitioning was carried out using n-hexane and ethyl acetate, and further fractionation was conducted using vacuum column chromatography and preparative TLC. Antioxidant activity was evaluated using the DPPH radical scavenging assay, while antimitotic activity was assessed using the Brine Shrimp Lethality Test (BSLT). Results. The ethanolic extraction produced a high yield of crude extract (57.13%), indicating effective recovery of polar and semi-polar compounds. Phytochemical screening confirmed the presence of alkaloids, flavonoids, and phenolic compounds. The extract exhibited very strong antioxidant activity with an IC₅₀ value of 17.477 µg/mL. Antimitotic evaluation using BSLT showed an LC₅₀ value of 202.301 µg/mL, indicating biological activity at moderate concentrations. Conclusions. The findings demonstrate that shallot skin contains diverse secondary metabolites with strong antioxidant activity and measurable antimitotic potential. These results support the utilization of shallot skin as a valuable natural source of bioactive compounds and provide a basis for further studies on compound isolation and advanced biological evaluation.
Co-Authors Andi Tenri Kawareng Hadi Kuncoro Jutti Levita Leny Eka Tyas Wahyuni Maryam Jamila Arief Nur Rezky Khairun Nisa Raisa Fadilla Satriani Badawi Sri Adi Sumiwi Venna Sinthary