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All Journal JURNAL PESISIR DAN LAUT TROPIS
Fitje Losung
FPIK UNSRAT
Earth & Planetary Sciences

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AKTIVITAS SITOTOKSIK EKSTRAK KARANG LUNAK Xenia sp. DARI TELUK MANADO, PROVINSI SULAWESI UTARA Juniarti S Datula’bi; Robert A Bara; Fitje Losung; Remy EP Mangindaan; Ping A Angmalisang; Rose OSE Mantiri
JURNAL PESISIR DAN LAUT TROPIS Vol. 9 No. 3 (2021): JURNAL PESISIR DAN LAUT TROPIS
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35800/jplt.9.3.2021.36523

Abstract

Bioactive compounds from the sea which are generally in the form of secondary metabolites have the potential to be developed as medicinal ingredients. Marine life can be used as an object of research and development, considering the many benefits that can be taken from the secondary metabolite compounds contained in it, especially compounds that have bioactivity. Soft corals are marine biota that have bioactivity, extracts from sost coral contain bioactive compounds that have cytotoxic, anti-tumor, anti-viral, anti-inflammatory, anti-fungal, anti-leukemic, and enzyme activity inhibitory properties. Some of the research results show that marine soft corals have a variety of structures and biological activities including antioxidant substances. Soft corals were extracted by maceration method and then evaporated. The cytotoxic activity of soft coral extract was tested using the BLSA method and then analyzed the data to find the concentration of mortality (LC50). The purpose of this study was to test the cytotoxic activity of soft coral Xenia sp. The results of this study were testing the cytotoxic activity of the sample Xenia sp., amounting to 20.89 ppm, and having strong toxic properties. Key words: BLSA, Soft coral Xenia sp., LC50, Cytotoxic
POTENSI BIOAKTIVITAS ANTI JAMUR DAN ANTI-UV DARI ISOLAT JAMUR SIMBION PADA ASCIDIA Eudistoma sp Enjelika Polimba Sahuma; Deiske A Sumilat; Veibe Warow; Fitje Losung; Esther D Angkouw; Okstan Kalesaran
JURNAL PESISIR DAN LAUT TROPIS Vol. 9 No. 3 (2021): JURNAL PESISIR DAN LAUT TROPIS
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35800/jplt.9.3.2021.36661

Abstract

Ascidia Eudistoma sp. produce bioactive compounds that can inhibit the growth of microorganisms. Ascidians are also known for their potential secondary metabolites in the biomedical world. This study aimed to obtain isolates of the ascidia symbiont Eudistoma sp., determine the antifungal activity against the test fungus Candida albicans, and determine the anti-UV activity of the symbiont Eudistoma sp. The ascidia symbiont fungus was extracted using maceration method with ethyl acetate solvent and tested for antifungal activity using the test fungus Candida albicans. The antifungal activity test results showed that the diameter of the AFBN 5b inhibition zone of 9 mm. The symbiont fungus can be said to have potential as an antifungal drug.  Testing the anti-UV activity of fungi in symbiosis with ascidia Eudistoma sp. using a spectrophotometer showed that the extract sample of the ascida symbiont fungus could produce an absorption at UV-B (λ 290–320 nm) of 3.8 absorbance and when compared to UV-A (λ 370–400 nm) an absorption value of 0.38 was obtained and is still classified as moderate Keywords: Ascidia, Eudistoma sp., symbionts, Antifungal and Anti-UV
Co-Authors Deiske A Sumilat Enjelika Polimba Sahuma Esther D Angkouw Juniarti S Datula’bi Okstan Kalesaran Ping A Angmalisang Remy EP Mangindaan Robert A Bara Rose OSE Mantiri Veibe Warow