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All Journal Teknosains: Media Informasi Sains dan Teknologi Jurnal Biodjati
Maharani Retna Duhita
Department Of Biology, Faculty Of Science And Technology, UIN Maulana Malik Ibrahim Malang, Jl. Gajayana No.50, Malang, East Java, Indonesia, 65144
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Physics

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KAJIAN TEMATIK AIR PADA SIKLUS AIR MENURUT PERSPEKTIF SAINS DAN AL-QURAN Muhammad Maslan; Ahmad Muzakki; Maharani Retna Duhita; Hafsan Hafsan
Teknosains Vol 15 No 2 (2021): Mei-Agustus
Publisher : Fakultas Sains dan Teknologi Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/teknosains.v15i2.19579

Abstract

Allah SWT menurunkan al-Qur'an sebagai pedoman hidup manusia. Proses penciptaan alam adalah kekuatan Tuhan dalam menciptakan kehidupan. Allah menciptakan alam semesta yaitu langit dan bumi sebagai sarana kehidupan bagi makhluk hidup khususnya manusia. Dia menciptakan dunia ini memiliki maksud dan tujuan tertentu dengan kebenaran. Seperti ciptaan alam (air) yang memiliki manfaat bagi makhluk hidup. Tujuan dari penelitian ini adalah untuk menjelaskan mukjizat ayat-ayat al-Qur'an. Hasilnya adalah ayat tentang air yang berperan dalam siklus air yang disebut Al-Quran adalah air laut ada 33 kali, air dari langit (hujan) 32 kali dan air sungai sebanyak 48 kali, lalu siklus air dalam kebenaran ayat-ayat al-Qur'an adalah kekuasaan Allah. Jadi sebagai seorang Muslim yang beriman, ia telah menjadikan al-Qur'an sebagai pelajaran dan kekuatan iman dan pedoman hidup dalam Islam sebagai ilmuwan besar. Ilmu pengetahuan memudahkan umat Islam untuk memahami isi al-Qur'an.
Effect of Chitosan-Coated Centella asiatica Nanoparticles on Kidney Histology Profile of Complicated Diabetic Mice Bayyinatul Muchtaromah; Ana Mar'a Konita Firdaus; Eko Budi Minarno; Prilya Dewi Fitriasari; Mei Rhomawati; Maharani Retna Duhita; Wira Eka Putra
Jurnal Biodjati Vol 8, No 2 (2023): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v8i2.21430

Abstract

Gotu kola (Centella asiatica) is a medicinal plant that has potential as an antioxidant and antidiabetic. Its compound is able to protect against diabetic nephropathy through the inhibition of oxidative stress. In terms of increasing drug potency and bioavailability of C. asiatica compounds, nanoparticle technology was used. This study aimed to determine the effect of C. asiatica nanoparticles coated with chitosan on the renal histology profile of complicated diabetic mice using a completely randomized design (CRD) with five treatment groups and five replications. The treatment groups were divided into K- (the experimental animals were not given any treatment), K+ (the experimental animals were induced by STZ), P1 (STZ + C. asiatica nanoparticles 120 mg/kgBW), P2 (STZ + C. asiatica nanoparticles 180 mg/kgBW), P3 (STZ + C. asiatica nanoparticles 240 mg/kgBW). The experimental animal model of complicated diabetes was induced by intraperitoneal STZ at a dose of 40 mg/kgBW for two days and STZ at a dose of 60 mg/kgBW for three days and then left for nine days. The C. asiatica nanoparticle therapy was given for 28 days. The parameters in this study were the results of scoring cell damage in the glomerular and tubular tissues (proximal and distal) of the kidney. The data obtained were tested for normality and homogeneity, then the normal and homogeneous data were tested with one-way ANOVA and further tested with Duncan's test. The statistical analysis results showed that C. asiatica coated with chitosan nanoparticles could reduce the damage to the histological profile of the glomerulus and tubules (proximal and distal) of the kidney of diabetic mice. C. asiatica-coated nanoparticles at a dose of 240 mg/kgBW showed the most optimal reduction in damage to the glomerular and tubular histology profiles.
Co-Authors AHMAD MUZAKKI Ana Mar'a Konita Firdaus Bayyinatul Muchtaromah Eko Budi Minarno Hafsan, Hafsan Mei Rhomawati Muhammad Maslan Prilya Dewi Fitriasari Wira Eka Putra