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All Journal Jurnal Kedokteran Brawijaya Journal of Innovation and Applied Technology
Ningtyas, Denina Setya
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Computer Science & IT Medicine & Pharmacology

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Thromboelastography Profile of Covid-19 Patients Before and After Convalescent Plasma Therapy Administration Fatonah, Siti; Xaveria, Xaveria; Hartanti, Khoirunisah Dwi; Purnamasari, Putri; Ningtyas, Denina Setya; Ramadhani, Saskia
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.11

Abstract

In Covid-19 patients, coagulopathy disorder is commonly characterized as hypercoagulable, although hemorrhagic complications can arise. However, thromboelastography (TEG) is an examination tool with the ability to assess the complete hemostasis process, including primary, secondary, and fibrinolysis stages, closely resembling the in vivo coagulation process. Therefore, this study provides a descriptive analysis of the hemostatic state of Covid-19 patients before and after administration of convalescent plasma therapy using TEG. In this study, the blood sample was collected from 21 Covid-19 patients at RSSA Malang from June to November 2020, followed by a TEG examination, which was performed on the first day of admission and after convalescent plasma therapy administration. The results were analyzed descriptively. Before convalescent plasma therapy, coagulation index (CI) analysis of TEG results in 21 patients showed that 62% exhibited normocoagulability, 23.8% were hypercoagulable, and 14.2% used hypercoagulability. While TEG results after convalescent plasma therapy showed that 71.4% were normocoagulable, 4.7% hypocoagulable, and 23.9% hypercoagulable. Based on TEG parameters, R, K, and MA, before administration of convalescent plasma therapy showed decreased platelet function by 38%, primary fibrinolysis by 5%, secondary fibrinolysis by 10%, platelet hypercoagulability 5%, and 43% was normal. Coagulopathy profile after convalescent plasma therapy showed decreased platelet function by 24%, secondary fibrinolysis by 10%, platelet hypercoagulability by 10%, enzymatic hypercoagulability by 5%, enzymatic and platelet hypercoagulability by 5%, and 48% was normal. TEG in Covid-19 patients showed a hypercoagulable state before and after administration of convalescent plasma therapy
Pencegahan Penyakit Diabetes Melitus pada Masyarakat Desa Ngadiwono Kecamatan Tosari Kabupaten Pasuruan dengan DEM (Deteksi, Edukasi, dan Monitoring) Firani, Novi Khila; Permatasari, Happy Kurnia; Wahono, Singgih Pudjo; Soraya, Mira; Purnamasari, Putri; Ningtyas, Denina Setya
Journal of Innovation and Applied Technology Vol 8, No 2 (2022)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jiat.2022.008.02.14

Abstract

Penyakit Diabetes Melitus merupakan penyakit metabolik yang ditandai  peningkatan kadar gula dalam darah. Penyakit ini merupakan penyakit degeneratif yang berlangsung kronis, sehingga seringkali menyebabkan berbagai komplikasi. Komplikasi akibat Diabetes Melitus dapat menyebabkan meningkatnya angka kematian.  Insiden penyakit Diabetes Melitus meningkat dengan bertambahnya usia. Skrining penyakit Diabetes Melitus dilakukan melalui pemeriksaan kadar gula darah sewaktu. Selanjutnya dilakukan edukasi dengan ceramah kesehatan dan pemberian brosur. Tahapan terakhir yaitu monitoring, dengan melakukan pemeriksaan kadar glukosa darah kembali di akhir program. Sasaran program pengabdian masyarakat ini adalah masyarakat usia lansia dan pralansia di Desa Ngadiwono, Kecamatan Tosari, Kabupaten Pasuruan. Hasil kegiatan pengabdian masyarakat ini menunjukkan bahwa terdapat penurunan persentase warga yang memiliki kadar gula darah kategori Diabetes Melitus.   
Thromboelastography Profile of Covid-19 Patients Before and After Convalescent Plasma Therapy Administration Fatonah, Siti; Xaveria, Xaveria; Hartanti, Khoirunisah Dwi; Purnamasari, Putri; Ningtyas, Denina Setya; Ramadhani, Saskia
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.11

Abstract

In Covid-19 patients, coagulopathy disorder is commonly characterized as hypercoagulable, although hemorrhagic complications can arise. However, thromboelastography (TEG) is an examination tool with the ability to assess the complete hemostasis process, including primary, secondary, and fibrinolysis stages, closely resembling the in vivo coagulation process. Therefore, this study provides a descriptive analysis of the hemostatic state of Covid-19 patients before and after administration of convalescent plasma therapy using TEG. In this study, the blood sample was collected from 21 Covid-19 patients at RSSA Malang from June to November 2020, followed by a TEG examination, which was performed on the first day of admission and after convalescent plasma therapy administration. The results were analyzed descriptively. Before convalescent plasma therapy, coagulation index (CI) analysis of TEG results in 21 patients showed that 62% exhibited normocoagulability, 23.8% were hypercoagulable, and 14.2% used hypercoagulability. While TEG results after convalescent plasma therapy showed that 71.4% were normocoagulable, 4.7% hypocoagulable, and 23.9% hypercoagulable. Based on TEG parameters, R, K, and MA, before administration of convalescent plasma therapy showed decreased platelet function by 38%, primary fibrinolysis by 5%, secondary fibrinolysis by 10%, platelet hypercoagulability 5%, and 43% was normal. Coagulopathy profile after convalescent plasma therapy showed decreased platelet function by 24%, secondary fibrinolysis by 10%, platelet hypercoagulability by 10%, enzymatic hypercoagulability by 5%, enzymatic and platelet hypercoagulability by 5%, and 48% was normal. TEG in Covid-19 patients showed a hypercoagulable state before and after administration of convalescent plasma therapy
Co-Authors Happy Kurnia Permatasari Hartanti, Khoirunisah Dwi Novi Khila Firani Putri Purnamasari Ramadhani, Saskia Siti Fatonah Soraya, Mira Wahono, Singgih Pudjo Xaveria, Xaveria