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All Journal Jurnal Ilmiah Farmasi Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Ahmad Dahlan Medical Journal
Purwanto, Barkah Djaka
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Management of Sodium Imbalance Purwanto, Barkah Djaka; Perdana Putri, Rachma Greta
Ahmad Dahlan Medical Journal Vol. 5 No. 1 (2024): May 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sodium imbalance consists of hyponatremia and hypernatremia. Acute and severe hyponatremia and hypernatremia are life-threatening conditions. Rapid and slow correction should be considered for optimal outcomes, as aggressive management is often associated with the danger of demyelination and cerebral edema. This review aims to determine the safe management of sodium imbalance so that it is hoped that in overcoming critical conditions it does not transfer to other critical conditions that are equally fatal. The data search strategy uses the PubMed and Google Scholar databases between 2010 and 2022 with free full text that can be downloaded. The findings emphasize that acute and severe hyponatremia and hypernatremia are often life-threatening conditions. Management of these conditions requires caution, as aggressive correction in hyponatremia can result in osmotic demyelination, while hypernatremia can lead to cerebral edema. Despite theoretical risks, the study found no significant difference in 30-day mortality, seizures, cerebral edema, or decreased consciousness between fast and slow correction methods. The conclusion underscores the importance of tailored and cautious management strategies to mitigate the risks associated with sodium imbalance corrections.
Quality of Life and Costs of Illness of Dengue Patients at Pku Muhammadiyah Yogyakarta and Bantul Boisi, Cici Feronika; Purwanto, Barkah Djaka; Supadmi, Woro; Faridah, Imaniar Noor; Perwitasari, Dyah Aryani
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art5

Abstract

Background: The manifestation of dengue is a decrease in hematocrit and platelet levels, leading to a decrease in the patient’s quality of life and having an impact on the patient’s medical costs.Objective: This study objective was to ascertain the quality of life and medical costs associated with dengue patients.Method: This study employed a cross-sectional design at PKU Muhammadiyah Hospitals in Bantul and Yogyakarta from January to August in 2023. Pediatric patients’ quality of life was assessed using the EQ-5D-Y questionnaire, while adult patients’ using the EQ-5D-5L questionnaire. Data on patients’ medical costs was obtained from the hospital's financial database. The data were then analyzed descriptively and presented as a percentage of quality of life and average medical costs.Results: The results showed that pediatric DF patients in both hospitals reported anxiety and depression, with percentages of 100% (Yogyakarta) and 75% (Bantul), respectively. Meanwhile, most adult DF patients experienced problems in carrying out routines, 71.4% (Yogyakarta) and 50% (Bantul), respectively. Adult DHF patients in both hospitals reported pain and discomfort of 66.7% (Yogyakarta) and 100% (Bantul), respectively. The highest average medical costs paid by DF and DHF patients at PKU Jogja Hospital were IDR 4,919,450 and IDR 6,981,500. DF and DHF patients at PKU Hospital with BPJS insurance, with the highest average medical costs of IDR 2,726,245.5 (for DF patients) and IDR 4,797,700 (for DHF patients) to cover for laboratory costs.Conclusion: Dengue fever infections are impacting the patient's quality of life and medical costs.
Patterns of High-Alert Medicine Use in Geriatric Patients at Rumah Sakit Umum Pusat Dr. Cipto Mangunkusumo Malihi, La; Supadmi, Woro; Trisna, Yuliana; Purwanto, Barkah Djaka
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.97181

Abstract

Background: Geriatric patients are patients who are often associated with multiple diseases and decreased organ function so they are at greater risk of developing unwanted drug reactions due to drug use when compared to other adults. High Alert Medication (HAM) are drugs that have a high risk of causing significant harm to patients if used incorrectly.Objectives: This study aims to determine the pattern of HAM use among inpatient geriatric patients at Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo Jakarta.Methods: Retrospective cohort study by reviewing primary data from medical records (MR) of inpatient geriatric patients who used HAM for the period January 1 to December 31, 2023. The sample consisted of 300 geriatric patients who met the inclusion criteria using a purposive sampling technique. Descriptive data analysis includes data in the form of frequencies and percentages (%).Results: Based on gender, women with a total of 162 (54%) patients dominated. Based on age, the age range of 60 to 70 years with a total of 104 (68.87%) patients with a diagnosis of hypertension dominated compared to other ages. Based on the type of HAM used namely Insulin group HAM with 53 (20.38%) times of administration with the type of insulin in the form of novorapid flexpen 3 ml (13,532%) and anticoagulant group HAM with 49 (18,84%) times of administration with the type of anticoagulant in the form of heparin sodium 5 ml (13,181%) with the diagnosis of hypertension.Conclusion: The types of HAM that dominate the use in the therapy of hospitalized geriatric patients are novorapid flexpen 3 ml and heparin sodium 5 ml given parenterally with a diagnosis of hypertension.
Mapping rheumatoid arthritis susceptibility through integrative bioinformatics and genomics Medi Sushanti, Nining; Adikusuma, Wirawan; Afief, Arief Rahman; La’ah, Anita Silas; Firdayani, Firdayani; Chong, Rockie; Zakaria, Zainul Amiruddin; Purwanto, Barkah Djaka; Satria, Rahmat Dani; Khair, Riat; Septama, Abdi Wira; Irham, Lalu Muhammad
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.24912

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease that influences several organs and tissues, especially the synovial joints, and is associated with multiple genetic and environmental factors. Numerous databases provide information on the relationship between a specific gene and the disease pathogenesis. However, it is important to further prioritize biological risk genes for downstream development and validation.  This study aims to map RA-association genetic variation using genome-wide association study (GWAS) databases and prioritize influential genes in RA pathogenesis based on functional annotations. These functional annotations include missense/nonsense mutations, cis-expression quantitative trait locus (cis-eQTL), overlap knockout mouse phenotype (KMP), protein-protein interaction (PPI), molecular pathway analysis (MPA), and primary immunodeficiency (PID). 119 genetic variants mapped had a potential high risk for RA based on functional scoring. The top eight risk genes of RA are TYK2 and IFNGR2, followed by TNFRSF1A, IL12RB1 and CD40, C5, NCF2, and IL6R. These candidate genes are potential biomarkers for RA that can aid drug discovery and disease diagnosis.
Co-Authors Abdi Wira Septama Afief, Arief Rahman Boisi, Cici Feronika Chong, Rockie Dyah Aryani Perwitasari Firdayani, Firdayani Imaniar Noor Faridah Khair, Riat Lalu Muhammad Irham La’ah, Anita Silas Malihi, La Medi Sushanti, Nining Perdana Putri, Rachma Greta Satria, Rahmat Dani Trisna, Yuliana Wirawan Adikusuma Woro Supadmi Zakaria, Zainul Amiruddin