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All Journal Acta Biochimica Indonesiana Society: Jurnal Pengabdian Masyarakat Indonesian Community Journal Molekul: Jurnal Ilmiah Kimia
Taufiq, Hameda Dhaka Kusuma
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Public Health Social Sciences Other

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Detoxification of Cadmium on Albino Rats (Rattus norvegicus) with Natural Chelator of Fruiting Body Extract of Ganoderma lucidum Hameda Dhaka Kusuma Taufiq; Hernayanti Hernayanti; Nuniek Ina Ratnaningtyas
Molekul Vol 18 No 1 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.1.5844

Abstract

Cadmium is a heavy metal pollutant sourced from various industries and toxic to the kidneys. Cadmium exposure can be used natural chelator of ethanol extract of the fruiting body of Ganoderma lucidum. The aim of the study was to determine the effect and effective dose of the ethanolic extract of the fruiting body of G. lucidum on reducing the toxicity effect of cadmium in male albino rats (Rattus norvegicus) Wistar strain. The research design was experimental research, which consisted of 5 treatment levels. The research parameters were blood cadmium, β2-microglobulin, malondialdehyde, and superoxide dismutase levels. The ethanolic extract of fruiting body of G. lucidum was tested by gas chromatography-mass spectrometry (GCMS) to determine linalool as active compounds. The results of each parameter had a significant effect, which decreased blood cadmium, β2M and MDA levels, and increased SOD level that linear according to the addition of the dose of ethanol extract of the fruiting body of G. lucidum. Blood cadmium levels with β2M and MDA levels had a positive correlation, while blood cadmium levels with SOD levels had a negative correlation. The dominant compound detected was linalool which has potential as a radical scavenger. The dose of 750 mg.kgBW-1 is the effective dose of the ethanolic extract of fruiting body of G. lucidum based on a decrease in blood cadmium levels (54.10%), β2M (63.94%) and MDA (20.31%), as well as an increase in SOD levels (14.20%) compared to sick control.
Meningkatkan Kesadaran Masyarakat Tentang Aedes aegypti di Era Cuaca Ekstrem Endris, Wahyu Maulana; Ali, Musyafa; Taufiq, Hameda Dhaka Kusuma; Wasito, Wasito
Society : Jurnal Pengabdian Masyarakat Vol 3, No 1 (2024): Januari
Publisher : Edumedia Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55824/jpm.v3i1.380

Abstract

This community service the impact of community engagement activities on public knowledge regarding dengue fever and its prevention methods. Through pre- and post-tests conducted with 120 participants, a significant improvement in knowledge is observed after their participation in these activities. Previously, the majority of participants had limited knowledge, but after the intervention, approximately 80% of them demonstrated a better understanding. This success is not only reflected in the increased knowledge scores but also in the high level of participation, indicating the community's enthusiasm for supporting these awareness initiatives. The findings affirm the effectiveness of community engagement approaches in enhancing public knowledge and provide impetus for similar initiatives in the future. This achievement is pivotal in strengthening public awareness about health and disease prevention, laying a robust foundation for sustained community-level preventive efforts
Sosialisasi Pengenalan Siklus Aedes aegypti untuk Meningkatkan Kesadaran Pencegahan Demam Berdarah Dengue pada Siswa SDN 1 Sungai Besar Banjarbaru Muhamat, Muhamat; Gafur, Abdul; Rakmawati, Rakmawati; Anitasari, Lucia Desti; Taufiq, Hameda Dhaka Kusuma; Maulidiyah, Hikmah
I-Com: Indonesian Community Journal Vol 5 No 3 (2025): I-Com: Indonesian Community Journal (September 2025)
Publisher : Fakultas Sains Dan Teknologi, Universitas Raden Rahmat Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70609/i-com.v5i3.7698

Abstract

The Aedes aegypti mosquito is a vector for transmitting the dengue virus, which causes dengue hemorrhagic fever (DHF). This community service program was carried out by providing outreach and mentoring regarding the bioecology of Ae. aegypti to students of SDN 1 Sungai Besar, Banjarbaru. The limited knowledge of the school community, especially the students of SDN 1 Sungai Besar, about vector mosquitoes and their bioecology makes them less concerned about the environment. Systematic knowledge about DHF must be implemented from an early age to help raise awareness of the importance of sanitation in preventing the home and school environment from becoming mosquito habitats. Pre-test and post-test questionnaires were used to measure students' understanding of the bioecology of Ae. aegypti mosquitoes and were given to 25 students. Based on data analysis, it can be concluded that the outreach and mentoring program is effective and can help increase students' knowledge of the importance of sanitation in preventing the home and school environment from becoming mosquito habitats. This activity needs to be carried out in schools in Banjarbaru City so that the school environment does not become a habitat for Ae. aegypti mosquitoes.
Meningkatkan Kesadaran Masyarakat Tentang Aedes aegypti di Era Cuaca Ekstrem Endris, Wahyu Maulana; Ali, Musyafa; Taufiq, Hameda Dhaka Kusuma; Wasito, Wasito
Society : Jurnal Pengabdian Masyarakat Vol. 3 No. 1 (2024): Januari
Publisher : Edumedia Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55824/jpm.v3i1.380

Abstract

This community service the impact of community engagement activities on public knowledge regarding dengue fever and its prevention methods. Through pre- and post-tests conducted with 120 participants, a significant improvement in knowledge is observed after their participation in these activities. Previously, the majority of participants had limited knowledge, but after the intervention, approximately 80% of them demonstrated a better understanding. This success is not only reflected in the increased knowledge scores but also in the high level of participation, indicating the community's enthusiasm for supporting these awareness initiatives. The findings affirm the effectiveness of community engagement approaches in enhancing public knowledge and provide impetus for similar initiatives in the future. This achievement is pivotal in strengthening public awareness about health and disease prevention, laying a robust foundation for sustained community-level preventive efforts
Nephroprotective effects of ethanolic extract of Ganoderma lucidum against diethylene glycol-induced acute kidney injury in rats Hernayanti; Taufiq, Hameda Dhaka Kusuma
Acta Biochimica Indonesiana Vol. 8 No. 2 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.195

Abstract

Background: Diethylene glycol (DEG) contamination in pharmaceutical preparations has caused numerous cases of acute kidney injury, particularly in pediatric populations. Current treatments are expensive and not readily accessible in resource-limited settings. Ganoderma lucidum, a medicinal mushroom rich in triterpenoids, flavonoids, and ergothioneine, may offer a natural therapeutic alternative. Objective: This study evaluated the nephroprotective potential of ethanolic G. lucidum extract against DEG-induced acute kidney injury in rats. Methods: Twenty-four male Wistar rats were divided into six groups: healthy control, DEG-induced control (5 g/kg BW), three G. lucidum treatment groups (250, 500, 750 mg/kg BW for 7 days plus DEG), and fomepizole control (5 mg/kg BW plus DEG). Renal function markers (β2-microglobulin, malondialdehyde) and electrolytes (sodium, potassium, chloride) were measured on day 11. Results: DEG significantly elevated β2-microglobulin (0.73 vs. 0.29 ng/mL) and malondialdehyde levels (3.368 vs. 0.72 μmol/L) while reducing electrolytes. G. lucidum extract at 500 and 750 mg/kg BW significantly improved all parameters, achieving efficacy comparable to fomepizole (p > 0.05). Conclusion: Ethanolic G. lucidum extract demonstrates significant nephroprotective effects against DEG-induced kidney injury, with 500 mg/kg BW as the optimal therapeutic dose.
Co-Authors Abd. Gafur Ali, Musyafa Anitasari, Lucia Desti Endris, Wahyu Maulana Hernayanti HERNAYANTI HERNAYANTI Maulidiyah, Hikmah Muhamat Muhamat Nuniek Ina Ratnaningtyas Rakmawati, Rakmawati Wasito Wasito