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All Journal Pharmaciana: Jurnal Kefarmasian JURNAL PENDIDIKAN TAMBUSAI Amerta Nutrition SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Journal of Education and Culture Jurnal Pengabdian Masyarakat Dharma Andalas Sahabat Sosial: Jurnal Pengabdian Masyarakat
Dwinatrana, Khiky
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Penyuluhan Gangguan Saluran Cerna Kamal, Sefrianita; Serdiani, Serdiani; Surya, Sara; Putri, Lusia Eka; Fauzan, Adrul; Dwinatrana, Khiky; Usman, Hendrizal; Nofrizal, Nofrizal
Jurnal Pengabdian Masyarakat Dharma Andalas Vol 3 No 1 (2024): Jurnal Pengabdian Masyarakat Dharma Andalas
Publisher : LPPM Universitas Dharma Andalas

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Abstract

Counseling or counseling on gastrointestinal disorders by pharmacists can include a variety of services that focus on pharmaceutical aspects and drug management. Pharmacists play an important role in ensuring patients receive optimal pharmaceutical care in a home environment known as Home Care, in accordance with the Tri Dharma Perguruan Tinggi vision and mission of Universitas Dharma Andalas which makes its students Interpreneur. The purpose of this service is for students to be able to develop interpreneurship talents in themselves, with counseling and education techniques that will later become provisions when graduating into business opportunities and are able to create jobs. This counseling was carried out at SMK Kartika 1-2 and SMK Pratama Padang. It is hoped that through this counseling, students will be wise in managing their own health, especially those related to gastrointestinal disorders
Formulasi dan Uji Aktivitas Gel Hand Sanitizer Ekstrak Etanol Daging Buah Pala (Myristica Fragrans Houtt) dalam Menghambat Pertumbuhan Staphylococcus Aureus Usman, Hendrizal; Rustini, Rustini; Eka Putri, Lusia; Tri Andrica, Popy; Dwinatrana, Khiky
Journal of Education and Culture Vol. 4 No. 2 (2024): Journal of Education and Culture
Publisher : Indra institute Research & Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58707/jec.v4i2.853

Abstract

Membersihkan tangan adalah cara penting untuk menjaga kesehatan dan mencegah penyakit. Pembersih tangan berbasis alkohol semakin populer karena kemudahan akses dan efektivitasnya dalam mengurangi kuman, terutama di rumah sakit. Staphylococcus aureus, penyebab infeksi yang berasal dari komunitas dan nosokomial, menjadi tantangan klinis karena peningkatan resistensi antimikroba. Buah pala (Myristica fragrans Houtt) memiliki kandungan metabolit sekunder seperti sabinene, myristicin, elemicin, asam tetradekanoat, phellandrene, dan myrcene yang memiliki aktivitas antibakteri dengan spektrum luas. Penelitian ini bertujuan untuk membuat gel pembersih tangan yang mengandung ekstrak pala, efektif melawan S. aureus. Hasil penelitian ini menunjukkan bahwa sediaan Gel hand sanitizer ekstrak etanol daging buah pala menujukkan aktifitas sebagai antibakteri terhadap S.aureus dengan nilai rata-rata diameter zona hambat pada F1 sebesar (16.06±0.09) dan F2 sebesar (20.53±0.12). Gel hand sanitizer ekstrak daging buah Pala F1 dan F2, memiliki aktifitas antibakteri dengan kategori kuat dan sangat kuat terhadap bakteri S. aureus. Penggunaan bahan alami dalam hand sanitizer diketahui lebih aman, memiliki efek samping minimal, dan ramah lingkungan. Formulasi ini menawarkan solusi efektif dan berkelanjutan untuk kebersihan tangan.
Edukasi Penggunaan Antibiotik Dan Peduli Resistensi Antibiotik Pada Masyarakat Kota Padang Surya, Sara; Putri, Lusia Eka; Usman, Hendrizal; Nofrizal, Nofrizal; Dwinatrana, Khiky; Kamal, Sefrianita
Sahabat Sosial: Jurnal Pengabdian Masyarakat Vol. 2 No. 1 (2023): Sahabat Sosial: Jurnal Pengabdian Masyarakat (Desember)
Publisher : Asosiasi Guru dan Dosen Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59585/sosisabdimas.v2i1.244

Abstract

Antibiotics are drugs used to prevent and treat infections caused by bacteria. People mistakenly assume that antibiotics cure all diseases and are not careful in consuming or providing complete antibiotic therapy. Inappropriate use of antibiotics can increase medical costs because resistance makes the drugs more toxic. This Community Service activity aims to provide knowledge about the proper and correct use of antibiotics, providing knowledge about antibiotic resistance. This service activity is carried out by providing education and also providing leaflets about the use of antibiotics and antibiotic resistance. This activity was carried out by GOR H. Agus Salim, Padang City. The results of the activity where the number of participants was 80 people, there were still some who did not understand how to use drugs and antibiotic resistance. The activity was carried out by 6 lecturers assisted by 6 students from the Pharmacy Study Program at Dharma Andalas University. From this service activity, it is hoped that the people of Padang City will receive education about the use of antibiotics and be aware of the dangers of antibiotic resistance.
Enterobacter hormaechei: an endophytic bacterium found in Avocado Peel (Persea americana Mill.) with antioxidant properties Rustini, Rustini; Rahmi, Khalila Rahmi; Putra, Purnawan Pontana; Andayani, Regina Andayani; Dwinatrana, Khiky
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.28432

Abstract

Avocado peels (AVP) are renowned for their potent antioxidant properties, making them highly effective in preventing oxidation and free radical formation. Endophytes, microorganisms residing within plant tissues, have demonstrated the ability to produce novel compounds with remarkable biological activities. These bioactive compounds are sometimes even more potent than those found in their host plants. This study explores the potential of endophytes from avocado peels as rich sources of antioxidant compounds. AVP samples are collected, surface-sterilized, and segmented before being cultured in growth media. The bacteria are then isolated, purified, and subjected to ethyl acetate extraction to evaluate their antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) microassay. Samples demonstrating favorable antioxidant properties undergo molecular identification through 16S rRNA gene sequencing. Four bacterial strains are successfully isolated, with only the APK4 strain exhibiting significant antioxidant activity with an IC50 value of 302.3 μg/mL. Molecular analysis and phylogenetic tree construction reveal that APK4 is closely related to the Enterobacter hormaechei species, with a percent identity value of 99.93%. These findings highlight the potential of active metabolites from endophytic bacteria in AVP extracts as promising lead compounds for the development of novel drugs, nutraceuticals, and cosmetic ingredients.
Program Pemberian Tablet Fe di Sekolah dan Penurunan Kejadian Anemia pada Remaja Putri di Kota Padang: Program for Providing Iron Tablets in Schools and Reducing the Incidence of Anemia among Adolescent Girls in Padang City Asriyanti, Rita; Azrimaidaliza, Azrimaidaliza; Elda, Frima; Dwinatrana, Khiky
Amerta Nutrition Vol. 8 No. 3SP (2024): AMERTA NUTRITION SUPPLEMENTARY EDITION Special 4th Amerta Nutrition Conferenc
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v8i3SP.2024.162-169

Abstract

Background: Anemia among reproductive-age women can lead to significant nutritional issues for future generations. In Indonesia, the anemia prevalence rate among women is alarmingly high at 30.44%. A key strategy to reduce anemia is the distribution of iron tablets (Fe) in schools. Objectives: This study aimed to analyze the effectiveness of the iron tablet program in schools and its relationship to the incidence of anemia among adolescent girls in Padang City. Methods: A mixed-methods approach was utilized, combining quantitative and qualitative techniques. A cross-sectional design assessed the relationship between iron tablet distribution and anemia prevalence. Qualitative data were gathered through in-depth interviews to explore the program's implementation. The study involved two schools in Padang City, randomly selecting a sample of 274 adolescent girls. Data were collected using standardized instruments, analyzed with statistical software, and examined using multiple logistic regression tests. Results: The iron tablets program hasn’t been optimally implemented. The study found 28.1% of adolescent girls were anemic. An iron tablet consumption history (p-value=0.035), the quantity consumed (p-value=0.034), father's education level (p-value=0.039), and nutritional knowledge (p-value=0.032) related with anemic. Girls who did not consume iron tablets were 3.03 times more likely to be anemic. Many expressed concerns about the potential negative effects of iron tablets. Conclusions: This study reveals a troubling prevalence of anemia among adolescent girls, with nearly one-third affected. Inadequate iron tablet consumption, along with parental education and nutritional knowledge, significantly contributes to this issue. Concerns about side effects emphasize the urgent need for targeted educational interventions.
Pemanfaatan Jahe dan Pengolahannya untuk Kesehatan di SMA 1 pantai Cermin Surian Kamal, Sefrianita; Serdiani, Serdiani; Nofrizal, Nofrizal; Dwinatrana, Khiky; Azzahra, Rafifa; Anggia, Malse; Fitri, Widya; Sari, Dian Permata; Azura, Faradila; Cahyani, Dinda; Fajriani, Susi
Jurnal Pengabdian Masyarakat Dharma Andalas Vol 3 No 2 (2025): Jurnal Pengabdian Masyarakat Dharma Andalas
Publisher : LPPM Universitas Dharma Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47233/jpmda.v3i2.1953

Abstract

Plants from the Zingiberaceae family are the most commonly used in traditional medicine in Indonesia. Although modern medicine is rapidly developing in Indonesia, traditional medicine is still very often used in villages and cities. The part of the plant in the family member of the Zingiberaceae that is often used is its rhizoma which is distinctively aromatic and contains evaporated oil. This ginger has a lot of benefits, especially for health. Its antioxidant content can protect the body from free radicals and cell malignancy. Information about the benefits of this ginger plant was conveyed to the State High School 1 Pantai Cermin Surian, Solok Regency. This ginger plant can also be processed into an instant drink of ginger powder, On a visit to this school, a demonstration of making instant ginger was also carried out. It is hoped that through this service, students at SMA 1 Pantai Cermin can find out the benefits and how to process ginger.
Uji Aktivitas Inhibitor Enzim Xantin Oksidase Ekstrak Etil Asetat Jamur Endofit dari Kulit Buah Rambutan (Nephelium lappaceum L.) Dwinatrana, Khiky; Rustini, Rustini; Putri, Lusia Eka; Afriadi, Bayu; Surya, Sara; Usman, Hendrizal
Jurnal Pendidikan Tambusai Vol. 8 No. 3 (2024)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

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Abstract

Penyakit asam urat atau hiperurisemia sering kali dikaitkan dengan aktivitas enzim xantin oksidase (XO) yang berlebihan, sehingga penghambatan XO menjadi salah satu pendekatan terapi yang potensial. Rambutan (Nephelium lappaceum L.) merupakan buah tropis dari Asia Tenggara yang dikenal kaya akan metabolit sekunder seperti B-karoten, linoleat. Selain itu, jamur endofit, yang hidup dalam hubungan simbiosis dengan tanaman inangnya, memiliki kemampuan untuk menghasilkan penghambat enzim XO, yang berpotensi lebih kuat. Penelitian ini bertujuan untuk mengevaluasi potensi penghambatan XO dari ekstrak jamur endofit yang ditemukan pada kulit rambutan. Metode yang digunakan adalah uji in-vitro dengan microplate assay dengan enzim xantin oksidase. Xantin digunakan sebagai substrat dan allopurinol digunakan sebagai kontrol positif, sementara ekstrak etil asetat dari jamur endofit kulit rambutan diuji pada berbagai konsentrasi. Hasil penelitian menunjukkan bahwa ekstrak etil asetat dari jamur endofit kulit rambutan memiliki aktivitas penghambatan XO dengan nilai IC50 sebesar 116 dibandingkan dengan allopurinol sebesar 2,57.
Analisis Komparasi Pengaruh Anemia dan Kekurangan Energi Kronis Selama Kehamilan terhadap Berat Badan Lahir Rendah: Meta-Analisis: Comparative Impact of Maternal Anemia and Chronic Energy Deficiency on Low Birth Weight: Meta-Analysis Utami, Citra Tristi; Azrimaidaliza, Azrimaidaliza; Purnakarya, Idral; Dwinatrana, Khiky; Habibi, Nur Ahmad
Amerta Nutrition Vol. 9 No. 1SP (2025): AMERTA NUTRITION SUPPLEMENTARY EDITION Special 5th Amerta Nutrition Conferenc
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i1SP.2025.431-440

Abstract

Background: Low birth weight (LBW) remains a major public health problem, particularly in low- and middle-income countries. It contributes substantially to neonatal morbidity and mortality. Some of the risk factors for LBW are maternal anemia and chronic energy deficiency (CED). These conditions are common during pregnancy and preventable. Objectives: This study aimed to analyze the comparation between maternal anemia and chronic energy deficiency during pregnancy and the risk of low birth weight. Methods: A systematic search of PubMed and Scopus was conducted for studies published between January 2020 and July 2025. Of 1,121 records identified, 22 observational studies (case–control and cohort) met the inclusion criteria. Studies evaluating the association of maternal anemia or CED with LBW were included. Data were extracted independently by two reviewers. Meanwhile, data analysis involved multiple methods. For example, pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using meta-analytic models. Heterogeneity was assessed using the I² statistic, and publication bias was evaluated using funnel plots. This study’s protocol was registered in PROSPERO (CRD420251138329). Discussions: From 22 studies, 19 studies assessed maternal anemia (n = 16,219), and 11 studies assessed CED (n = 4,440). Maternal CED was associated with a nearly threefold increased risk of LBW (OR = 2.98; 95% CI: 2.07–4.29; I² = 82%), while maternal anemia increased the risk by 2.4 times (OR = 2.44; 95% CI: 1.73–3.43; I² = 86%). Funnel plots showed no substantial publication bias. Conclusions: Both maternal anemia and chronic energy deficiency are significantly associated with an increased risk of low birth weight, with CED demonstrating a stronger association. Strengthening antenatal nutritional interventions is essential to prevent LBW incidences.
Antibacterial Potential Of Endophytic Fungi Isolated From Pachyrhizus Erosus (Bengkoang) Dwinatrana, Khiky; Lira, Fadilla; Rustini, Rustini; Arif, Ferdian
SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Vol. 5 No. 1 (2026): SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Publisher : LPPM Akademi Farmasi Imam Bonjol Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62018/sitawa.v5i1.190

Abstract

The search for new antibacterial agents has increasingly focused on endophytic fungi, which inhabit plant tissues and may complement the bioactivity of their hosts. Pachyrhizus erosus (bengkoang), an edible legume rich in phenolics and flavonoids, remains underexplored as a reservoir of fungal endophytes with antibacterial potential. This study aimed to isolate endophytic fungi from P. erosus and evaluate their antibacterial properties. Tuber and leaf tissues were surface sterilized, yielding five isolates (PE1–PE5) that were cultured on rice medium, extracted with ethyl acetate, and tested against Staphylococcus aureus ATCC 29213 and Escherichia coli ATCC 25922 using the Kirby–Bauer disc diffusion method. All extracts inhibited bacterial growth, with PE2 showing the strongest activity (15.7 ± 1.40 mm for S. aureus and 14.4 ± 0.32 mm for E. coli). TLC profiling of PE2 extract revealed multiple spots under UV (254 and 366 nm), and phytochemical screening indicated the presence of phenolics and triterpenoids. Taken together, the results demonstrate that tuber-associated endophytic fungi of P. erosus are capable of producing antibacterial metabolites comparable to plant-derived compounds, underscoring their potential as sources of antimicrobial agents.
Co-Authors AA Sudharmawan, AA Afriadi, Bayu Andayani, Regina Andayani Arif, Ferdian Asriyanti, Rita Azrimaidaliza Azura, Faradila Azzahra, Rafifa Cahyani, Dinda Dian Permata Sari Eka Putri, Lusia Fajriani, Susi Fauzan, Adrul Fitri, Widya Frima Elda Idral Purnakarya Kamal, Sefrianita Lira, Fadilla Malse Anggia Nofrizal Nofrizal Nofrizal Nur Ahmad Habibi Putri, Lusia Eka Rahmi, Khalila Rahmi Rustini Rustini Serdiani, Serdiani Surya, Sara Tri Andrica, Popy Usman, Hendrizal Utami, Citra Tristi