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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Pengabdian Masyarakat: Humanity and Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research
Wirdah, Aisyah
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Penerapan respiratory fit test pada kader tuberkulosis dalam pencegahan penularan tuberkulosis di Palembang Pasaribu, Rouly; Fathurrachman, Alif; Wirdah, Aisyah; Andriani, Linda; Sudarto, Sudarto; Rasyid, Ahmad; Ahmad, Zen
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 5 No 3 (2024): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V5I3.145

Abstract

According to the 2023 world tuberculosis (TB) report, Indonesia ranks 2nd in the world with an estimated 1,060,000 cases. Transmission of TB germs through droplets that enter the airways. TB cadres play an important role in assisting TB patients undergoing treatment, especially drug-resistant TB. TB cadres also play a role in providing health information to TB patients to achieve optimal treatment and achieve treatment success. During their roles, TB cadres who are in contact with active pulmonary TB patients are very vulnerable to infection. The implementation of respiratory fit tests for TB cadres in Palembang is needed, so that TB cadres in Palembang do not contract TB germs. Through the TB cadre organization, namely the Sriwijaya Healthy Society, 15 TB cadres were given counseling on the proper use of respirators and in accordance with conducting a fit test first. Through individual simulations with respirator fit tests, appropriate application was obtained for all TB cadres in using appropriate respirators. Through this activity, it is hoped that TB cadres in the city of Palembang will be able to carry out their duties safely and comfortably.
Effectiveness of Nigella sativa Addition against TNF-Alpha in Stage III and IV Breast Cancer Undergoing Doxorubicin and Cyclophosphamide Chemotherapy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Friyoga Syahril; Wirdah, Aisyah; Nur Qodir; Irfanuddin; Irsan Saleh; Yenny Dian Andayani; Mediarty; Norman Djamaluddin
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 2 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i2.924

Abstract

Background: Breast cancer is a malignancy caused by the continuous uncontrolled growth of the component cells of the ducts or lobules of the breast gland. Globally, breast cancer is the second leading cause of death in women. Nigella sativa contains substances thymoquinone. Thymoquinone can inhibit the progression of cancer through anti-inflammatory, anti-oxidant mechanisms, inhibit proliferation, trigger apoptosis, and prevent angiogenesis. Chronic inflammation in breast cancer is mediated by one of them is TNF-alpha tumors. Elevated levels of TNF-α have a significant association with poor prognosis and progression of breast cancer. This study aims to determine the effectiveness of the additional Nigella sativa in declining TNF-α levels in breast cancer patients at Dr. Mohammad Hoesin General Hospital Palembang. Methods: This research used a randomized, open clinical trial design, which was carried out at the internal medicine hematology-oncology medical polyclinic and the surgical oncology polyclinic of Dr. Mohammad Hoesin General Hospital Palembang from January 2023 to October 2023. Data processing for data analysis used SPSS version 26 for Windows. Results: There were 36 research subjects followed during the study period and received Doxorubicin chemotherapy and cyclophosphamide (AC), which were divided into treatment groups of 18 people (chemotherapy with the addition of Nigella sativa @600 mg 2x2 capsule/ day and a control group of 18 people. A TNF-alpha examination was carried out before and after to assess the comparison before and after. From the results, it was found that TNF-alpha levels in the treatment group showed a decrease in TNF-alpha with a p-value <0.001. Conclusion: The addition of Nigella sativa has the effect of reducing TNF-alpha in breast cancer patients receiving AC chemotherapy at Dr. Mohammad Hoesin General Hospital, Palembang.
Effectiveness of Nigella sativa Addition against TNF-Alpha in Stage III and IV Breast Cancer Undergoing Doxorubicin and Cyclophosphamide Chemotherapy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Friyoga Syahril; Wirdah, Aisyah; Nur Qodir; Irfanuddin; Irsan Saleh; Yenny Dian Andayani; Mediarty; Norman Djamaluddin
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 2 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i2.924

Abstract

Background: Breast cancer is a malignancy caused by the continuous uncontrolled growth of the component cells of the ducts or lobules of the breast gland. Globally, breast cancer is the second leading cause of death in women. Nigella sativa contains substances thymoquinone. Thymoquinone can inhibit the progression of cancer through anti-inflammatory, anti-oxidant mechanisms, inhibit proliferation, trigger apoptosis, and prevent angiogenesis. Chronic inflammation in breast cancer is mediated by one of them is TNF-alpha tumors. Elevated levels of TNF-α have a significant association with poor prognosis and progression of breast cancer. This study aims to determine the effectiveness of the additional Nigella sativa in declining TNF-α levels in breast cancer patients at Dr. Mohammad Hoesin General Hospital Palembang. Methods: This research used a randomized, open clinical trial design, which was carried out at the internal medicine hematology-oncology medical polyclinic and the surgical oncology polyclinic of Dr. Mohammad Hoesin General Hospital Palembang from January 2023 to October 2023. Data processing for data analysis used SPSS version 26 for Windows. Results: There were 36 research subjects followed during the study period and received Doxorubicin chemotherapy and cyclophosphamide (AC), which were divided into treatment groups of 18 people (chemotherapy with the addition of Nigella sativa @600 mg 2x2 capsule/ day and a control group of 18 people. A TNF-alpha examination was carried out before and after to assess the comparison before and after. From the results, it was found that TNF-alpha levels in the treatment group showed a decrease in TNF-alpha with a p-value <0.001. Conclusion: The addition of Nigella sativa has the effect of reducing TNF-alpha in breast cancer patients receiving AC chemotherapy at Dr. Mohammad Hoesin General Hospital, Palembang.
Co-Authors ahmad rasyid, ahmad Ahmad, Zen Andriani, Linda Fathurrachman, Alif Friyoga Syahril Irfanuddin Irsan Saleh Mediarty Norman Djamaluddin Nur Qodir Pasaribu, Rouly Sudarto Sudarto Yenny Dian Andayani