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Comparison of Immature Platelet Fraction (IPF) Values for ACS Patients with Unstable Angina Pectoris (UAP), Non-ST Elevation Myocardial Infarct (NSTEMI), and ST Elevation Myocardial Infarct (STEMI) Siregar, Fadhilaturrizqie; Husni; Deswita Sari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1087

Abstract

Background: Acute coronary syndrome (ACS) is a medical emergency that requires rapid diagnosis and treatment. Immature platelet fraction (IPF) is a hematological parameter that has the potential to be a biomarker for differentiating types of ACS. This study aims to compare IPF values in ACS patients with unstable angina pectoris (UAP), Non-ST elevation myocardial infarction (NSTEMI), and ST-elevation myocardial infarction (STEMI). Methods: This research is an analytical observational study with a cross-sectional design. The research subjects were ACS patients treated at Dr. M. Djamil General Hospital, Padang, Indonesia between January 2023 to December 2023. IPF values were measured using the Sysmex XN-1500 tool. Statistical analysis was carried out using the ANOVA test and post-hoc Tukey test. Results: A total of 150 ACS patients (50 UAP, 50 NSTEMI, 50 STEMI) were included in this study. The mean IPF value in the STEMI group (6.8 ± 2.1%) was significantly higher than that in the NSTEMI (4.5 ± 1.8%) and UAP (3.2 ± 1.5%) groups (p < 0.001). ROC analysis showed that the IPF value had an AUC of 0.89 (95% CI: 0.84-0.94) for differentiating STEMI from NSTEMI/UAP. Conclusion: IPF values were higher in STEMI patients compared to NSTEMI and UAP. This parameter has the potential to be a biomarker for differentiating types of ACS, especially in differentiating STEMI from NSTEMI/UAP.
Comparison of Immature Platelet Fraction (IPF) Values for ACS Patients with Unstable Angina Pectoris (UAP), Non-ST Elevation Myocardial Infarct (NSTEMI), and ST Elevation Myocardial Infarct (STEMI) Siregar, Fadhilaturrizqie; Husni; Deswita Sari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1087

Abstract

Background: Acute coronary syndrome (ACS) is a medical emergency that requires rapid diagnosis and treatment. Immature platelet fraction (IPF) is a hematological parameter that has the potential to be a biomarker for differentiating types of ACS. This study aims to compare IPF values in ACS patients with unstable angina pectoris (UAP), Non-ST elevation myocardial infarction (NSTEMI), and ST-elevation myocardial infarction (STEMI). Methods: This research is an analytical observational study with a cross-sectional design. The research subjects were ACS patients treated at Dr. M. Djamil General Hospital, Padang, Indonesia between January 2023 to December 2023. IPF values were measured using the Sysmex XN-1500 tool. Statistical analysis was carried out using the ANOVA test and post-hoc Tukey test. Results: A total of 150 ACS patients (50 UAP, 50 NSTEMI, 50 STEMI) were included in this study. The mean IPF value in the STEMI group (6.8 ± 2.1%) was significantly higher than that in the NSTEMI (4.5 ± 1.8%) and UAP (3.2 ± 1.5%) groups (p < 0.001). ROC analysis showed that the IPF value had an AUC of 0.89 (95% CI: 0.84-0.94) for differentiating STEMI from NSTEMI/UAP. Conclusion: IPF values were higher in STEMI patients compared to NSTEMI and UAP. This parameter has the potential to be a biomarker for differentiating types of ACS, especially in differentiating STEMI from NSTEMI/UAP.
Examining safety knowledge and attitudinal factors related to unsafe conduct among lathe operators Chairani, Alfiah; Hartono, Hartono; Siregar, Santy Deasy; Siregar, Fadhilaturrizqie; Mujahidin, Mujahidin; Sabri, Ihsan; William, Andy; Hutabarat, Bartimeus Nicomama
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7554

Abstract

Background: Unsafe actions are a primary contributor to occupational accidents in industrial environments, yet the influence of worker-specific factors like knowledge and attitude requires continuous investigation. This study aimed to determine the association between Occupational Safety and Health (OSH) knowledge, attitude, and the prevalence of unsafe actions among lathe machine operators. Methods: A cross-sectional study was conducted involving 33 lathe machine operators at CV. Melpura Jaya Teknik. Data on demographic characteristics, OSH knowledge, OSH attitude, and unsafe actions were collected using a structured questionnaire. The relationships between variables were analyzed using the Chi-Square test, with the significance level set at p < 0.05. Results: The analysis revealed a highly significant association between OSH knowledge and unsafe actions (p < .001), as well as a significant association between OSH attitude and unsafe actions (p = .031). Notably, all participants with poor knowledge (100%) or an unsupportive attitude (100%) were found to engage in high-risk unsafe actions. Conversely, all workers with good knowledge or a supportive attitude were classified in the low-risk category. Conclusion: OSH knowledge and attitude are critical determinants of safe behavior among lathe machine operators. Deficiencies in these areas are strongly correlated with high-risk actions. Therefore, workplace safety interventions should adopt a dual approach, focusing not only on comprehensive knowledge-based training but also on fostering a positive safety culture to shape supportive attitudes.