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The effect of (3-aminopropyl) triethoxysilane and curcumin coating on the physicochemistry of Fe 3 O 4 particles as theranostics of oral cancer: qualitative study descriptive Yohannes, Gabriel; Djustiana, Nina; Mardhian, Deby Fajar; Sukotjo, Cortino; Aripin, Dudi
Padjadjaran Journal of Dental Researchers and Students Vol 7, No 3 (2023): Oktober 2023
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v7i3.48079

ABSTRACTIntroduction: Superparamagnetic iron oxide nanoparticles (SPION) has been used in MRI and have the capability to conjugate with different ligands. One of the active ingredients of interest in biomedical application is curcumin (Cur), which has been shown to have anti-inflammatory effect, wound healing property, and anti-cancer activity. However, such conjugation may need to be facilitated by polymer, such as 3-aminopropyltrimethoxysilane (AMPTS). This study aims to describe the effect of coating materials AMPTS and Cur on the physicochemistry of Fe3O4 particles as a diagnostic of oral cancer. Methods: Modified SPIONs were synthesized by a simple coprecipitation method. Fe3O4 particles were characterized using Fourier transform infrared spectroscopy (FTIR) to analyze the conjugation yield. Next, modified SPIONs were analyzed using dynamic light scattering (DLS) to examine size distribution. Furthermore, zeta potential of the particles was examined. Results: DLS showed size increases after modification of SPION with different materials. In addition, there were slight changes in zeta potential. However, FTIR showed no differences in peaks, indicating that no conjugation was successful. Conclusion: Although FTIR showed no differences in peaks, DLS and zeta potential showed changes with different coatings, which may indicate conjugation. However, further analyses must be carried out to quantify the conjugation yield.KEYWORDS: AMPTS, curcumin, iron oxide, oral cancer, coprecipitationPengaruh bahan pelapis AMPTS dan kurkumin terhadap fisikokimia partikel Fe3O4 sebagai teragnostik kanker mulut: studi deskriptifABSTRAKPendahuluan: Superparamagnetic iron oxide nanoparticle (SPION) telah digunakan dalam MRI dan memiliki kemampuan untuk dikonjugasi dengan berbagai ligan. Salah satu bahan aktif yang menjadi sorotan di bidang biomedis adalah curcumin yang memiliki sifat anti-inflamasi, penyembuhan luka, dan aktivitas anti-kanker. Akan tetapi, konjugasi tersebut biasanya memerlukan fasilitator berupa polimer, seperti 3-aminopropyltrimethoxysilane (AMPTS). Penelitian ini bertujuan untuk mendeskripsikan pengaruh bahan pelapis 3-aminopropyltrimethoxysilane (AMPTS) dan kurkumin (Cur) terhadap fisikokimia partikel Fe3O4 sebagai teragnostik kanker mulut. Metode: SPION disintesis dan dimodifikasi dengan bahan-bahan pelapis tersebut melalui metode kopresipitasi sederhana. Untuk menganalisis hasil konjugasi, sampel dikarakterisasi dengan fourier transform infrared spectroscopy (FTIR). Berikutnya, sampel dianalisis dengan dynamic light scattering (DLS) untuk melihat distribusi ukuran. Kemudian, potensial zeta sampel diukur. Hasil: DLS menunjukkan peningkatan ukuran setelah modifikasi SPION dengan bahan pelapis. Selain itu, ada perubahan dalam potensial zeta. Akan tetapi, analisis FTIR tidak menunjukkan perbedaan puncak serapan yang mengindikasikan ketiadaan konjugasi. Simpulan: Meskipun FTIR tidak menunjukkan perbedaan puncak serapan setiap sampel, DLS dan potensial zeta menunjukkan perubahan nilai untuk setiap sampel dengan coating berbeda, yang boleh jadi mengindikasikan konjugasi. Akan tetapi, analisis lebih lanjut perlu dilakukan untuk mengkuantifikasi konjugasi.KATA KUNCI: AMPTS, kurkumin, besi oksida, kanker mulut, kopresipitasi

Differences of room temperature vulcanized silicone and dimensional accuracy towards silicone PVS light body impression: Study experimental Kambolong, Sitti Annisa; Masyhudi, Masyhudi; Sulistiani, Dewi Arsih; Asfirizal, Verry; Irsal, Imran; Sukotjo, Cortino
Padjadjaran Journal of Dental Researchers and Students Vol 9, No 2 (2025): Juni 2025
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v9i2.62117

ABSTRAKIntroduction: Dental impressions are materials used to accurately replicate. Silicon Room Temperature Vulcanized (RTV) impression material is known to have good ultimate tensile strength and flexibility. Polyvinyl siloxane light body impression (low viscosity) which has the same viscosity as RTV material. Dimensional accuracy is used to see the accuracy of the impression material. Objective to investigate the optimal ratio of base, catalyst, and filler for RTV silicone to achieve the setting time and working time. To investigate is a difference between treatments using fillers and not using fillers. To investigate the difference in dimensional accuracy between the two materials. Methods: This research is pure experimental researches with randomized post-test only control group design. The control group was PVS light body silicone and the treatment group was RTV silicone. RTV silicones were categorized into 6 treatment groups. The treatments were increasing the amount of catalyst and adding talc filler. Each treatment group had 4 replications. Based on data analysis, there was no difference in the average. Results: The results showed that RTV silicone had significant difference with p < 0.05. At the ratio of RTV treatment groups without fillers by using fillers had a real difference with p < 0.05. In terms of dimensional accuracy, RTV silicone and silicone with light body impression viscosity did not have significant difference with p > 0.05. Conclusion: The optimal ratio for RTV silicon is 10:2 with the addition of 10 grams of talc filler. In the treatment using filler and without filler, having original fabrics with faster results was found in the filler treatment group. There is no significant difference in dimensional accuracy between RTV silicone and silicone with light body impression viscosity, so that both materials have the same accuracy.KEY WORDS: Room temperature vulcanized (RTV) silicone, light body impression, dimensional accuracyPerbandingan silikon room temperature vulcanized dan akurasi dimensi terhadap silikon PVS light body impression dalam kedokteran gigi : studi eksperimentalABSTRAKPendahuluan: cetakan gigi adalah bahan yang digunakan untuk membuat replika atau tiruan yang akurat. Bahan cetak Silicon Room Temperature Vulcanized (RTV) diketahui memiliki ultimate tensile strength serta kelenturan yang baik. Bahan polyvinyl siloxane (PVS) light body (viskositas rendah) yang memiliki viskositas sama dengan bahan RTV. Akurasi dimensi digunakan untuk melihat keakuratan bahan cetak. Metode: Penelitian ini bermetode eksperimental murni dengan desain penelitian Randomized post-test only control group design. Kelompok kontrol adalah Silikon PVS light body dan kelompok perlakuan adalah Silikon RTV. Silikon RTV dikelompokkan menjadi 6 kelompok perlakuan, dengan perlakuan menaikkan jumlah katalis dan penambahan filler talc. Setiap kelompok perlakuan dilakukan pengulangan sebanyak 4 kali. Akurasi dimensi dari silikon RTV dilakukan pengecoran, dan diukur menggunakan dental caliper. Pengulangan dilakukan sebanyak 4 kali. Berdasarkan analisis data didapatkan tidak terdapat perbedaan rata-rata. Hasil: Hasil penelitian menunjukkan bahwa silikon RTV dengan PVS light body memiliki perbedaan yang nyata dengan nilai p<0.05. Pada akurasi dimensi antara kedua bahan silikon RTV dengan silikon PVS berviskositas light body impression, tidak memiliki perbedaan yang nyata dengan nilai p>0.05. Simpulan: RTV didapatkan rasio perbandingan yang paling optimal adalah katalis dan base (2:10) dengan penambahan filler talc sebanyak 10 gram. Pada akurasi dimensi silikon RTV dengan silikon berviskositas light body impression tidak memiliki perbedaan yang nyata/signifikan, sehingga kedua bahan memiliki keakuratan yang sama.KATA KUNCI: Silikon room temperature vulcanized (RTV), light body impression, akurasi dimensi

Telemedicine in the management of temporomandibular disorders: A literature review Chairunnisa, Ricca; Shabrina, Aliyya; Sukotjo, Cortino
Dental Journal (Majalah Kedokteran Gigi) Vol. 57 No. 1 (2024): March
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i1.p68-73

Background: Temporomandibular disorders are clinical disorders involving the muscles of mastication, temporomandibular joints, and related structures. There are several treatments, such as self-help exercises, that can be done at home using remote care, often called telemedicine, after the patient has been directed to do so by a practitioner and evaluated during regular visits. Along with advancement of the times and technology, as well as with the prevention of COVID-19, telemedicine may currently be the main means of self-care for patients at home without losing the supervision of a doctor. Purpose: The purpose of this study is to determine the effect of using telemedicine in the management of temporomandibular disorders. Methods: A systematic literature review was undertaken using literature search methods in electronic databases: PubMed, ProQuest, and Google Scholar. The keywords were "(Telemedicine OR Teledentistry) AND (Temporomandibular disorder) AND (Effect).” The inclusion criteria for selection of the scientific articles were publication from 2012 to 2022, publication in English, and the full paper being available. Results: Seven articles have been included in this review. Based on the results of this systematic study, using telemedicine is considered able to assist the management of temporomandibular disorders by conducting consultation, follow-up, and treatment remotely via telephone, smartphone application, or internet-based or website-based applications. Conclusion: Telemedicine makes it easier for patients who do not have access to a health center to receive consultations and treatments from home, minimizing time and costs.

Penilaian densitas tulang alveolar sebelum perawatan implant menggunakan radiografi dental dan DEXA: a scoping review Pramanik, Farina; Jamaluddin, Rafiqah Rezky Amelia; Inayah, Rifarana; Wulansari, Daisy; Anggraini, Jamas Ari; Sukotjo, Cortino
Padjadjaran Journal of Dental Researchers and Students Vol 9, No 3 (2025): Oktober 2025
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v9i3.65953

ABSTRAKPendahuluan: Stabilitas implan sangat dipengaruhi oleh densitas tulang alveolar, dimana densitas tulang yang tinggi akan meningkatkan stabilitas primer implan dan mendukung osseointegrasi, sehingga evaluasi densitas tulang merupakan tahap yang penting sebelum dilakukan pembedahan. Pemeriksaan radiografi untuk evaluasi kualitas tulang merupakan prosedur yang penting dalam perencanaan sebelum pembedahan implan, oleh karena mudah didapatkan dan tidak bersifat invasif. Radiografi periapikal, panoramik dan CBCT merupakan teknik yang paling sering digunakan untuk mengevaluasi kualitas tulang pada perawatan implant. Sedangkan, DEXA merupakan metode gold standard untuk mengukur densitas mineral tulang. Jurnal ini bertujuan untuk menilai densitas tulang sebelum pemasangan implan, menggunakan radiografi periapikal, panoramik, CBCT dan DEXA. Metode: Scoping review ini menggunakan database seperti Science Direct, PubMed, PMC, Semantic Scholar, dan Google Scholar, menggunakan kata kunci: “Alveolar bone, density, presurgical, dental implant, and radiograph”. Pencarian mendapatkan 408 artikel, dan total 17 artikel yang digunakan pada jurnal ini. Hasil: Berbagai pemeriksaan radiografi dapat digunakan untuk mengevaluasi densitas tulang. Dari total 17 artikel, 7 artikel menggunakan CBCT, 2 panoramik, 3 DEXA, dan 3 menggabungkan 2 modalitas. Hasil penelitian menemukan bahwa mandibula, terutama pada anterior, memiliki densitas tulang yang lebih tinggi dibandingkan maksila. Dari berbagai artikel ini juga didapatkan beberapa perbedaan dalam teknik pengukuran, titik referensi, dan satuan (HU, g/cm³, mmAleq, GV). Simpulan: Pemeriksaan radiografi untuk mengukur densitas tulang alveolar merupakan teknik yang penting dalam menentukan rencana perawatan implant, dengan CBCT menjadi modalitas yang paling sering digunakan dan memberikan informasi yang paling banyak. Penelitian menunjukkan regio anterior mandibula memiliki densitas tulang yang paling tinggi di antara regio lainnya, sehingga mempengaruhi stabilitas implanKATA KUNCI: Densitas tulang alveolar, CBCT, DEXA, panoramik, periapikal, radiografiPre-implant assessment of alveolar bone density using dental radiographs and DEXA: a scoping review ABSTRACT Introduction: Implant stability is strongly influenced by alveolar bone density, as higher density enhances primary stability and supports long-term osseointegration, making its evaluation a crucial component in presurgical planning. Radiological assessment offers a readily available, non-invasive approach for evaluating bone quality prior to implant placement. Commonly used imaging modalities include periapical, panoramic, and cone-beam computed tomography (CBCT), while dual-energy X-ray absorptiometry (DEXA) remains the gold standard for measuring bone mineral density. This review aims to assess alveolar bone density before dental implant placement using periapical, panoramic, CBCT, and DEXA. Methods: A scoping review was conducted across Science Direct, PubMed, PMC, Semantic Scholar, and Google Scholar using the search terms “Alveolar bone, density, presurgical, dental implant, radiograph”. Inclusion and exclusion criteria were applied to 408 retrieved records, yielding 17 relevant articles for analysis. Results: Multiple radiographic methods and measurement protocols were identified. Of the 17 included studies, 7 utilized CBCT, 2 panoramic, 2 periapical, 3 DEXA, and 3 combined modalities. Findings indicated that the mandibular bone, particularly in the anterior region, generally exhibits higher density than the maxillary sites. Substantial variability was noted in measurement techniques, reference points, and units, including HU, g/cm³, mmAleq, and GV. Conclusion: Radiographic evaluation of alveolar bone density is essential for implant treatment planning. CBCT emerged as the most widely used and informative modality. Studies show that the anterior mandibular region has the highest bone density among other regions, thereby affecting implant stability.KEYWORDS: Alveolar bone density, CBCT, DEXA, panoramic, periapical, radiograph

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