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Study of Analysis of Beta Human Chorionic Gonadotropin (hCG) Levels Before and After Hysterectomy in Gestational Trophoblastic Neoplasia (GTN) Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Wella Novile Izora; Rikarni; Dwi Yulia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1059

Background: Gestational trophoblastic neoplasia (GTN) is a malignant tumor originating from placental trophoblast which causes mortality due to bleeding. Trophoblast produces beta hormone human chorionic gonadotropin (hCG). Quantitative examination of serum beta hCG is used to support the diagnosis and management of GTN. Hysterectomy is performed in bleeding conditions as the main therapy besides chemotherapy. This study aims to analyze differences in beta hCG levels before and after hysterectomy in GTN patients at Dr. M. Djamil General Hospital Padang. Methods: Retrospective observational analytical research design cross-sectional from 21 samples of GTN patients for the period July 2021 to June 2023 at Dr. M. Djamil General Hospital Padang. Quantitative beta hCG level examination is carried out before and after the hysterectomy. The Shapiro-Wilk test was carried out for data normality and continued with the Wilcoxon nonparametric tests to find out significant differences in beta hCG levels. Results: The most common characteristics of GTN patients were age ≥35 years, namely 15 (71.4%) patients, multiparity in 14 (66.7%) patients, and indication for hysterectomy due to bleeding in 14 (66.7%) patients. The median beta hCG level before hysterectomy was 46,000 (117.10-653,874) mIU/mL and the median after hysterectomy was 113.3 (0.12-3,693) mIU/mL. Beta hCG levels after hysterectomy were found to be normal (<5 mIU/mL) in five patients (23.8%). There was a significant difference in beta hCG levels before and after hysterectomy (p <0.001). Conclusion: Beta hCG levels after hysterectomy decreased compared to before hysterectomy. Hysterectomy therapy is useful for reducing beta hCG levels in GTN patients.

Differences in Average Albumin Levels in Coronavirus Disease 2019 (COVID-19) Survivor and Non-Survivor Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Atrya, Doan; Rikarni; Elvira Yusri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1062

Background: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection triggers a systemic inflammatory response that can lead to a decrease in serum albumin levels. A more severe inflammatory response in non-survivor COVID-19 patients may correlate with a more significant decrease in albumin levels. This study aims to analyze differences in mean albumin levels in COVID-19 survivors and non-survivors. Methods: This cross-sectional analytical study involved 40 COVID-19 survivors and non-survivors treated at Dr. M. Djamil General Hospital Padang from July 2021 to September 2021. Serum albumin levels were checked using an automated clinical chemistry tool. Data analysis was carried out using the Mann-Whitney non-parametric test, with a significance level of p < 0.05. Results: The mean age of the study subjects was 49.4 (16.3) years, with the majority of cases occurring in men (67.5%). The median albumin levels in all COVID-19 patients, COVID-19 survivors, and COVID-19 non-survivors were 3.2 (2.20–5.00) g/dL, respectively; 4.1 (3.0–5.0) g/dL; and 2.9 (2.20–3.70) g/dL (p = 0.001). Conclusion: There is a significant difference in mean albumin levels between COVID-19 survivors and non-survivors. Lower albumin levels were found in non-survivor patients. Albumin can be a potential biomarker for predicting clinical outcomes of COVID-19 patients.

Study Analysis of Total Bilirubin Levels on Mortality in COVID-19 Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Suhardi, Suryo Nugroho; Rikarni; Dwi Yulia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1053

Background: Coronavirus Disease 2019 (COVID-19) is caused by a positive single-stranded RNA virus. The clinical manifestations of COVID-19 are not only dominated by respiratory tract symptoms but can also show symptoms of liver damage in severe COVID-19 patients. Liver damage that occurs can cause acute liver failure and result in death. Examination of liver damage marker parameters such as total bilirubin needs to be carried out as mortality increases in COVID-19 patients. This study aims to determine the relationship between total bilirubin levels and mortality in COVID-19 patients. Methods: Cross-sectional analytical research was conducted on 40 COVID-19 patients treated at Dr. M. Djamil General Hospital Padang from July to December 2021. Examination of total bilirubin levels using the colorimetric diazo method. Bivariate analysis used the Mann-Whitney test to see the relationship between total bilirubin levels and mortality. Results: The average age of the research subjects was 61.85 (1.40) years, with 65% men and 35% women. The mortality percentage in COVID-19 patients is 65%. The median total bilirubin level was 1.95 (0.5-2.8) mg/dL. The relationship between total bilirubin levels and mortality in COVID-19 patients was found to have a p-value of <0.001. The study results showed that the median total bilirubin level in COVID-19 patients who died was relatively higher, namely 2.20 (1.4-2.8) mg/dL, compared to those who did not die, namely 0.70 (0.5-1. 6) mg/dL. Conclusion: The results of this study show that there is a relationship between total bilirubin levels and mortality in COVID-19 patients.

Study of Analysis of Beta Human Chorionic Gonadotropin (hCG) Levels Before and After Hysterectomy in Gestational Trophoblastic Neoplasia (GTN) Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Wella Novile Izora; Rikarni; Dwi Yulia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1059

Background: Gestational trophoblastic neoplasia (GTN) is a malignant tumor originating from placental trophoblast which causes mortality due to bleeding. Trophoblast produces beta hormone human chorionic gonadotropin (hCG). Quantitative examination of serum beta hCG is used to support the diagnosis and management of GTN. Hysterectomy is performed in bleeding conditions as the main therapy besides chemotherapy. This study aims to analyze differences in beta hCG levels before and after hysterectomy in GTN patients at Dr. M. Djamil General Hospital Padang. Methods: Retrospective observational analytical research design cross-sectional from 21 samples of GTN patients for the period July 2021 to June 2023 at Dr. M. Djamil General Hospital Padang. Quantitative beta hCG level examination is carried out before and after the hysterectomy. The Shapiro-Wilk test was carried out for data normality and continued with the Wilcoxon nonparametric tests to find out significant differences in beta hCG levels. Results: The most common characteristics of GTN patients were age ≥35 years, namely 15 (71.4%) patients, multiparity in 14 (66.7%) patients, and indication for hysterectomy due to bleeding in 14 (66.7%) patients. The median beta hCG level before hysterectomy was 46,000 (117.10-653,874) mIU/mL and the median after hysterectomy was 113.3 (0.12-3,693) mIU/mL. Beta hCG levels after hysterectomy were found to be normal (<5 mIU/mL) in five patients (23.8%). There was a significant difference in beta hCG levels before and after hysterectomy (p <0.001). Conclusion: Beta hCG levels after hysterectomy decreased compared to before hysterectomy. Hysterectomy therapy is useful for reducing beta hCG levels in GTN patients.

Differences in Average Albumin Levels in Coronavirus Disease 2019 (COVID-19) Survivor and Non-Survivor Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Atrya, Doan; Rikarni; Elvira Yusri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1062

Background: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection triggers a systemic inflammatory response that can lead to a decrease in serum albumin levels. A more severe inflammatory response in non-survivor COVID-19 patients may correlate with a more significant decrease in albumin levels. This study aims to analyze differences in mean albumin levels in COVID-19 survivors and non-survivors. Methods: This cross-sectional analytical study involved 40 COVID-19 survivors and non-survivors treated at Dr. M. Djamil General Hospital Padang from July 2021 to September 2021. Serum albumin levels were checked using an automated clinical chemistry tool. Data analysis was carried out using the Mann-Whitney non-parametric test, with a significance level of p < 0.05. Results: The mean age of the study subjects was 49.4 (16.3) years, with the majority of cases occurring in men (67.5%). The median albumin levels in all COVID-19 patients, COVID-19 survivors, and COVID-19 non-survivors were 3.2 (2.20–5.00) g/dL, respectively; 4.1 (3.0–5.0) g/dL; and 2.9 (2.20–3.70) g/dL (p = 0.001). Conclusion: There is a significant difference in mean albumin levels between COVID-19 survivors and non-survivors. Lower albumin levels were found in non-survivor patients. Albumin can be a potential biomarker for predicting clinical outcomes of COVID-19 patients.

Hubungan Kadar Cancer Antigen 125 dan Metastasis pada Kanker Ovarium Tipe Epitel Wulandari, Natasya; Rikarni; Irramah, Miftah; Yaswir, Rismawati; Afriani, Nita
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 1 (2026): Maret 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i1.1332

Latar belakang: Kanker ovarium tipe epitel merupakan salah satu jenis dari kanker ovarium, dan merupakan tipe terbanyak (95%). Kanker ovarium menempati peringkat tujuh berdasarkan insiden dan mortalitas di dunia. Salah satu pemeriksaan preoperatif yang dapat dilakukan untuk kanker ovarium adalah pemeriksaan penanda tumor cancer antigen 125 (CA-125). Penelitian memperlihatkan bahwa kadar CA-125 yang tinggi berhubungan dengan metastasis kanker ovarium. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan kadar CA-125 dan metastasis pada kanker ovarium tipe epitel. Metode: Penelitian ini merupakan penelitian analitik observasional dengan desain cross sectional retrospektif dengan dengan teknik pengambilan sampel consecutive sampling. Sampel adalah pasien kanker ovarium tipe epitel yang bermetastasis sejumlah 15 orang dan tidak bermetastasis sejumlah 15 orang. Hasil: Usia pasien kanker ovarium tipe epitel terbanyak ditemukan pada kelompok usia 41-50 tahun yaitu 30%. Subtipe terbanyak adalah high grade serous yaitu 53,3%. Sebanyak 73,3% pasien memiliki kadar CA-125 ≥35 U/mL. Organ yang paling banyak mengalami metastasis adalah omentum yaitu 80%. Median kadar CA-125 pada kanker ovarium yang tidak bermetastasis lebih rendah (23,15 U/mL) dibanding yang bermetastasis (>600 U/mL). Hasil uji Chi-square menunjukkan hubungan yang signifikan antara kadar CA-125 dengan metastasis pada kanker ovarium tipe epitel (p=0,001). Kurva ROC menunjukkan nilai cut-off untuk metastasis adalah 139,59 U/mL dengan sensitivitas 93% dan spesifisitas 80%. Kesimpulan: Terdapat hubungan signifikan antara kadar CA-125 dengan metastasis pada kanker ovarium tipe epitel di RSUP Dr. M. Djamil Padang.

Hubungan Mekanisme Koping dengan Kualitas Hidup Pada Pasien Kanker Payudara yang Sedang Menjalani Kemoterapi Karina, Puti Intan; Yanis, Amel; Kurniawati, Yulia; Sauma, Eldi; Rikarni; Nofita, Eka
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 1 (2026): Maret 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i1.1538

Latar Belakang: Kemoterapi merupakan salah satu metode pengobatan pada kanker payudara dengan menggunakan zat kimia dan obat obatan yang bersifat sistemik. Kemoterapi memiliki efek samping fisik yang berdampak pada kondisi psikologis sehingga dapat menurunkan kualitas hidup pasien. Salah satu cara untuk meningkatkan kualitas hidup pasien kanker payudara yang sedang menjalani kemoterapi yaitu dengan menggunakan mekanisme koping adaptif. Objektif: Mengetahui hubungan mekanisme koping dengan kualitas hidup pada pasien kanker payudara yang sedang menjalani kemoterapi. Metode: Penelitian ini menggunakan metode cross sectional dengan data primer pasien kanker payudara yang sedang menjalani kemoterapi. Penelitian ini dilaksanakan pada bulan Januari hingga November 2024 dengan jumlah responden sebanyak 36 responden. Teknik pengambilan sampel menggunakan teknik random sampling serta alat pengambilan data menggunakan Jaloweic Coping Scale dan EORTC QLQ C-30. Uji analisis yang digunakan adalah uji chi square. Hasil: Hasil penelitian menunjukkan bahwa mekanisme koping pasien kanker payudara yang sedang menjalani kemoterapi kategori adaptif 77,8%, kualitas hidup kategori baik 72,2%. Terdapat hubungan mekanisme koping dengan kualitas hidup pada pasien kanker payudara yang sedang menjalani kemoterapi dengan nilai p-value = 0,024. Kesimpulan: Terdapat hubungan yang signifikan antara mekanisme koping dengan kualitas hidup pada pasien kanker payudara yang sedang menjalani kemoterapi.

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