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All Journal Journal of Biomedicine and Translational Research Jurnal Media Gizi Indonesia (MGI)
Bintang, Francisca Natalia
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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Sorghum Tempeh on Cholesterol Levels and Histopathology of Aorta in High-Fat Diet-Induced Rat Model Bintang, Francisca Natalia; Lestari, Endang Sri; Afifah, Diana Nur; Muniroh, Muflihatul; Anjani, Gemala; Syauqy, Ahmad; Djamiatun, Kis
Journal of Biomedicine and Translational Research Vol 10, No 2 (2024): August 2024
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v10i2.22689

Abstract

Background: Elevated cholesterol levels are associated with hypercholesterolemia, the primary cause of death and lost productivity, and a significant risk factor for the onset of cardiovascular disease. Sorghum is known for its high bioactive components and phenolic compounds, flavonoids, β-glucans, and dietary fiber, which act as anti-cholesterol properties.Objective: This study aimed to analyze the impact of sorghum tempeh on cholesterol levels and histopathology of aorta in rats fed a high-fat diet.Methods: A total of 24 male 8-weeks-old Sprague Dawley rats were randomly assigned to four groups: standard diet group (SD), high-fat diet control group (FD), rats fed high-fat diet + low dose of sorghum tempeh (T1), and high-fat diet + high dose of sorghum tempeh (T2). Measurements of cholesterol levels were determined using the total cholesterol ELISA method. Histopathology of aorta analysis was carried out after four weeks of intervention of the four treatment groups using Hematoxylin-Eosin staining.Results: The average total cholesterol levels post-intervention in the SD, FD, T1, and T2 were 89.986±2.089, 220.365±3.847, 121.161±4.111, and 97.836±2.504 mg/dL, respectively. The results showed that the total cholesterol level significantly decreased (p<0.05) after giving a formula of sorghum tempeh with doses of 0.75 g and 1.50 g per 200 g body weight of rats for four continuous weeks. Histopathology of the aorta in the FD and T2 groups showed a significant difference compared to the SD group. The result which was closest to the SD group was the T1 group.Conclusion: Sorghum tempeh is a high-fiber and antioxidant source that can control hypercholesterolemia by lowering serum total cholesterol. It is also possible to improve histopathology but not yet able to approach normal conditions. The administration of sorghum tempeh with a low dose is sufficient, and further research is still required to determine the effect of sorghum tempeh on aorta histopathology.
Sorghum Tempeh Enteral Formula Reduces Inflammatory (IL-6) and Thrombotic (PAI-1) Markers in Atherogenic Diet-Induced Rats Bintang, Francisca Natalia; Resti, Nina; Lestari, Endang Sri; Muniroh, Muflihatul; Anjani, Gemala; Syauqy, Ahmad; Djamiatun, Kis; Afifah, Diana Nur
Media Gizi Indonesia Vol. 21 No. 2 (2026): MEDIA GIZI INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v21i2.185-195

Abstract

Atherosclerosis is predominantly an inflammatory process that is the key pathophysiological cause of ischemic coronary heart disease (CHD). Some studies suggest that sorghum can reduce atherosclerotic parameters through many biological activities, such as antioxidant, anti-inflammation, and anti-thrombotic properties. The primary objective was to evaluate the effect of an enteral sorghum tempeh formula on the levels of Plasminogen Activator Inhibitor-1 (PAI-1) and Interleukin-6 (IL-6) in an atherosclerotic rat model. A total of 24 male rats were utilized, with the experiment structured into an 8-week atherogenic diet induction period, followed by a 4-week intervention phase. The rats were divided into four groups: a healthy control, an atherogenic control, and two treatment groups supplemented with the formula at 0.75g/200 g and 1.50g/200 g body weight (BW), respectively. IL-6 and PAI-1 levels were quantified using Enzyme-Linked Immunosorbent Assay (ELISA). The atherogenic diet successfully induced a significant elevation in both IL-6 and PAI-1 levels compared to the healthy control group (p=0.000), indicating a heightened inflammatory and thrombotic state in the atherosclerotic group. Conversely, the groups receiving the sorghum tempeh-based formula exhibited a significant reduction in both IL-6 and PAI-1 levels compared to the atherogenic control group (p=0.000), suggesting potent anti-inflammatory and antithrombotic properties of the sorghum tempeh.
Co-Authors Ahmad Syauqy Anjani, Gemala Diana Nur Afifah, Diana Nur Endang Sri Lestari Kis Djamiatun Muniroh, Muflihatul Resti, Nina