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KAJIAN TEMATIK AIR PADA SIKLUS AIR MENURUT PERSPEKTIF SAINS DAN AL-QURAN Muhammad Maslan; Ahmad Muzakki; Maharani Retna Duhita; Hafsan Hafsan
Teknosains Vol 15 No 2 (2021): Mei-Agustus
Publisher : Fakultas Sains dan Teknologi Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/teknosains.v15i2.19579

Allah SWT menurunkan al-Qur'an sebagai pedoman hidup manusia. Proses penciptaan alam adalah kekuatan Tuhan dalam menciptakan kehidupan. Allah menciptakan alam semesta yaitu langit dan bumi sebagai sarana kehidupan bagi makhluk hidup khususnya manusia. Dia menciptakan dunia ini memiliki maksud dan tujuan tertentu dengan kebenaran. Seperti ciptaan alam (air) yang memiliki manfaat bagi makhluk hidup. Tujuan dari penelitian ini adalah untuk menjelaskan mukjizat ayat-ayat al-Qur'an. Hasilnya adalah ayat tentang air yang berperan dalam siklus air yang disebut Al-Quran adalah air laut ada 33 kali, air dari langit (hujan) 32 kali dan air sungai sebanyak 48 kali, lalu siklus air dalam kebenaran ayat-ayat al-Qur'an adalah kekuasaan Allah. Jadi sebagai seorang Muslim yang beriman, ia telah menjadikan al-Qur'an sebagai pelajaran dan kekuatan iman dan pedoman hidup dalam Islam sebagai ilmuwan besar. Ilmu pengetahuan memudahkan umat Islam untuk memahami isi al-Qur'an.

Effect of Chitosan-Coated Centella asiatica Nanoparticles on Kidney Histology Profile of Complicated Diabetic Mice Bayyinatul Muchtaromah; Ana Mar'a Konita Firdaus; Eko Budi Minarno; Prilya Dewi Fitriasari; Mei Rhomawati; Maharani Retna Duhita; Wira Eka Putra
Jurnal Biodjati Vol 8, No 2 (2023): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v8i2.21430

Gotu kola (Centella asiatica) is a medicinal plant that has potential as an antioxidant and antidiabetic. Its compound is able to protect against diabetic nephropathy through the inhibition of oxidative stress. In terms of increasing drug potency and bioavailability of C. asiatica compounds, nanoparticle technology was used. This study aimed to determine the effect of C. asiatica nanoparticles coated with chitosan on the renal histology profile of complicated diabetic mice using a completely randomized design (CRD) with five treatment groups and five replications. The treatment groups were divided into K- (the experimental animals were not given any treatment), K+ (the experimental animals were induced by STZ), P1 (STZ + C. asiatica nanoparticles 120 mg/kgBW), P2 (STZ + C. asiatica nanoparticles 180 mg/kgBW), P3 (STZ + C. asiatica nanoparticles 240 mg/kgBW). The experimental animal model of complicated diabetes was induced by intraperitoneal STZ at a dose of 40 mg/kgBW for two days and STZ at a dose of 60 mg/kgBW for three days and then left for nine days. The C. asiatica nanoparticle therapy was given for 28 days. The parameters in this study were the results of scoring cell damage in the glomerular and tubular tissues (proximal and distal) of the kidney. The data obtained were tested for normality and homogeneity, then the normal and homogeneous data were tested with one-way ANOVA and further tested with Duncan's test. The statistical analysis results showed that C. asiatica coated with chitosan nanoparticles could reduce the damage to the histological profile of the glomerulus and tubules (proximal and distal) of the kidney of diabetic mice. C. asiatica-coated nanoparticles at a dose of 240 mg/kgBW showed the most optimal reduction in damage to the glomerular and tubular histology profiles.

Effect of Chitosan-Coated Centella asiatica Nanoparticles on Kidney Histology Profile of Complicated Diabetic Mice Muchtaromah, Bayyinatul; Firdaus, Ana Mar'a Konita; Minarno, Eko Budi; Fitriasari, Prilya Dewi; Rhomawati, Mei; Duhita, Maharani Retna; Putra, Wira Eka
Jurnal Biodjati Vol 8 No 2 (2023): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v8i2.21430

Gotu kola (Centella asiatica) is a medicinal plant that has potential as an antioxidant and antidiabetic. Its compound is able to protect against diabetic nephropathy through the inhibition of oxidative stress. In terms of increasing drug potency and bioavailability of C. asiatica compounds, nanoparticle technology was used. This study aimed to determine the effect of C. asiatica nanoparticles coated with chitosan on the renal histology profile of complicated diabetic mice using a completely randomized design (CRD) with five treatment groups and five replications. The treatment groups were divided into K- (the experimental animals were not given any treatment), K+ (the experimental animals were induced by STZ), P1 (STZ + C. asiatica nanoparticles 120 mg/kgBW), P2 (STZ + C. asiatica nanoparticles 180 mg/kgBW), P3 (STZ + C. asiatica nanoparticles 240 mg/kgBW). The experimental animal model of complicated diabetes was induced by intraperitoneal STZ at a dose of 40 mg/kgBW for two days and STZ at a dose of 60 mg/kgBW for three days and then left for nine days. The C. asiatica nanoparticle therapy was given for 28 days. The parameters in this study were the results of scoring cell damage in the glomerular and tubular tissues (proximal and distal) of the kidney. The data obtained were tested for normality and homogeneity, then the normal and homogeneous data were tested with one-way ANOVA and further tested with Duncan's test. The statistical analysis results showed that C. asiatica coated with chitosan nanoparticles could reduce the damage to the histological profile of the glomerulus and tubules (proximal and distal) of the kidney of diabetic mice. C. asiatica-coated nanoparticles at a dose of 240 mg/kgBW showed the most optimal reduction in damage to the glomerular and tubular histology profiles.

Entomological Assessment of Mosquito Diversity and Density in Negara District, Bali: Implications for Vector-Borne Disease Surveillance Widyawati, Dani Sari; Duhita, Maharani Retna
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.256-263

Indonesia has one of the highest prevalences of malaria in Asia, with annual case numbers on the rise. Despite being a major international tourist destination, the Negara Sub-district in Jembrana Regency, Bali, continues to experience notable incidences of both diseases. Entomological surveys are crucial for evaluating mosquito diversity and density, which supports effective vector control strategies. This study, conducted in five villages from September to October 2024, employed entomological survey methods to calculate the House Index (HI), Container Index (CI), Breteau Index (BI), and Density Figure (DF). Mosquito species diversity was assessed using the Shannon-Wiener diversity index and evenness (E) and dominance (C) metrics. Results indicated that HI, CI, and BI values were within the low transmission risk category, with a DF of 4 and a larva-free rate (ABJ) of ≤95%. Six mosquito species were identified: Aedes aegypti, Aedes albopictus, Anopheles dirus, Armigeres subalbatus, Culex quinquefasciatus, and Mansonia uniformis. The species diversity was moderate (1 < H' ≤ 3), even species distribution (E > 0.6), and low dominance (C ≤ 0.5). These findings suggest a relatively low risk of vector-borne disease transmission. However, given the presence of multiple disease-vector species and the region's dynamic human activity, continuous entomological surveillance remains essential to anticipate population surges and strengthen disease prevention efforts.

Unveiling the Anticancer Efficacy of Kaempferol from Moringa oleifera Against Breast Cancer: Insights from an In Silico Investigation Duhita, Maharani Retna; Azhar, Vina Virlana
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 11, No 1 (2026)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v11i1.94156

Breast cancer is a significant global health problem that is often encountered in women. Kaempferol from Moringa is known to control breast cancer cells. This study explores the in silico potential of kaempferol compounds derived from Moringa oleifera as breast cancer drug candidates. The results showed that kaempferol compounds have anticarcinogenic potential, with a high Pa value of 0.715, via the target proteins CYP1B1 and HSD17B2. The prediction of physicochemical properties indicates that kaempferol is a viable oral medication candidate, as it adheres to Lipinski's rule of five. However, it is dangerous if swallowed because it is classified as toxicity class 5. Molecular docking analysis indicates that kaempferol has high affinity for the target proteins CYP1B1 and HSD17B2. It can significantly contribute to breast cancer progression, with binding energies of -7.1 kcal/mol and -6.8 kcal/mol, respectively. Hydrogen bonds and hydrophobic interactions predominated the molecular interactions between kaempferol and the target proteins. These findings suggest that kaempferol from Moringa oleifera is a promising lead compound for the development of breast cancer treatments. Despite its potential, further studies are required to mitigate its toxicity risks, as indicated by the pharmacokinetics, drug-likeness, and toxicity assessments.

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