Article Per Year (5 Year)
p-Index From 2020 - 2025
0.983
P-Index
This Author published in this journals
All Journal Jurnal Dunia Farmasi JSMARTech : Journal of Smart Bioprospecting and Technology Jurnal Penelitian Farmasi dan Herbal Jurnal Tumbuhan Obat Indonesia Biosaintifika: Journal of Biology & Biology Education
Rahayu, Lina Oktavia
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search

 1 
Aktivitas Antioksidan dan Antibakteri Tepung Kacang Gude (Cajanus cajan) sebagai Bahan Pembuatan Bioenkapsulasi Lactobacillus Casei Rahayu, Lina Oktavia
Jurnal Dunia Farmasi Vol 8, No 2 (2024): Edisi April
Publisher : LPPM Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v8i2.5481

Abstract

Pendahuluan: Lactobacillus casei merupakan salah satu jenis bakteri yang berfungsi sebagai bakteri probiotik. Idealnya probiotik harus mampu bertahan dan memiliki kemampuan berkembang biak dalam saluran pencernaan. Cara yang perlu dilakukan adalah penambahan prebiotik dan perlindungan probiotik dengan cara bioenkapsulasi. Salah satu jenis bahan alami yang dapat digunakan sebagai prebiotik sekaligus bahan bioenkapsulasi adalah tepung kacang gude (Cajanus cajan), karena mengandung antioksidan dan berfungsi sebagai antibakteri. Tujuan: Untuk mengetahui aktivitas antioksidan tepung kacang gude dan kemampuan biokapsul tepung kacang gude dalam menghambat pertumbuhan bakteri patogen. Metode: Penelitian ini terdiri dari beberapa tahapan yaitu pembuatan tepung kacang gude, ekstraksi tepung kacang gude dengan metode maserasi dengan pelarut etanol 96%, pengujian aktivitas antioksidan dengan metode DPPH, pembuatan biokapsul, dan pengujian aktivitas antibakteri dengan metode difusi sumuran terhadap E. coli. Hasil: Ekstrak tepung kacang gude memiliki nilai IC50 sebesar 850,47 ppm. Ekstrak tepung kacang gude dan biokapsul tepung kacang gude dapat menghambat pertumbuhan E. coli dengan diameter zona bening sebesar 11,01 ± 1,84 mm dan 13,68 ± 2,25 mm. Kesimpulan: Tepung kacang gude memiliki aktivitas antioksidan dengan kategori yang lemah, namun berpotensi untuk dijadikan sebagai bahan bioenkapsulasi bakteri probiotik karena kemampuannya dapat menghambat pertumbuhan bakteri patogen.
AKTIVITAS ANTIOKSIDAN DAN KEMAMPUAN ANTIBAKTERI EKSTRAK KULIT BUAH KENITU (Chrysophyllum cainito L) TERHADAP Staphylococcus aureus Rahayu, Lina Oktavia
Jurnal Penelitian Farmasi & Herbal Vol 6 No 1 (2023): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i1.1564

Abstract

Kenitu (Chrysophyllum cainito L) has strong antioxidant properties both in vitro and in vivo. The presence of this high antioxidant can be used as a natural agent to prevent and treat diseases associated with an imbalance of antioxidant levels in the body, such as diabetes. Some research results state that kenitu can be used as an antidiabetic. One type of complication in people with diabetes mellitus is the occurrence of bacterial infections of the skin. One type of bacteria that infects the most is Staphylococcus aureus. So far, the skin of the kenitu fruit has only been thrown away and has not been used. The purpose of this study was to determine the antioxidant activity of kenitu peel extract and to determine the ability of kenitu peel extract as an antibacterial against Staphylococcus aureus. Research methods included extracting kenitu peel by maceration using 70% ethanol, testing antioxidant activity using the DPPH method, and testing the antibacterial activity of kenitu peel extract against Staphylococcus aureus. The results of the antioxidant activity test showed an IC50 value of 126.96 ppm. Antibacterial activity testing showed a MIC value of 250 ppm and a MBC value of 500 ppm. The conclusion of this study is that kenitu peel extract has moderate antioxidant activity and kenitu peel extract is able to inhibit the growth and kill Staphylococcus aureus bacteria.
Phytochemical Profile and Antioxidant Potential of Tobacco Flower Extract in Different Solvents Wijayanti, Ernanin Dyah; Rahayu, Lina Oktavia; Dzulaikha, Shovia; Ayunda, Fiddini Robetta; Djara, Selfiana
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 5 No. 1 (2024): JSMARTech Volume 5, No. 1, 2024
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2024.005.01.04

Abstract

Tobacco (Nicotiana tabacum) is a commercial plant that is extensively used, particularly for its leaves. Thus far, exploration on the flower part is still limited. The objective of this study was to evaluate the phytochemical profile and antioxidant activity of tobacco flower extracts in different solvents. Tobacco flowers were macerated separately in methanol, ethanol, and n-hexane. Each extract was assayed by color reaction test to detect the phytochemical content. Total phenolic content (TPC) and antioxidant activity were determined by Folin-Ciocalteu and DPPH methods, respectively. Flavonoids, saponins, alkaloids, and triterpenoids are detected in methanol and ethanol extract, anthraquinones is only detected in methanol, while glycosides and steroids are only detected in n-hexane extracts. Among the other extracts, the methanol extract was the richest in phytochemical compounds and had the highest TPC (132.589±0.662 mgGAE/g). However, tobacco flower extract in all solvents were less effective as antioxidant due to very high IC50 values (>500 µg/mL).
Fermented Black Rice Extract (Oryza sativa) Induces Morphological Changes in Pathogenic Microorganisms Wijayanti, Ernanin Dyah; Syafah, Lailiiyatus; Rahayu, Lina Oktavia; Wulandari, Dita; Ibrahim, Zalikha
Biosaintifika: Journal of Biology & Biology Education Vol. 17 No. 1 (2025): Inpress April 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v17i1.17185

Abstract

Black rice (Oryza sativa L.) contains nutrients and bioactive compounds with potential application in health, including antimicrobial properties. To date, the application of fermentation to black rice to enhance its bioactivity, particularly as an antimicrobial, remains unclear. This study aims to evaluate the antimicrobial activity of solid fermented black rice against Gram-positive bacteria, Gram-negative bacteria, and fungi. Black rice was fermented using Saccharomyces cerevisiae under solid-state conditions. Extraction was carried out by maceration using 96% ethanol. Antimicrobial activity was assessed using the well diffusion test method, agar dilution, and scanning electron microscope (SEM). Fermented black rice extract showed antimicrobial activity against all tested microbes. The minimum inhibitory value obtained was 20% against all microbes, but the minimum bactericidal/fungicidal concentration (MBC/MFC) could not be determined. The SEM analysis showed morphological changes in microbes exposed to fermented black rice extract, including cell shrinkage, elongation, and lysis in Bacillus cereus, fragmentation and irregular cell shape in Escherichia coli, cell size reduction in Staphylococcus aureus, and bleb formation in Candida albicans. These changes indicate the mechanism of microbial growth inhibition. We found that fermented black rice (EFBR) extracts produce different effects from unfermented black rice extracts (EUBR), which tend to induce biofilm formation. We propose that EFBR functions as an antimicrobial by rupturing cell walls, preventing cell division and DNA synthesis. This research provides new insights into natural antimicrobial mechanisms at the cellular level and offers a potential alternative for addressing antimicrobial resistance. Solid fermented black rice may serve as a valuable source of antimicrobial compounds for developing health products or natural preservatives.
Characterization of Yellow Tabebuia Flower Extract (Tabebuia aurea) Nanoparticles and Bioactivity as Antioxidant: Karakterisasi Nanopartikel Ekstrak Bunga Tabebuya Kuning (Tabebuia aurea) dan Bioaktivitas sebagai Antioksidan Yunita, Yunita; Syarifah, Anisa Lailatusy; Rahayu, Lina Oktavia; Wijayanti, Ernanin Dyah
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.2174

Abstract

Degenerative diseases can be prevented by natural antioxidants in plant. Yellow tabebuia flower is natural antioxidants. Plant extracts can develope into green synthesis nanoparticle to increase the effectiveness as medicinal materials. This research aims to determine the characteristics of yellow tabebuia flower extract nanoparticles and bioactivity as antioxidants. The methods included preparation and extraction of simplisia using ethanol solvent by maceration and sonication. The extract was determined flavonoid and phenol content by colorimetric method and antioxidant activity by DPPH method. The extract was also made into nano particles by ionic gelation method, with variations addition of tween 80 as much as 0.5, 0.75 and 1 ml. The results of this research are extract has a yield 13.09%, contains flavonoids, tannins, phenolics, alkaloids, saponins and terpenoids. The value of total flavonoid content is 0.59%, total phenolic content is 3.11% and antioxidant activity test has IC50 value of 165.26. The use ionic gelation method can reduce particle size. Three formulas that made the variation surfactant addition has a particle size of 47-283 nm, in addition tween80 1 ml has the smallest particle size of 47 nm with a zeta potential value of 39.3 mV. Keywords: yellow tabebuia flower extract, nanoparticles, antioxidant activity
Co-Authors Ayunda, Fiddini Robetta Djara, Selfiana Dzulaikha, Shovia Ernanin Dyah Wijayanti Ibrahim, Zalikha Syafah, Lailiiyatus Syarifah, Anisa Lailatusy Wulandari, Dita Yunita Yunita