Article Per Year (5 Year)
p-Index From 2020 - 2025
0.562
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran Brawijaya Majalah Kesehatan FKUB
Hartanti, Khoirunisah Dwi
Unknown Affiliation
Medicine & Pharmacology Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Thromboelastography Profile of Covid-19 Patients Before and After Convalescent Plasma Therapy Administration Fatonah, Siti; Xaveria, Xaveria; Hartanti, Khoirunisah Dwi; Purnamasari, Putri; Ningtyas, Denina Setya; Ramadhani, Saskia
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.11

Abstract

In Covid-19 patients, coagulopathy disorder is commonly characterized as hypercoagulable, although hemorrhagic complications can arise. However, thromboelastography (TEG) is an examination tool with the ability to assess the complete hemostasis process, including primary, secondary, and fibrinolysis stages, closely resembling the in vivo coagulation process. Therefore, this study provides a descriptive analysis of the hemostatic state of Covid-19 patients before and after administration of convalescent plasma therapy using TEG. In this study, the blood sample was collected from 21 Covid-19 patients at RSSA Malang from June to November 2020, followed by a TEG examination, which was performed on the first day of admission and after convalescent plasma therapy administration. The results were analyzed descriptively. Before convalescent plasma therapy, coagulation index (CI) analysis of TEG results in 21 patients showed that 62% exhibited normocoagulability, 23.8% were hypercoagulable, and 14.2% used hypercoagulability. While TEG results after convalescent plasma therapy showed that 71.4% were normocoagulable, 4.7% hypocoagulable, and 23.9% hypercoagulable. Based on TEG parameters, R, K, and MA, before administration of convalescent plasma therapy showed decreased platelet function by 38%, primary fibrinolysis by 5%, secondary fibrinolysis by 10%, platelet hypercoagulability 5%, and 43% was normal. Coagulopathy profile after convalescent plasma therapy showed decreased platelet function by 24%, secondary fibrinolysis by 10%, platelet hypercoagulability by 10%, enzymatic hypercoagulability by 5%, enzymatic and platelet hypercoagulability by 5%, and 48% was normal. TEG in Covid-19 patients showed a hypercoagulable state before and after administration of convalescent plasma therapy
Tinjauan Literatur: SITOKIN SEBAGAI PREDIKTOR MORTALITAS CORONAVIRUS DISEASE-19 (COVID-19): A SYSTEMATIC REVIEW Iskandar, Agustin; Hartanti, Khoirunisah Dwi
Majalah Kesehatan Vol. 11 No. 1 (2024): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2024.011.01.8

Abstract

Peningkatan kadar sitokin berperan pada terjadinya badai sitokin yang menyebabkan sindrom distres nafas dan kerusakan organ sehingga banyak studi yang mengungkapkan hubungan peningkatan sitokin terhadap keparahan Coronavirus Disease-19 (COVID-19). Sitokin yang dilaporkan berhubungan dengan keparahan penyakit ternyata tidak selalu terbukti berhubungan dengan mortalitas pada COVID-19. Kami melakukan review hubungan sitokin dengan mortalitas COVID-19 dan potensinya sebagai biomarker prediktor mortalitas COVID-19. Review literatur secara sistematik dilakukan pada database PubMed dan ScienceDirect. Kata kunci yang digunakan adalah ‘cytokine’, ‘mortality’, ‘COVID-19’, dan ‘predictor’. Hanya studi observasional yang membahas hubungan antara sitokin dengan mortalitas pada COVID-19 yang masuk sebagai kriteria inklusi. Didapatkan 15 artikel yang relevan dan melaporkan hubungan sitokin dengan mortalitas COVID-19. Peningkatan kadar sitokin IL-6 berhubungan pada mortalitas pada sepuluh studi. Peningkatan TNF-α dan IL-8 memiliki hubungan dengan mortalitas dan dilaporkan pada empat studi. Peningkatan IL-10 berhubungan dengan mortalitas pada tiga studi. Beberapa sitokin lain diungkapkan hubungannya dengan mortalitas tetapi hanya terbukti pada satu studi, antara lain peningkatan kadar IFN-γ, IL-1β, dan MCP-1. Dapat disimpulkan, sitokin IL-6 berhubungan dengan mortalitas pada COVID-19. Sitokin  TNF-α, IFN-γ, IL-8, IL-10, IL-1β, dan MCP-1 tidak banyak dilaporkan hubungannya dengan mortalitas pada COVID-19. Akan tetapi sitokin tersebut memiliki hubungan dengan keparahan penyakit COVID-19 sehingga memiliki potensi untuk diteliti lebih lanjut sebagai prediktor mortalitas pada COVID-19.
Thromboelastography Profile of Covid-19 Patients Before and After Convalescent Plasma Therapy Administration Fatonah, Siti; Xaveria, Xaveria; Hartanti, Khoirunisah Dwi; Purnamasari, Putri; Ningtyas, Denina Setya; Ramadhani, Saskia
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.11

Abstract

In Covid-19 patients, coagulopathy disorder is commonly characterized as hypercoagulable, although hemorrhagic complications can arise. However, thromboelastography (TEG) is an examination tool with the ability to assess the complete hemostasis process, including primary, secondary, and fibrinolysis stages, closely resembling the in vivo coagulation process. Therefore, this study provides a descriptive analysis of the hemostatic state of Covid-19 patients before and after administration of convalescent plasma therapy using TEG. In this study, the blood sample was collected from 21 Covid-19 patients at RSSA Malang from June to November 2020, followed by a TEG examination, which was performed on the first day of admission and after convalescent plasma therapy administration. The results were analyzed descriptively. Before convalescent plasma therapy, coagulation index (CI) analysis of TEG results in 21 patients showed that 62% exhibited normocoagulability, 23.8% were hypercoagulable, and 14.2% used hypercoagulability. While TEG results after convalescent plasma therapy showed that 71.4% were normocoagulable, 4.7% hypocoagulable, and 23.9% hypercoagulable. Based on TEG parameters, R, K, and MA, before administration of convalescent plasma therapy showed decreased platelet function by 38%, primary fibrinolysis by 5%, secondary fibrinolysis by 10%, platelet hypercoagulability 5%, and 43% was normal. Coagulopathy profile after convalescent plasma therapy showed decreased platelet function by 24%, secondary fibrinolysis by 10%, platelet hypercoagulability by 10%, enzymatic hypercoagulability by 5%, enzymatic and platelet hypercoagulability by 5%, and 48% was normal. TEG in Covid-19 patients showed a hypercoagulable state before and after administration of convalescent plasma therapy
Co-Authors Agustin Iskandar Ningtyas, Denina Setya Putri Purnamasari Ramadhani, Saskia Siti Fatonah Xaveria, Xaveria