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Sukotjo, Cortino
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Biochemistry, Genetics & Molecular Biology Dentistry Immunology & microbiology Medicine & Pharmacology Public Health

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The effect of (3-aminopropyl) triethoxysilane and curcumin coating on the physicochemistry of Fe 3 O 4 particles as theranostics of oral cancer: qualitative study descriptive Yohannes, Gabriel; Djustiana, Nina; Mardhian, Deby Fajar; Sukotjo, Cortino; Aripin, Dudi
Padjadjaran Journal of Dental Researchers and Students Vol 7, No 3 (2023): Oktober 2023
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v7i3.48079

Abstract

ABSTRACTIntroduction: Superparamagnetic iron oxide nanoparticles (SPION) has been used in MRI and have the capability to conjugate with different ligands. One of the active ingredients of interest in biomedical application is curcumin (Cur), which has been shown to have anti-inflammatory effect, wound healing property, and anti-cancer activity. However, such conjugation may need to be facilitated by polymer, such as 3-aminopropyltrimethoxysilane (AMPTS). This study aims to describe the effect of coating materials AMPTS and Cur on the physicochemistry of Fe3O4 particles as a diagnostic of oral cancer. Methods: Modified SPIONs were synthesized by a simple coprecipitation method. Fe3O4 particles were characterized using Fourier transform infrared spectroscopy (FTIR) to analyze the conjugation yield. Next, modified SPIONs were analyzed using dynamic light scattering (DLS) to examine size distribution. Furthermore, zeta potential of the particles was examined. Results: DLS showed size increases after modification of SPION with different materials. In addition, there were slight changes in zeta potential. However, FTIR showed no differences in peaks, indicating that no conjugation was successful. Conclusion: Although FTIR showed no differences in peaks, DLS and zeta potential showed changes with different coatings, which may indicate conjugation. However, further analyses must be carried out to quantify the conjugation yield.KEYWORDS: AMPTS, curcumin, iron oxide, oral cancer, coprecipitationPengaruh bahan pelapis AMPTS dan kurkumin terhadap fisikokimia partikel Fe3O4 sebagai teragnostik kanker mulut: studi deskriptifABSTRAKPendahuluan: Superparamagnetic iron oxide nanoparticle (SPION) telah digunakan dalam MRI dan memiliki kemampuan untuk dikonjugasi dengan berbagai ligan. Salah satu bahan aktif yang menjadi sorotan di bidang biomedis adalah curcumin yang memiliki sifat anti-inflamasi, penyembuhan luka, dan aktivitas anti-kanker. Akan tetapi, konjugasi tersebut biasanya memerlukan fasilitator berupa polimer, seperti 3-aminopropyltrimethoxysilane (AMPTS). Penelitian ini bertujuan untuk mendeskripsikan pengaruh bahan pelapis 3-aminopropyltrimethoxysilane (AMPTS) dan kurkumin (Cur) terhadap fisikokimia partikel Fe3O4 sebagai teragnostik kanker mulut. Metode: SPION disintesis dan dimodifikasi dengan bahan-bahan pelapis tersebut melalui metode kopresipitasi sederhana. Untuk menganalisis hasil konjugasi, sampel dikarakterisasi dengan fourier transform infrared spectroscopy (FTIR). Berikutnya, sampel dianalisis dengan dynamic light scattering (DLS) untuk melihat distribusi ukuran. Kemudian, potensial zeta sampel diukur. Hasil: DLS menunjukkan peningkatan ukuran setelah modifikasi SPION dengan bahan pelapis. Selain itu, ada perubahan dalam potensial zeta. Akan tetapi, analisis FTIR tidak menunjukkan perbedaan puncak serapan yang mengindikasikan ketiadaan konjugasi. Simpulan: Meskipun FTIR tidak menunjukkan perbedaan puncak serapan setiap sampel, DLS dan potensial zeta menunjukkan perubahan nilai untuk setiap sampel dengan coating berbeda, yang boleh jadi mengindikasikan konjugasi. Akan tetapi, analisis lebih lanjut perlu dilakukan untuk mengkuantifikasi konjugasi.KATA KUNCI: AMPTS, kurkumin, besi oksida, kanker mulut, kopresipitasi
Differences of room temperature vulcanized silicone and dimensional accuracy towards silicone PVS light body impression: Study experimental Kambolong, Sitti Annisa; Masyhudi, Masyhudi; Sulistiani, Dewi Arsih; Asfirizal, Verry; Irsal, Imran; Sukotjo, Cortino
Padjadjaran Journal of Dental Researchers and Students Vol 9, No 2 (2025): Juni 2024
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v9i2.62117

Abstract

ABSTRAKIntroduction: Dental impressions are materials used to accurately replicate. Silicon Room Temperature Vulcanized (RTV) impression material is known to have good ultimate tensile strength and flexibility. Polyvinyl siloxane light body impression (low viscosity) which has the same viscosity as RTV material. Dimensional accuracy is used to see the accuracy of the impression material. Objective to investigate the optimal ratio of base, catalyst, and filler for RTV silicone to achieve the setting time and working time. To investigate is a difference between treatments using fillers and not using fillers. To investigate the difference in dimensional accuracy between the two materials. Methods: This research is pure experimental researches with randomized post-test only control group design. The control group was PVS light body silicone and the treatment group was RTV silicone. RTV silicones were categorized into 6 treatment groups. The treatments were increasing the amount of catalyst and adding talc filler. Each treatment group had 4 replications. Based on data analysis, there was no difference in the average. Results: The results showed that RTV silicone had significant difference with p < 0.05. At the ratio of RTV treatment groups without fillers by using fillers had a real difference with p < 0.05. In terms of dimensional accuracy, RTV silicone and silicone with light body impression viscosity did not have significant difference with p > 0.05. Conclusion: The optimal ratio for RTV silicon is 10:2 with the addition of 10 grams of talc filler. In the treatment using filler and without filler, having original fabrics with faster results was found in the filler treatment group. There is no significant difference in dimensional accuracy between RTV silicone and silicone with light body impression viscosity, so that both materials have the same accuracy.KEY WORDS: Room temperature vulcanized (RTV) silicone, light body impression, dimensional accuracyPerbandingan silikon room temperature vulcanized   dan akurasi dimensi terhadap silikon PVS light body impression dalam kedokteran gigi : studi eksperimentalABSTRAKPendahuluan: cetakan gigi adalah bahan yang digunakan untuk membuat replika atau tiruan yang akurat. Bahan cetak Silicon Room Temperature Vulcanized (RTV) diketahui memiliki ultimate tensile strength serta kelenturan yang baik. Bahan polyvinyl siloxane (PVS) light body (viskositas rendah) yang memiliki viskositas sama dengan bahan RTV. Akurasi dimensi digunakan untuk melihat keakuratan bahan cetak. Metode: Penelitian ini bermetode eksperimental murni dengan desain penelitian Randomized post-test only control group design. Kelompok kontrol adalah Silikon PVS light body dan kelompok perlakuan adalah Silikon RTV. Silikon RTV dikelompokkan menjadi 6 kelompok perlakuan, dengan perlakuan menaikkan jumlah katalis dan penambahan filler talc. Setiap kelompok perlakuan dilakukan pengulangan sebanyak 4 kali. Akurasi dimensi dari silikon RTV dilakukan pengecoran, dan diukur menggunakan dental caliper. Pengulangan dilakukan sebanyak 4 kali. Berdasarkan analisis data didapatkan tidak terdapat perbedaan rata-rata. Hasil: Hasil penelitian menunjukkan bahwa silikon RTV dengan PVS light body memiliki perbedaan yang nyata dengan nilai p<0.05. Pada akurasi dimensi antara kedua bahan silikon RTV dengan silikon PVS berviskositas light body impression, tidak memiliki perbedaan yang nyata dengan nilai p>0.05. Simpulan: RTV didapatkan rasio perbandingan yang paling optimal adalah katalis dan base (2:10) dengan penambahan filler talc sebanyak 10 gram. Pada akurasi dimensi silikon RTV dengan silikon berviskositas light body impression tidak memiliki perbedaan yang nyata/signifikan, sehingga kedua bahan memiliki keakuratan yang sama.KATA KUNCI: Silikon room temperature vulcanized (RTV), light body impression, akurasi dimensi 
Co-Authors Dudi Aripin Irsal, Imran Kambolong, Sitti Annisa Mardhian, Deby Fajar Masyhudi Masyhudi, Masyhudi Nina Djustiana Sulistiani, Dewi Arsih Verry Asfirizal Yohannes, Gabriel