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All Journal Jurnal Wiyata : Penelitian Sains dan Kesehatan Jurnal Dunia Farmasi
Octaviani, Adinda Tri
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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Formulasi Sediaan Gel Sari Buah Belimbing Wuluh (Averrhoa bilimbi L.) menggunakan Iota Karaginan sebagai Gelling Agent dan Uji Aktivitas terhadap Bakteri Propionibacterium acne dan Staphylococcus epidermidis Silvyana, Annysa Ellycornia; Octaviani, Adinda Tri; Reubun, Yonathan Tri Atmodjo
Jurnal Dunia Farmasi Vol 8, No 3 (2024): Edisi Agustus
Publisher : LPPM Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v8i3.6127

Abstract

Pendahuluan: Buah belimbing wuluh mengandung zat nutrisi yang banyak seperti fenol dan flavonoid yang mempunyai aktivitas sebagai antijerawat. Tujuan : Penelitian ini bertujuan untuk mengetahui stabilitas sediaan gel sari buah belimbing wuluh dan aktivitasnya terhadap bakteri penyebab jerawat. Pada penelitian ini terdapat 3 formula gel dengan konsentrasi sari buah belimbing wuluh yang berbeda yaitu 50%, 25%, dan 10%. Metode: Pada penelitian ini sari buah belimbing wuluh diformulasikan dalam bentuk sediaan gel dengan iota karaginan sebagai gelling agent. Tiap formula gel di evaluasi meliputi pengamatan organoleptik, pH, homogenitas, viskositas, dan uji stabilitas fisik dengan metode shelf-life dan sentrifugasi, serta uji aktivitas antibakteri. Hasil: Berdasarkan hasil, semakin besar konsentrasi sari buah belimbing wuluh warna gel semakin tua, pH semakin asam dan viskositas semakin besar. Dan pada hasil uji statistik LSD aktivitas antibakteri didapatkan hasil KHM terbaik yaitu pada formula 1 (50%) dengan luas diameter zona hambat rata-rata 8,68 mm terhadap bakteri Propionibacterium acne dan 9,34 mm terhadap bakteri Staphylococcus epidermidis yang mendekati kontrol positif. Kesimpulan: Disimpulkan bahwa semakin besar konsentrasi sari buah belimbing wuluh semakin besar dimeter zona hambat yang terbentuk. Ketiga formula dapat menghambat pertumbuhan bakteri Propionibacterium acne dan Staphylococcus epidermidis
POTENSI EKSTRAK BENALU TEH (Scurrula oortiana Dans.) TERHADAP BAKTERI PENYEBAB JERAWAT Staphylococcus epidermidis DAN Staphylococcus aureus Reubun, Yonathan Tri Atmodjo; Silvyana, Annysa Ellycornia; Warti, Lia; Octaviani, Adinda Tri
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 12, No 1 (2025)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v12i1.919

Abstract

Acne is a disease in which there is a buildup of skin oil glands which results in clogged skin pores, causing excess fat deposits. Bacteria such as Staphylococcus epidermidis and Staphylococcus aureus are the main factors in the emergence of this acne disease. The use of natural medicine can be used to test the inhibitory activity of both bacteria, one of which is tea mistletoe. The purpose of this study was to obtain the inhibitory activity of bacteria such as Staphylococcus epidermidis and Staphylococcus aureus from tea mistletoe extract using the liquid dilution method, namely MIC and MBC. The concentrations used consisted of 100000ppm, 50000 ppm, 25000ppm, 12500 ppm, 6250ppm, and 3125ppm. The MIC method is based on the turbidity or clarity of the test solution, while the MBC is based on the concentration of the extract in the media used. The results of the study showed that tea mistletoe extract has the potential to inhibit at 50,000ppm and above on both bacteria with the MIC method and kill at a concentration of 50,000ppm on S.aureus bacteria and 25,000ppm on S.epidermidis. The conclusion of this study is that tea mistletoe extract has the potential to inhibit and kill S.epidermidis and S.aureus bacteria at a concentration of 50,000ppm on the MIC and 25,000ppm on the MBC method.
POTENSI EKSTRAK BENALU TEH (Scurrula oortiana Dans.) TERHADAP BAKTERI PENYEBAB JERAWAT Staphylococcus epidermidis DAN Staphylococcus aureus Reubun, Yonathan Tri Atmodjo; Silvyana, Annysa Ellycornia; Warti, Lia; Octaviani, Adinda Tri
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 12 No 1 (2025)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v12i1.919

Abstract

Acne is a disease in which there is a buildup of skin oil glands which results in clogged skin pores, causing excess fat deposits. Bacteria such as Staphylococcus epidermidis and Staphylococcus aureus are the main factors in the emergence of this acne disease. The use of natural medicine can be used to test the inhibitory activity of both bacteria, one of which is tea mistletoe. The purpose of this study was to obtain the inhibitory activity of bacteria such as Staphylococcus epidermidis and Staphylococcus aureus from tea mistletoe extract using the liquid dilution method, namely MIC and MBC. The concentrations used consisted of 100000ppm, 50000 ppm, 25000ppm, 12500 ppm, 6250ppm, and 3125ppm. The MIC method is based on the turbidity or clarity of the test solution, while the MBC is based on the concentration of the extract in the media used. The results of the study showed that tea mistletoe extract has the potential to inhibit at 50,000ppm and above on both bacteria with the MIC method and kill at a concentration of 50,000ppm on S.aureus bacteria and 25,000ppm on S.epidermidis. The conclusion of this study is that tea mistletoe extract has the potential to inhibit and kill S.epidermidis and S.aureus bacteria at a concentration of 50,000ppm on the MIC and 25,000ppm on the MBC method.
Co-Authors Annysa Ellycornia Silvyana Reubun, Yonathan Tri Atmodjo Warti, Lia