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All Journal JURNAL KIMIA SAINS DAN APLIKASI Indonesian Journal of Chemistry Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Agritechno Makara Journal of Science Bulletin of Chemical Reaction Engineering & Catalysis
Tuti Wukirsari
Department Of Chemistry, Faculty Of Mathematics And Natural Science (FMIPA), Universitas Indonesia, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Energy Engineering Environmental Science Materials Science & Nanotechnology Mathematics Mechanical Engineering

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DIFFUSION BEHAVIOR OF KETOPROFEN THROUGH CHITOSAN-ALGINATE MEMBRANES Purwantiningsih Sugita; Rini Siswati Asnel; Budi Arifin; Tuti Wukirsari
Indonesian Journal of Chemistry Vol 10, No 3 (2010)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (416.425 KB) | DOI: 10.22146/ijc.21429

Abstract

Chitosan-alginate membrane diffusion behavior has been investigated for its application in drugs delivery system. Ketoprofen diffusion behavior assay were performed at 37 and 42 °C to membrane thickness (h) and donor cell concentration of ketoprofen variations (A). The results showed that equilibrium concentrations (Cs) of ketoprofen equation was 27.0087 + 0.09067T - 1.7499h + 0.1030A + 0.0161h2 - 0.0022A2 + 0.0040Th - 0.0018TA + 0.0095hA. The value of Cs was closer to the expected therapy concentration at 50 and 75 mg/L with thin membrane (10-34 μm). Based on Higuchi equation, the model for J and D were J = 11.0849 - 0.2713T - 0.3132h - 0.7461Cs - 0.0096A - 0.0001h2 - 0.0131Cs2 + 0.0002A2 + 0.0084Th + 0.0275TCs - 0.0018TA - 0.0059hCs + 0.0021hA + 0.0037CsA with R2 = 97.9% and D = -12.5000 + 0.2266T + 0.1313h + 0.1538Cs + 0.1200A - 0.0009h2 + 0.0240 Cs2 - 0.0009A2 + 0.0015Th - 0.0150 TCs - 0.0011TA - 0.0096hCs + 0.0004hA + 0.0039CsA with R2 = 98.7%, respectively. The two dimensional contour maps of J versus A and h, both at 37 and 42 °C, showed an increasing of J value as A, h, or T increased.
Sifat Fisikokimia Pati Tahan Cerna Hasil Hidrolisis Asam dan Heat Moisture Treatment pada Pati Maizena Tuti Wukirsari; Endang Saepuddin; Ivanka Putri Hanafiah
Jurnal Agritechno Jurnal Agritechno, Vol. 15, Number 1, April 2022
Publisher : Depertemen Teknologi Pertanian Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/at.v15i1.587

Abstract

The increasing of diabetes prevalence both in Indonesia and in the world requires innovations in the food sector. In this study, modification of corn starch was carried out by acid hydrolysis (HA) and heat moisture treatment (HMT) with various combinations of HCl concentration and duration of HMT. Then the effect of HA and/or HMT modification on the physicochemical properties of corn starch was determined. The results showed that HA and/or HMT treatment reduced digestibility up to 56%, swelling power up to 10 times, and viscosity up to 2 times in modified starch. These data prove the rearrangement of the modified corn starch granule to become denser and more crystalline.
Digestibility and Physicochemical Properties of Brown Rice and Black Glutinous Rice under a Combination of Heat-Moisture Treatments and Citric Acid Annisa Mawaddah; Endang Saepudin; Tuti Wukirsari
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 24 No. 02 (2023): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol24-iss02/370

Abstract

Brown rice and black glutinous rice are rich in nutrients and fiber the body needs. The difference between brown and black glutinous rice lies in the starch content, namely amylose, and amylopectin, which can affect digestibility. Low digestibility rice can lower blood glucose levels, so it is needed for people with diabetes and obesity. This study modified brown rice and black glutinous rice with double modification HMT-crosslinking with citric acid and Crosslinking-HMT with various variations to determine the physicochemical properties and the lowest digestibility of brown rice and black glutinous rice. Multiple modifications can reduce digestibility, but a modification of HMT 25%-Crosslinking 20% showed the lowest digestibility in black glutinous rice. Differences in amylose and amylopectin levels in the sample can cause differences in the decrease in solubility and swelling power. The lowest solubility was found in brown rice with the HMT 25%-Crosslinking 20% variation, and the lowest swelling power in the brown rice sample with the HMT 25%-Crosslinking 20% variation. The formation of new covalent bonds after the crosslinking modification process can be identified by FTIR in the 1735 cm-1 regi
ENKAPSULASI KETOPROFEN DENGAN KITOSAN-ALGINAT BERDASARKAN JENIS DAN RAGAM KONSENTRASI TWEEN 80 DAN SPAN 80 Sugita, Purwantiningsih; Napthaleni, Napthaleni; Kurniati, Mersi; Wukirsari, Tuti
Makara Journal of Science Vol. 14, No. 2
Publisher : UI Scholars Hub

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Abstract

Encapsulated Ketoprofen by Chitosan-Alginat based on Type and Variation of Tween 80 and Span 80 Concentration. Ketoprofen has been encapsulated by chitosan-alginate based on types of surfactant and it’s concentration. The variations of concentration either Tween 80 (polietilena sorbitanmonooleat) or Span 80 (sorbitanmonooleat) that used were around (1- 3)% concentrations with stirring around (15-60) minutes. The using of Tween 80 resulted efficiency of encapsulated ketoprofen and nano particle size (100-1000) nm are higher than Span 80.
Comparison of the Lipoamide Synthesis by Direct Amidation and via Amidation of Fatty Acid Methyl Esters Chiko Harahap; Tuti Wukirsari; Sri Handayani; Sumi Hudiyono PWS
Jurnal Kimia Sains dan Aplikasi Vol 27, No 7 (2024): Volume 27 Issue 7 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.7.328-335

Abstract

In this research, the preparation of lipoamide through direct amidation of fatty acid and via amidation of fatty acid methyl ester (FAME) was compared. The reactivity of aromatic amines and cyclohexylamine for the synthesis of lipoamide was investigated in this research. The performance of saturated and unsaturated fatty acids was also compared. The synthesis of lipoamides via direct amidation was conducted under reflux using a Dean-Stark trap and silica gel as the catalyst. On the other hand, the amidation of FAME was carried out without catalysts and solvent. Both reactions were run simultaneously for 18 hours at the same temperature. The reaction was monitored using TLC, and then the product was purified using column chromatography and characterized using FTIR and 1H NMR. The TLC data, FTIR, and 1H NMR spectra confirmed that both reaction pathways produced the same lipoamide as the product. Both reaction pathways were compatible with aromatic and nonaromatic amines and saturated and unsaturated fatty acids. The reaction yield of lipoamide from direct amidation was around 70-80% and two-fold higher than lipoamide synthesis via amidation of FAME. Therefore, direct amidation of fatty acid was preferred for the synthesis of lipoamides compared to via amidation of FAME.
Utilization of Silica Gel for the Synthesis of Geranyl Laurate and Citronellyl Laurate Rosalina, Khoerunissa Novianti; Wukirsari, Tuti; Handayani, Sri; Hudiyono, Sumi
Bulletin of Chemical Reaction Engineering & Catalysis 2024: BCREC Volume 19 Issue 2 Year 2024 (August 2024)
Publisher : Masyarakat Katalis Indonesia - Indonesian Catalyst Society (MKICS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.9767/bcrec.20159

Abstract

Geraniol and citronellol are monoterpenoid alcohols with diverse pharmacological activities. This research focuses on synthesized of geranyl laurate and citronellyl laurate using silica gel as an esterification catalyst. The FTIR peak spectra of silica gel showed that Si-OH, Si-O-Si group were observed. XRD showed that the silica gel is an amorphous phase. The reaction was conducted under reflux using a Dean–Stark trap. The reaction was monitored by TLC and then the product was purified using column chromatography. This work reported that silica gel can be utilized as a catalyst for preparing geranyl laurate and citronellyl laurate which proven by the spectra of FTIR, 1H-NMR, and 13C-NMR of the geranyl laurate and citronellyl laurate formed. The IR spectra of geranyl laurate and citronellyl laurate showed the presence of a carbonyl group (C=O) at 1744-1745 cm-1 and C-O from ester at 1170-1176 cm-1. The peak number and its chemical shift on 1H-NMR and 13C-NMR spectra further verified the structure of geranyl laurate and citronelyl laurate. In conclusion, silica gel can be utilized as a catalyst for preparing geranyl laurat and citronellyl laurate. Therefore a silica gel-based catalyst is promising to be developed for esterification applications.
Co-Authors Annisa Mawaddah Budi Arifin Chiko Harahap Endang Saepuddin Endang Saepudin Handayani, Sri Ivanka Putri Hanafiah Mersi Kurniati Napthaleni , Napthaleni, Napthaleni Purwantiningsih Sugita Rini Siswati Asnel Rosalina, Khoerunissa Novianti Sri Handayani Sumi Hudiyono Sumi Hudiyono PWS