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All Journal INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY KAIBON ABHINAYA : JURNAL PENGABDIAN MASYARAKAT
Nicko Pisceski Kusika Saputra
Universitas Riau
Humanities Economics, Econometrics & Finance Health Professions Social Sciences

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Penyuluhan Dan Pemeriksaan Sindrom Ovarium Polikistik Pada Remaja Di Pesantren An Nizam Minas Nicko Pisceski Kusika Saputra; Munawar Adhar Lubis
KAIBON ABHINAYA : JURNAL PENGABDIAN MASYARAKAT Vol. 6 No. 2 (2024)
Publisher : Universitas Serang Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30656/ka.v6i2.7670

Abstract

Polycystic ovary syndrome (PCOS) is a complex condition characterized by increased androgen levels, menstrual irregularities, and/or the presence of small cysts in one or both ovaries. The incidence of PCOS increases every year, including in Riau Province. Therefore, this service is carried out on teenagers, namely female students at the An Nizam Minas Islamic Boarding School, Siak Regency, to see the picture of PCOS in teenagers so that they can change their behavior and attitudes regarding eating patterns and better lifestyles so that it does not interfere with fertility in teenagers if they are diagnosed with PCOS. We intend to provide education regarding PCOS to teenagers and carry out ultrasound examinations on students who are suspected of having PCOS. The indicator of the success of this activity is that there is an increase in students' knowledge regarding PCOS through analysis of pretest and posttest results. Through this activity, publications will be produced in national journals, mass media publications and intellectual property rights. We show that there is an increase in the level of respondents' knowledge about PCOS between before and after the activity.
Vitamin D enhances migration but decreases gene expression of vascular endothelial growth factor and tumor necrosis factor-α in Wharton’s jelly mesenchymal stem cells Vitriyanna Mutiara Yuhendri; Nurfi Pratiwi; Ariza Julia Paulina; Ismawati Ismawati; Nicko Pisceski Kusika Saputra; Arfianti Arfianti
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 1 (2025): Advances in Biomarkers, Therapeutics, and Probiotics: Recent Updates in Medical L
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i1.6698

Abstract

Mesenchymal stem cells (MSCs) have gained significant interest for their potential application in repairing damaged tissues through immunomodulatory functions. Vitamin D has been shown to regulate both the innate and adaptive immune systems. Active forms of Vitamin D, such as 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are known to influence the action of mesenchymal stem cells (MSCs) in several mechanisms, such as stimulating their proliferation and osteogenic differentiation, as well as tissue regeneration. This study aimed to investigate the effects of vitamin D supplementation on the biological properties and expression of cytokines and growth factor genes in MSCs isolated from the human umbilical cord (UC). MSCs were isolated from Wharton’s jelly (WJ-MSC) of UC, cultured, and supplemented with various concentrations of vitamin D3. The Cell Counting Kit-8 (CCK-8) assay was used to measure cell viability, and a scratch wound healing assay was conducted to evaluate the migration capacity of MSCs. The mRNA expression levels of vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 were quantified using reverse transcription-polymerase chain reaction (RT-PCR). This study showed that supplementation with 50 nM of vitamin D3 for 48 h significantly increased the viability and migratory capacity of MSCs. Furthermore, vitamin D supplementation significantly decreased the mRNA levels of TNF-α and VEGF but did not affect IL-6 gene expression compared to the control group. These findings suggest that vitamin D supplementation can enhance the biological characteristics and modulate the expression of key immunomodulatory factors in MSCs, potentially improving the effectiveness of MSC-based therapies.
Co-Authors Arfianti Arfianti Ariza Julia Paulina Ismawati ismawati Munawar Adhar Lubis Nurfi Pratiwi Vitriyanna Mutiara Yuhendri