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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Biotropika JRST (Jurnal Riset Sains dan Teknologi) Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ JSMARTech : Journal of Smart Bioprospecting and Technology Berkala Penelitian Hayati Pharmademica: Jurnal Kefarmasian dan Gizi Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Makara Journal of Science Jurnal Tumbuhan Obat Indonesia Metamorfosa: Journal of Biological Science Open Access DRIVERset JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya

Ernanin Dyah Wijayanti

Akademi Farmasi Putra Indonesia Malang

Author-ID : 3527111

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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TOKSISITAS AKUT KOMBUCHA DAUN TIN (Ficus carica) DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT) Uswatun, Uswatun; Wijayanti, Ernanin Dyah
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 3 No. 1 (2020)
Publisher : Sam Ratulangi University

ABSTRACTFig leaves (Ficus carica) contain secondary metabolites such as flavonoids, tannins, alkaloids,saponins and triterpenoids, which potentially toxic in a certain amount. Fermentation of figleaves using kombucha produce healthy drink with various bioactivities. The aim of this researchwas to observe acute toxicity of fig leaves kombucha using Brine Shrimp LethalityTest (BSLT) method. Toxixity test againts Artemia salina Leach larvae using 7 variations infig leaves kombucha concentration from 100 ppm to 30000 ppm. The results showed that figleaves kombucha LC50 value of 139,99 ppm, so that fig leaves kombucha is potentially toxic.Key words: acute toxicity, BSLT, fermentation, fig leavesABSTRAKDaun tin (Ficus carica) mengandung metabolit sekunder antara lain flavonoid, tanin, alkaloid,saponin dan triterpenoid yang berpotensi toksik dalam jumlah tertentu. Fermentasi dauntin oleh kultur kombucha menghasilkan minuman kesehatan dengan berbagai bioaktivitas.Penelitian ini bertujuan untuk mengetahui toksisitas akut kombucha daun tin menggunakanmetode Brine Shrimp Lethality Test (BSLT). Pengujian toksisitas terhadap larva Artemia salinaLeach menggunakan 7 variasi konsentrasi kombucha daun tin antara 100 ppm sampai30000 ppm. Hasil penelitian menunjukkan nilai LC50 kombucha daun tin sebesar 139,99ppm, sehingga disimpulkan bahwa kombucha daun tin berpotensi toksik.Kata kunci: BSLT, daun tin, fermentasi, toksisitas akut

PERBANDINGAN KADAR FENOLIK DAN AKTIVITAS ANTIMIKROBA RIMPANG JERINGAU (Acorus calamus) SEGAR DAN TERFERMENTASI Hardiansi, Fitri; Afriliana, Dwi; Munteira, Anita; Wijayanti, Ernanin Dyah
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 3 No. 1 (2020)
Publisher : Sam Ratulangi University

ABSTRACTCalamus rhizome contain phenolic as antimicrobial agent. Fermentation can increase thereleasing of phenolic content from plant cells. The aim of this research was to observe thecomparison of phenolic content and antimicrobial activity between fresh and fermentedcalamus rhizome extract. Phenolic content was determined by using Folin-Ciocalteu method,and antimicrobial test by agar well diffusion. Phenolic content of fresh and fermentedcalamus rhizome extract respectively are 97,272Â±0,525 and 223,553Â±3,542 mgGAE/gram.Inhibiton zone against Staphylococcus aureus are 4,04Â±0,05 and 8,24Â±0,58 mm, whileagainst Candida albicans are 14,90Â±0,57 and 18,16Â±1,47 mm. Fermentation increase phenoliccontent and antimicrobial activity of calamus rhizome.Key words: antimicrobial, calamus rhozome, fermentation, phenolicABSTRAKRimpang jeringau memiliki kandungan senyawa fenolik sebagai antimikroba. Fermentasidapat meningkatkan pelepasan senyawa fenolik pada sel tanaman. Penelitian ini bertujuanuntuk mengetahui perbandingan kadar fenolik dan aktivitas antimikoba ekstrak rimpangjeringau segar dan terfermentasi. Penetapan kadar fenolik dilakukan dengan metode Folin-Ciocalteu dan uji antimikroba dengan metode difusi sumuran. Kadar fenolik ekstrak jeringausegar dan fermentasi secara berurutan sebesar 97,272Â±0,525 dan 223,553Â±3,542mgGAE/gram. Daya hambat rimpang jeringau segar dan terfermentasi terhadapStaphylococcus aureus sebesar 4,04Â±0,05 dan 8,24Â±0,58 mm, sedangkan terhadap Candidaalbicans sebesar 14,90Â±0,57 dan 18,16Â±1,47 mm. Fermentasi dapat meningkatkan kadarfenolik dan aktivitas antimikroba rimpang jeringau.Kata kunci: antimikroba, fenolik, fermentasi, rimpang jeringau

Uji Potensi Perlekatan Bakteri Asam Laktat Isolat TLA-15 Dan TLA-20 Pada Sel Epitel Usus Tikus (Rattus norvegicus) Ernanin Dyah Wijayanti; Tri Ardyati
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 1 No. 2 (2011): Oktober 2010 - Maret 2011
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/far.v1i2.1171

In Vitro probiotic potential test that had been conducted before, which consist of probiotic bacteria test resistance toward the gastro-intestinal track pH and the bile salt concentration shows that the strain bacteria TLA-15 and TLA-20 had potential as probiotic bacteria. An advance test are required to fullfill the requirement as the probiotic bacteria. So that, the objective of this research are to study the viability of lactic acid bacteria strain TLA-15 and TLA-20 at the Rattus norvegicus GI track. At the first step of this research was added 4 106 cell/ml lactic acid bacteria TLA-15 and TLA-20 given orally.

The effect of lactic acid fermentation on fig (Ficus carica) fruit flavonoid Ernanin Dyah Wijayanti; Nur Candra Eka Setiawan
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 23 No 1 (2017): December 2017
Publisher : The East Java Biological Society

Fig fruit contains a quite high flavonoid that supports the use of it for several disease therapies. Yet, most of the flavonoid in plants is difficult to be digested since it bounds with the glycoside, so the hydrolysis is necessary. The hydrolysis can be done through the lactic acid fermentation. This research aims to determine the effect of lactic acid fermentation on fig fruit flavonoid. Dried fig fruit was prepared into a fig fruit extract and fermented at 37°C for 24 hours using 4 types of starter bacteria; Lactobacillus acidophilus, L. bulgaricus, L. casei and L. plantarum. The fermentation result was identified its flavonoid using dye reaction, determined its flavonoid content using the spectrophotometry with the quercetin standard, and analyzed qualitatively using the LC-MS/MS. The results show that the flavonoid was identified in both before and after the fermentation, but the flavonoid content decreases 30 – 50% after the fermentation. The LC-MS/MS shows that the identified flavonoid is rutin, with the relatively higher percentage after the fermentation. In addition, the catechin and epicatechin are not detected. It can be concluded that the lactic acid fermentation affects the fig fruit flavonoid. The fermentation with all types of starter bacteria decreases the total flavonoid content of fig fruit juice.

Virtual prediction of purple rice ferulic acid as anti-inflammatory of TNF-α signaling Ernanin Dyah Wijayanti; Anna Safitri; Dian Siswanto; Fatchiyah Fatchiyah
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 27 No 2 (2022): June 2022
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/bphjbr.27.2.20221

Purple rice is one of the main sources of ferulic acid (FA). Some studies reported anti-inflammatory properties of FA, but the interaction of FA with TNF-α signaling has not been elucidated. TNF-α is a target for anti-inflammatory drug research due to its major role in the inflammatory process. This study aims to investigate the interaction of FA with TNF-α and TNF-α receptor (TNFR) through in silico study and evaluate the drug-like properties and biological activity of FA. The interactions among FA (CID 445858), TNF-α (2AZ5), and TNFR (1NCF) were docked by Hex 8.0.0 Cuda, then visualized by Discovery Studio 2020 and LigPlot V.1.4.5. Apigenin-7-glucuronide (AG, CID 5319484) was used as the positive control. The drug-like properties were predicted by Lipinski’s rule of five and the biological activity was analyzed by PASS online. FA showed good properties as a drug-like molecule and biological activity as an anti-inflammatory. FA also showed good interaction with TNF-α and TNFR. FA bound to TNF-α at Asn92(B), Val91(B), Leu93(B), Phe124(B), Phe124(D), and Leu93(D) residues with docking energy of -214.6 kJ/mol, and bound to TNFR at Pro16(A), Glu56(B), Cys55(B), Glu54(B) residues with docking energy of -191.1 kJ/mol. FA could inhibit TNF-α – TNFR interaction by binding to TNFR at Glu54 residue, the same inhibition mechanism to AG which bind to TNFR at Glu54 and Val90. The current study shows that FA has the potential as an anti-inflammatory of TNF-α signaling and can be developed as an oral anti-inflammatory drug candidate.

Edukasi dan Pendampingan Pengelola Sayur Organik Baron Agro Lesanpuro Kota Malang Sentot Joko Raharjo; Ernanin Dyah Wijayanti
TRI DHARMA MANDIRI: Diseminasi dan Hilirisasi Riset kepada Masyarakat (Jurnal Pengabdian kepada Masyarakat) Vol 1, No 1 (2021)
Publisher : JTRIDHARMA

Lesanpuro merupakan salah satu wilayah yang memiliki potensi dan daya tarik tersendiri karena memiliki hasil alam yang cukup dan luas lahan pertanian. Hal tersebut membuat wilayah tersebut menjadi penyumbang potensi yang berpengaruh bagi komoditas pertanian kota Malang, khususnya sayur organik dan buah yang sudah sangat jarang sekali ditemui lahan pertanian di tengah kota, namun kelompok usaha ini belum memahami benar arti pentingnya cara produksi yang baik dan keamanan produk pangan sayur organik. Edukasi dan pendampingan kelompok usaha pengolahan sayur organik yang benar dan pengetahuan meliputi semua aspek penanganan bisnis tersebut. Tujuan pengabdian masyarakat ini adalah edukasi dan pendampingan kelompok usaha dalam pengelolaan sayur organik yang baik agar menjadi produk pangan yang aman sehingga menjadi peluang usaha baru untuk meningkatkan kesejahteraan dan kemandirian dalam lingkungan, kesehatan, dan perekonomian. Metode yang digunakan adalah PAR (Participatory Action Research) berupa penyuluhan, pelatihan, demonstrasi, serta pendampingan. Pendampingan dilakukan selama 3 bulan. Hasil pendampingan menunjukkan bahwa 95% responden setuju bahwa kegiatan pengabdian kepada masyarakat bermanfaat, 89% responden setuju kegiatan edukasi ini sangat meningkatkan kualitas, 97% responden menyatakan ilmu bertambah setelah mengikuti pelatihan, dan 85% responden menyatakan bahwa keseluruhan kegiatan pelatihan sudah baik. Kesimpulan pengabdian adalah kegiatan edukasi dan pendampingan kelompok usaha dalam pengelolaan sayur organik agar menjadi produk pangan yang aman mendapatkan respons yang baik dan menjadi peluang usaha baru untuk meningkatkan kesejahteraan dan kemandirian dalam lingkungan, kesehatan, dan perekonomian.

Eksplorasi Ekstrak Etanol Beberapa Tumbuhan Berpotensi Sebagai Antiketombe Ernanin Dyah Wijayanti; Endang Susilowati
JRST (Jurnal Riset Sains dan Teknologi) Volume 1 No. 2 September 2017: JRST
Publisher : Universitas Muhammadiyah Purwokerto

Abstrak Ketombe merupakan salah satu masalah rambut yang disebabkan oleh fungi Malassezia furfur sehingga untuk pengendaliannya diperlukan agen antifungi. Beberapa tumbuhan telah digunakan secara empiris untuk terapi antiketombe antara lain: inggu (Ruta angustifolia), bambu tali (Gigantochloa apus), johar (Senna siamea), jintan hitam (Nigella sativa), apukat (Persea americana), dadap serep (Erythrina lithosprema), nagasari (Palaquium rostratum), pisang (Musa paradisiaca), sidaguri (Sida rhombifolia), tomat (Solanum lycopersicum), kethuk (Alocasia macrorrhiza) dan komak (Dolichos lablab). Penelitian ini bertujuan untuk membuktikan aktivitas antifungi ekstrak etanol tumbuhan uji dan menentukan nilai Kadar Hambat Minimum (KHM) dan Kadar Bunuh Minimumnya (KBM). Masing-masing simplisia tumbuhan uji diekstraksi dengan metode maserasi menggunakan pelarut etanol 70% selama 5 hari. Pengujian aktivitas antifungi terhadap Malassezia furfur menggunakan metode difusi sumuran, yang dilanjutkan dengan penentuan KHM dan KBM dengan metode dilusi. Hasil penelitian menunjukkan bahwa semua ekstrak etanol tumbuhan uji memiliki aktivitas antifungi yang bervariasi terhadap Malassezia furfur. Aktivitas yang kuat ditunjukkan oleh ekstrak etanol kulit buah pisang, daun bambu tali, daun komak, biji jintan hitam dan daun inggu. Nilai KHM masing-masing ekstrak antara lain: kulit buah pisang, daun bambu tali dan daun komak (10%), biji jintan hitam (20%), daun inggu (30%), daun dadap serep dan daun johar (50%), daun tomat (60%), daun apukat dan daun nagasari (70%). Ekstrak etanol daun sidaguri dan daun kethuk tidak memiliki nilai KHM. Semua ekstrak etanol tumbuhan uji tidak memiliki nilai Kadar Bunuh Minimum (KBM). Kata kunci: antifungi, ekstrak etanol, ketombe Abstract Dandruff is one of hair problem caused by Malassezia furfur, which can be controlled by antifungal agents. Empirically, some plants have been used as antidandruff treatment: rue (Ruta angustifolia), bamboo tali (Gigantochloa apus), blackwood cassia (Senna siamea), black cummin (Nigella sativa), avocado (Persea americana), Indian coral tree (Erythrina lithosprema), gutta percha (Palaquium rostratum), banana (Musa paradisiaca), cuban jute (Sida rhombifolia), tomato (Solanum lycopersicum), taro (Alocasia macrorrhiza) and lablab (Dolichos lablab). This research was aimed to observe antifungal activity, Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of these 12 potential plants against Malassezia furfur. Each of plant simplisia was extracted by immersion in 70% ethanol for 5 days. Antifungal activity assay against Malassezia furfur were conducted using agar well diffusion, followed by dilution method to determine MIC and MFC. The results showed that all of plant ethanolic extract have various antifungal activity against Malassezia furfur. Strong activity showed by banana peels extract, bamboo tali leaves extract, lablab leaves extract, black cumin seeds extract and rue leaves extract. MIC values obtained were 10 % for banana peels extract, bamboo tali and lablab leaves extract, 20% for black cumin seeds extract, 30% for rue leaves extract, 50% for Indian coral and blackwood cassia leaves extract, 60% for tomato leaves extract, 70% for avocado and gutta percha leaves extract. Whereas cuban jute and taro leaves extract did not show MIC values. All of plant ethanolic extracts did not show MFC values. Key words: antifungal, dandruff, ethanolic extract

Antimicrobial Activity of Ferulic Acid in Indonesian Purple Rice through Toll-like Receptor Signaling Wijayanti, Ernanin Dyah; Safitri, Anna; Siswanto, Dian; Triprisila, Lidwina Faraline; Fatchiyah, Fatchiyah
Makara Journal of Science Vol. 25, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Purple rice is a potential source of ferulic acid, which has antimicrobial properties. However, the inhibitory mechanism of ferulic acid on the growth of bacteria, particularly Salmonella and Listeria, has not been elucidated. This study aimed to determine the bioactivity of ferulic acid from purple rice as an antimicrobial agent against Salmonella typhimurium and Listeria monocytogenes using in vitro and in silico analyses. The antimicrobial activity of a purple rice ferulic acid extract was tested using the agar well diffusion method. Its effect on bacterial cells was observed using scanning electron microscopy. Ferulic acid was confirmed to have antimicrobial properties using in silico software to attenuate the binding of bacterial virulence factors (lipoproteins, lipopolysaccharides, and flagellins) to Toll-like receptors (TLRs) and to prevent interactions with peptidoglycans. The purple rice ferulic acid extract inhibited bacterial growth. The inhibitory effects included induction of a biofilm and shrinkage of S. Typhimurium, as well as osmotic lysis of L. monocytogenes. This activity was supported by the ability of ferulic acid to inhibit the binding of bacterial virulence factors with TLRs and block bacterial peptidoglycans. These findings indicate that the purple rice ferulic acid extract acts as antimicrobial, both directly to bacterial cells and indirectly through TLRs. We conclude that ferulic acid from Indonesian purple rice has a biological function as an antimicrobial agent.

Kombucha Batang Pisang Kepok: Kadar Fenolik Total, Aktivitas Antibakteri, dan Pengaruh terhadap Viabilitas Lactobacillus gasseri Nur Laela; Fitri Husniatin Nisa; Riki Purwosutanto; Nur Hayati; Ernanin Dyah Wijayanti
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 2 No 2 (2023): Oktober - Maret
Publisher : LPPMKI - AKAFARMA AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v2i2.32

Kepok banana pseudo stem (Musa acuminate balbisiana Colla) contains several secondary metabolites which have potential as antioxidants and antibacterials. Fermentation is known to increase the levels of phenolic compounds and their bioactivity. This study aims to analyze the effect of kombucha fermentation of kepok banana pseudo stems on total phenolic content, antibacterial activity and its effect on the viability of Lactobacillus gasseri. Banana pseudo stems were fermented with kombucha culture for 12 days at room temperature, the total phenolic content was determined by the Folin-Ciocalteu method, the antibacterial activity was tested by the well diffusion method, while the viability of L. gasseri was determined by the Total Plate Count (TPC) method. The total phenolic content of kepok banana stems increased by 60.88% after being fermented with kombucha, but the kombucha of kepok banana pseudo stems did not show antibacterial activity against Escherichia coli and caused a decrease in the viability of L. gasseri. This study shows that kombucha fermentation is beneficial for increasing phenolic levels and has potential as an antibacterial, especially against Gram positive groups.

Phytochemical Profile and Antioxidant Potential of Tobacco Flower Extract in Different Solvents Wijayanti, Ernanin Dyah; Rahayu, Lina Oktavia; Dzulaikha, Shovia; Ayunda, Fiddini Robetta; Djara, Selfiana
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 5 No. 1 (2024): JSMARTech Volume 5, No. 1, 2024
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2024.005.01.04

Tobacco (Nicotiana tabacum) is a commercial plant that is extensively used, particularly for its leaves. Thus far, exploration on the flower part is still limited. The objective of this study was to evaluate the phytochemical profile and antioxidant activity of tobacco flower extracts in different solvents. Tobacco flowers were macerated separately in methanol, ethanol, and n-hexane. Each extract was assayed by color reaction test to detect the phytochemical content. Total phenolic content (TPC) and antioxidant activity were determined by Folin-Ciocalteu and DPPH methods, respectively. Flavonoids, saponins, alkaloids, and triterpenoids are detected in methanol and ethanol extract, anthraquinones is only detected in methanol, while glycosides and steroids are only detected in n-hexane extracts. Among the other extracts, the methanol extract was the richest in phytochemical compounds and had the highest TPC (132.589±0.662 mgGAE/g). However, tobacco flower extract in all solvents were less effective as antioxidant due to very high IC50 values (>500 µg/mL).

Co-Authors Afriliana, Dwi Agustanti, Khalimatus Nur Eka Ayunda, Fiddini Robetta Dewi Ratih Tirto Sari Dian Siswanto Djara, Selfiana Dzulaikha, Shovia Eko Suyanto Elrica Maggian Murelina Elwin Dwi Novitasari Elwin Dwi Novitasari Endang Susilowati fatchiyah . Fatchiyah Fatchiyah Fitri Husniatin Nisa Hardiansi, Fitri Husnah, Yeni Avidhatul Lidwina Faraline Triprisila Linda Jaushica Yustin Maurin Ardhina Syafiudin Munteira, Anita Noor Annisa Susanto Nur Hayati Nur Laela nurmiati Dyah nurmiati Oktavina Kartika Putri Rahayu, Lina Oktavia Riki Purwosutanto Safitri, Anna Sentot Joko Raharjo Sentot Joko Raharjo Setiawan, Nur Candra Eka Syarifah, Anisa Lailatusy Tri Ardyati Uswatun, Uswatun Yunita Yunita

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