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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research
Zaki Mahmudi Dasril
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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Pregnancy-Triggered Severe Lupus Nephritis with Pleural Effusion: A Case Report Zaki Mahmudi Dasril; Deka Viotra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1275

Abstract

Background: Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE), characterized by kidney inflammation. Pregnancy can trigger or exacerbate LN due to hormonal shifts and altered immune responses. This case highlights the challenges in diagnosing and managing pregnancy-associated LN. Case presentation: A 27-year-old woman presented with anasarca, malar rash, shortness of breath, and foamy urine during her first pregnancy. She had a history of SLE with previous symptoms limited to skin and joint involvement. Investigations revealed nephrotic-range proteinuria, hematuria, elevated creatinine, and positive anti-nuclear antibodies (ANA). Renal biopsy confirmed Class IV lupus nephritis. She was diagnosed with pregnancy-triggered severe LN with nephrotic syndrome, pleural effusion, and a hypercoagulable state. Treatment included high-dose corticosteroids and mycophenolate mofetil, with close monitoring of both maternal and fetal health. Conclusion: This case underscores the importance of recognizing and promptly managing LN in pregnancy. Early diagnosis, multidisciplinary care, and individualized treatment are crucial to optimize maternal and fetal outcomes.
Virological and Clinical Studies of Viral Hemorrhagic Fever (VHF): A Systematic Literature Review Fadrian; Armen Ahmad; Zaki Mahmudi Dasril
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1065

Abstract

Background: Viral hemorrhagic fever (VHF) is a group of zoonotic diseases caused by various RNA viruses, such as Ebola, Marburg, Lassa, Crimean-Congo hemorrhagic fever (CCHF), and Dengue. VHF poses a serious threat to global public health due to high morbidity and mortality rates. This study aims to conduct a systematic literature review of virological and clinical studies of VHF to understand the characteristics of the virus, pathogenesis, clinical manifestations, risk factors, diagnosis, and current therapeutic options. Methods: A comprehensive literature search was conducted on PubMed, Scopus, and Web of Science databases to identify relevant studies published between 2018 and 2024. Studies that met the inclusion criteria were evaluated for quality and narratively synthesized. Results: This review included 20 studies involving 2,350 VHF patients. Results demonstrated significant diversity in virologic characteristics, pathogenesis, and clinical manifestations among different types of VHF. These studies also highlight advances in molecular and serological diagnosis, as well as the development of antiviral and immunomodulatory therapies. Conclusion: This systematic literature review provides a comprehensive summary of current knowledge regarding the virology and clinical practice of VHF. These findings may guide the development of more effective prevention, diagnosis, and treatment strategies for this life-threatening disease.
Co-Authors Abdul Alim Rahimi Alexander Kam Armen Ahmad Deka Viotra Drajad Priyono Fadrian, Fadrian Fauzar Harun Harnavi Jersivindo Ranazeri Roza Kurniati