Article Per Year (5 Year)
p-Index From 2021 - 2026
2.078
P-Index
This Author published in this journals
All Journal Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional Journal of Fundamental and Applied Pharmaceutical Science Sciences of Phytochemistry Journal of Tropical Pharmacy and Chemistry
Dahiru, Mubarak Muhammad
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 12 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 12 Documents
Search

 1   2 
Phytochemical Analysis and Antioxidant Potential of Ethylacetate Extract of Tamarindus Indica (Tamarind) Leaves by Frap Assay Dahiru, Mubarak Muhammad; Ahmadi, Hadiza; Faruk, Maimuna Umar; Hamman, Huzaifa Huzaifa Aminu; Charles, Abreme Gahana
Journal of Fundamental and Applied Pharmaceutical Science Vol. 3 No. 2 (2023): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i2.16708

Abstract

Oxidative stress is characterized by an imbalance in the generation of free radicals and their subsequent elimination by endogenous antioxidants. It is a characteristic of several diseases, especially during the progression stage, which can lead to fatal effects. This study aims to investigate the phytochemical components and antioxidant capability of Tamarindus indica and assess its capability as a candidate for managing diseases associated with oxidative stress. The gravimetric method detected and quantified phytochemicals, while the reducing power assay determined the antioxidant potential. Saponins, steroids, and flavonoids were detected in 6.83 ±0.44, 4.30 ±0.60, and 10.17% ±0.60, respectively, without alkaloids, glycosides, and terpenoids. The antioxidant test showed a concentration-dependent increase in absorbance of both the extract and standard (Ascorbic acid). However, Ascorbic acid had higher absorbance. At 100% concentration, the sample had an absorbance of 0.388 ±0.022, which was lower than the absorbance of Ascorbic acid (0.411 ±0.009) at 40% concentration. It can be concluded that Tamarind leaves could be utilized to manage diseases associated with oxidative stress, evidenced by their antioxidant potential credited to the phytochemical content of the leaves. However, there is a need for further studies to ascertain the exact compounds and their modes of action.
Antidiabetic Activity of Diospyros mespiliformis on Alloxan-Induced Diabetic Rats Dahiru, Mubarak Muhammad; Musa, Neksumi
Journal of Fundamental and Applied Pharmaceutical Science Vol. 5 No. 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.19798

Abstract

The rate of morbidity and mortality attributed to diabetes has become a concern and challenge for individuals and governments. The availability, affordability, and efficacy of plant-based drugs make them an attractive choice for diabetic management in low-income countries and rural communities. Thus, their application in folkloric medicine for diabetic management. This study investigated the antidiabetic activity of the crude ethanol extract (CRE), ethyl acetate (EAF), and aqueous (AQF) fractions Diospyros mespiliformis (DM) in alloxan-induced diabetic rats to justify its acclaimed applications in folkloric medicine. The effect of the plant extract and its fractions on the aspartate aminotransferase, glutamyl aminotransferase, albumin, urea, creatinine, electrolytes, and lipid profile was determined by biochemical assay methods. The result showed a significant (p < 0.05) decrease in fasting blood glucose for all the extracts, while the aspartate aminotransferase, gamma-glutamyl transferase, and albumin were significantly (p < 0.05) decreased in the EAF only. The urea and creatinine levels of the CRE and AQF were decreased significantly (p < 0.05), while K+, Cl-, and HCO3- levels decreased significantly (p < 0.05) for the treatment groups. Furthermore, a significant (p < 0.05) decrease in total cholesterol and triglyceride was observed for the EAF. Conclusively, DM exhibited significant hypoglycemic and hypolipidemic potential with improved lipid profile and hepato-renal function. Thus, the observed antidiabetic activity of the plant might justify its acclaimed utilization in the treatment/management of diabetes and its related ailment.    
Co-Authors Abaka, AbdulAzeez Mumsiri Abaka, AbudulAzeez Mumsiri Abdullahi, Tukur Baba Abdulllahi, Tukur Baba Abubakar, Aisha Abubakar, Keta Biman Ahmadi, Hadiza Alhaji, Aisha Alfa Alkasim, Hauwa Yahaya Artimas, Susan Pwakangdi Badgal, Enoch Buba Barau, Saminu Hamman Charles, Abreme Gahana Christopher, Patience Danga, James Fari, Ibrahim Ishaq Faruk, Maimuna Umar Gali, Ishaku Adamu Hamman, Huzaifa Huzaifa Aminu Hauwa, Alkasim Yahaya Ibe, Ifeanyi Jude Jonah, Faith Luka, Jordana Muhammad, Musa Muhammad, Zainab Musa, Neksumi Musa, Zuwaira Yusuf Oni, Abdulhasib Oluwatobi Peter, Rejoice Daniel Pius, Pwadumadi Umar, Abubakar Sadiq Waziri, Asma'u Abubakar Ya'u, Ibrahim Yakubu, Nuhu Dangana Zailani, Hauwa Ahmed Zainab, Muhammad Zira, Usanye Zoaka, Hesper Alex