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All Journal JURNAL PESISIR DAN LAUT TROPIS
Robert A Bara
FPIK UNSRAT
Earth & Planetary Sciences

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TOKSISITAS EKSTRAK KARANG LUNAK Cespitularia sp. DARI TELUK MANADO PROVINSI SULAWESI UTARA Marsitasari Tandiongan; Robert A Bara
JURNAL PESISIR DAN LAUT TROPIS Vol. 9 No. 3 (2021): JURNAL PESISIR DAN LAUT TROPIS
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35800/jplt.9.3.2021.36452

Abstract

Secondary metabolites produced by marine organisms commonly have unique chemical structures and very interesting pharmacological activities. Marine organisms that have the most chemical conent are produced by marine invertebrates, followed by marine plants. Groups that include marine invertebrates include: sponges, bryozoans, cnidarians and tunicates. Soft coral, which is one of the marine invertebrates, has biological activities, such as antifungal, cytotoxic, antineoplastic, antimicrobial, HIV inhibitor and anti-inflammatory. This study aims to determine the  value of the soft coral extract Cespitularia sp. taken from Manado Bay by the Brine Shrimp Lethality Assay (BSLA) method. This toxicity test was carried out quantitatively by analyzing data based on the number of deaths caused by the test extract of Artemia sp. The results obtained based on data analysis namely the value of the soft coral extract Cespitularia sp. is 53.27 ppm, this means that the extract can be developed as an anticancer drug candidate due to below below to 1000 ppm. Soft coral Cespitularia sp. categorized as toxic based on the Meyer classification or moderately toxic based on the Tanamatayarat classification and very toxic based on the Clarkson classification.Keywords: Soft coral; Cespitularia sp.; Toxicity;
AKTIVITAS SITOTOKSIK EKSTRAK KARANG LUNAK Xenia sp. DARI TELUK MANADO, PROVINSI SULAWESI UTARA Juniarti S Datula’bi; Robert A Bara; Fitje Losung; Remy EP Mangindaan; Ping A Angmalisang; Rose OSE Mantiri
JURNAL PESISIR DAN LAUT TROPIS Vol. 9 No. 3 (2021): JURNAL PESISIR DAN LAUT TROPIS
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35800/jplt.9.3.2021.36523

Abstract

Bioactive compounds from the sea which are generally in the form of secondary metabolites have the potential to be developed as medicinal ingredients. Marine life can be used as an object of research and development, considering the many benefits that can be taken from the secondary metabolite compounds contained in it, especially compounds that have bioactivity. Soft corals are marine biota that have bioactivity, extracts from sost coral contain bioactive compounds that have cytotoxic, anti-tumor, anti-viral, anti-inflammatory, anti-fungal, anti-leukemic, and enzyme activity inhibitory properties. Some of the research results show that marine soft corals have a variety of structures and biological activities including antioxidant substances. Soft corals were extracted by maceration method and then evaporated. The cytotoxic activity of soft coral extract was tested using the BLSA method and then analyzed the data to find the concentration of mortality (LC50). The purpose of this study was to test the cytotoxic activity of soft coral Xenia sp. The results of this study were testing the cytotoxic activity of the sample Xenia sp., amounting to 20.89 ppm, and having strong toxic properties. Key words: BLSA, Soft coral Xenia sp., LC50, Cytotoxic
Co-Authors Fitje Losung Juniarti S Datula’bi Marsitasari Tandiongan Ping A Angmalisang Remy EP Mangindaan Rose OSE Mantiri