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The Significance of TGF-β Expression in Predicting Lymphovascular Invasion and Lymph Node Metastasis in Colorectal Cancer Aini, Julpa Nurul; Aswiyanti Asri; Noza Hilbertina; Tofrizal; Avit Suchitra; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1182

Background: Colorectal cancer (CRC) is a major health burden globally. The prognosis of CRC is strongly influenced by the presence of lymphovascular invasion (LVI) and lymph node (LN) metastasis. Transforming growth factor-beta (TGF-β) is a cytokine with a complex role in CRC progression. This study aimed to evaluate the significance of TGF-β expression in predicting LVI and LN metastasis in CRC. Methods: This cross-sectional study involved 50 patients diagnosed with CRC. The expression of TGF-β was assessed using immunohistochemical staining and the Allred scoring system. The relationship between TGF-β expression and the presence of LVI and LN metastasis was analyzed using the Chi-square test. Results: High TGF-β expression was significantly associated with both LVI (p = 0.011) and LN metastasis (p = 0.012) in CRC. Patients with high TGF-β expression had a higher risk of LVI and LN metastasis compared to those with low TGF-β expression. Conclusion: TGF-β expression is a significant predictor of LVI and LN metastasis in CRC. This finding has potential implications for risk stratification and treatment decisions in CRC patients.

Mycosis Fungoides dengan Gambaran Klinis Eritroderma yang Menyerupai Dermatitis Seboroik Tofrizal; Mayorita, Pamelia; Aini, Julpa Nurul; Nelzima, Maisyah; Oktora, Meta Zulyati
Scientific Journal Vol. 4 No. 2 (2025): SCIENA Volume IV No 2, March 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i2.200

Mycosis fungoides (MF) merupakan limfoma T-sel kulit primer yang paling sering ditemukan, termasuk dalam kategori Cutaneous T-cell Lymphomas (CTCL). MF ditandai dengan proliferasi sel T epidermotropik yang sebagian besar terdiri dari sel CD4+. Penyakit ini memiliki perjalanan klinis yang umumnya lambat, diawali dengan lesi berupa patch atau plak eritematosa yang secara bertahap dapat berkembang menjadi tumor atau eritroderma pada stadium lanjut. Eritroderma, yang melibatkan lebih dari 80% permukaan kulit, sering kali sulit dibedakan dari dermatitis inflamasi lainnya, seperti dermatitis seboroik, psoriasis, atau penyakit sistemik lainnya. Oleh karena itu, pengenalan dini dan diagnosis akurat sangat penting untuk menentukan terapi yang tepat dan memperbaiki prognosis pasien. Laporan ini memaparkan kasus seorang pria berusia 53 tahun dengan gejala eritroderma yang awalnya menyerupai dermatitis seboroik. Pemeriksaan fisik dan laboratorium awal menunjukkan adanya lesi kulit meluas disertai skuama kasar, sehingga diduga eritroderma akibat Cutaneous T-cell Lymphoma (CTCL). Hasil biopsi eksisi kulit mengungkapkan infiltrasi sel limfosit atipikal yang menunjukkan epidermotropisme dan pembentukan Pautrier microabscesses, yang mengarah pada diagnosis MF. Pemeriksaan imunohistokimia menunjukkan hasil positif untuk CD3 dan CD4, yang semakin memperkuat diagnosis tersebut. Pasien direncanakan menjalani kemoterapi sebanyak enam siklus, namun pada saat akan menjalani kemoterapi siklus ketiga, kondisi pasien memburuk dengan penurunan kesadaran akibat hiponatremia dan komplikasi lain, hingga akhirnya meninggal dunia. Diagnosis MF pada tahap awal sering kali menjadi tantangan karena manifestasi klinisnya yang menyerupai penyakit kulit inflamasi lainnya. Oleh karena itu, kombinasi pemeriksaan klinis, histopatologi, dan imunohistokimia sangat diperlukan untuk membedakan MF dari diagnosis banding lainnya. Penatalaksanaan yang tepat dan pemantauan jangka panjang menjadi kunci dalam memperbaiki prognosis pasien, terutama pada stadium lanjut MF yang memerlukan terapi sistemik agresif.

Collecting Duct Carcinoma in the Kidneys: A Rare Case Report Aini, Julpa Nurul; Noza Hilbertina; Pamelia Mayorita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 7 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i7.1023

Background: Collecting duct carcinoma (CDC) is one of the rare pathological subtypes of renal cell carcinoma, with high malignancy and poor prognosis. Pathological examination is the gold standard in confirming the diagnosis of CDC. CDC is described as a tumor that has a tubulopapillary architecture and forms a hobnail pattern along the glandular tube. Case presentation: A 56-year-old woman with the main complaint of a lump in the right abdomen for 1.5 months before entering the hospital. The lump in the stomach is getting bigger, complaints are accompanied by intermittent pain, nausea, vomiting, body feeling weak, and decreased appetite. The patient then underwent a CT-Scan examination of the abdomen and concluded that fluid/water was found next to the right kidney, and a hypodense lesion appeared in segment 6 of the right lobe of the liver. Histopathological examination of large tissue shows pieces of kidney tissue with a connective tissue capsule on the outside containing glomeruli and tubules lined by cuboidal epithelium as well as a proliferation of tumor cells that grow infiltratively in the connective tissue stroma which is partly desmoplastic and fatty tissue between the glomeruli and tubules. Tumor cells are arranged to form tubulopapillary and tubulocystic structures. These cells with pleomorphic nuclei, some hyperchromatic, some vesicular, coarse chromatin, clear nuclei, and atypical mitoses can be found and tumor cell embolism in the blood vessels and perineural invasion can be seen. There were spots and clusters of lymphocytes and plasma cells as well as areas of bleeding and necrosis. Conclusion: The patient was diagnosed with collecting duct carcinoma (CDC).

Collecting Duct Carcinoma in the Kidneys: A Rare Case Report Aini, Julpa Nurul; Noza Hilbertina; Pamelia Mayorita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 7 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i7.1023

Background: Collecting duct carcinoma (CDC) is one of the rare pathological subtypes of renal cell carcinoma, with high malignancy and poor prognosis. Pathological examination is the gold standard in confirming the diagnosis of CDC. CDC is described as a tumor that has a tubulopapillary architecture and forms a hobnail pattern along the glandular tube. Case presentation: A 56-year-old woman with the main complaint of a lump in the right abdomen for 1.5 months before entering the hospital. The lump in the stomach is getting bigger, complaints are accompanied by intermittent pain, nausea, vomiting, body feeling weak, and decreased appetite. The patient then underwent a CT-Scan examination of the abdomen and concluded that fluid/water was found next to the right kidney, and a hypodense lesion appeared in segment 6 of the right lobe of the liver. Histopathological examination of large tissue shows pieces of kidney tissue with a connective tissue capsule on the outside containing glomeruli and tubules lined by cuboidal epithelium as well as a proliferation of tumor cells that grow infiltratively in the connective tissue stroma which is partly desmoplastic and fatty tissue between the glomeruli and tubules. Tumor cells are arranged to form tubulopapillary and tubulocystic structures. These cells with pleomorphic nuclei, some hyperchromatic, some vesicular, coarse chromatin, clear nuclei, and atypical mitoses can be found and tumor cell embolism in the blood vessels and perineural invasion can be seen. There were spots and clusters of lymphocytes and plasma cells as well as areas of bleeding and necrosis. Conclusion: The patient was diagnosed with collecting duct carcinoma (CDC).

The Significance of TGF-β Expression in Predicting Lymphovascular Invasion and Lymph Node Metastasis in Colorectal Cancer Aini, Julpa Nurul; Aswiyanti Asri; Noza Hilbertina; Tofrizal; Avit Suchitra; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1182

Background: Colorectal cancer (CRC) is a major health burden globally. The prognosis of CRC is strongly influenced by the presence of lymphovascular invasion (LVI) and lymph node (LN) metastasis. Transforming growth factor-beta (TGF-β) is a cytokine with a complex role in CRC progression. This study aimed to evaluate the significance of TGF-β expression in predicting LVI and LN metastasis in CRC. Methods: This cross-sectional study involved 50 patients diagnosed with CRC. The expression of TGF-β was assessed using immunohistochemical staining and the Allred scoring system. The relationship between TGF-β expression and the presence of LVI and LN metastasis was analyzed using the Chi-square test. Results: High TGF-β expression was significantly associated with both LVI (p = 0.011) and LN metastasis (p = 0.012) in CRC. Patients with high TGF-β expression had a higher risk of LVI and LN metastasis compared to those with low TGF-β expression. Conclusion: TGF-β expression is a significant predictor of LVI and LN metastasis in CRC. This finding has potential implications for risk stratification and treatment decisions in CRC patients.

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