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Factors that Influence the Level of Medication Adherence in Diabetes Mellitus Patients in Magelang City Hospital Kemila, Mira; Astyamalia, Suzan
Jurnal Ilmu Kesehatan Vol 12 No 1 (2024): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

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Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormalities in insulin secretion, insulin action or both. Treatment adherence and low glycemic control are still problems in the majority of DM patients. Non-compliance of type 2 diabetes mellitus patients with treatment will have an impact on expected clinical outcomes, risk of complications, and poor quality of life. Therefore, this study aims to determine the level of compliance of diabetes mellitus patients and analyze the factors that influence it. This study is an analytical study observational with a cross sectional design and carried out at the Internal Medicine Clinic, Magelang City Regional Hospital from December 2023 to January 2024. The sample for this study is diabetes mellitus patients who are taking antidiabetic drugs at the Internal Medicine Clinic, Magelang Regional Hospital. The research instrument is a questionnaire from Morisky Medication Adherence Scale 8-item (MMAS-8). Bivariate data analysis using tests chisquare using SPSS. Effects were considered significant if p < 0.05. Level of adherence to treatment long-term oral antidiabetic in the majority of DM patients are in the Disease Polyclinic In the Magelang City Regional Hospital it is still moderate. This study shows that The amount of medication consumed in a day is factors that have the most influence on level of treatment compliance. Meanwhile, age, gender, occupation and length of suffering DM has no effect on level patient compliance in treatment

Edukasi pencegahan hipertensi dan pengetahuan minum obat di lingkungan Pemuda Muhammadiyah Ngaglik Astyamalia, Suzan; Kemila, Mira
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 6 No. 1 (2025): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/indra.v6i1.382

Hypertension is included in top ten diseases in Sleman Regency 2023 for all age groups. Men have a risk 3 times greater than women. There is a significant relationship between the level of knowledge and adherence to taking medication in hypertensive patients. Therefore, it is necessary to provide services in the form of education regarding the prevention of hypertension and knowledge regarding adherence to taking antihypertensive medication among young people in Sleman. The service was carried out in Sleman Regency with 20 Muhammadiyah youth from Sleman Regency as participants. The service instrument used is a questionnaire. The data was analyzed by classifying the level of education and assessing the percentage of knowledge level of the respondents' answers, which was 50% good, 40% sufficient and 10% less. The results concluded that education had a good impact on the level of knowledge for some respondents.

Factors that Influence the Level of Medication Adherence in Diabetes Mellitus Patients in Magelang City Hospital Kemila, Mira; Astyamalia, Suzan
Jurnal Ilmu Kesehatan Vol 12 No 1 (2024): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormalities in insulin secretion, insulin action or both. Treatment adherence and low glycemic control are still problems in the majority of DM patients. Non-compliance of type 2 diabetes mellitus patients with treatment will have an impact on expected clinical outcomes, risk of complications, and poor quality of life. Therefore, this study aims to determine the level of compliance of diabetes mellitus patients and analyze the factors that influence it. This study is an analytical study observational with a cross sectional design and carried out at the Internal Medicine Clinic, Magelang City Regional Hospital from December 2023 to January 2024. The sample for this study is diabetes mellitus patients who are taking antidiabetic drugs at the Internal Medicine Clinic, Magelang Regional Hospital. The research instrument is a questionnaire from Morisky Medication Adherence Scale 8-item (MMAS-8). Bivariate data analysis using tests chisquare using SPSS. Effects were considered significant if p < 0.05. Level of adherence to treatment long-term oral antidiabetic in the majority of DM patients are in the Disease Polyclinic In the Magelang City Regional Hospital it is still moderate. This study shows that The amount of medication consumed in a day is factors that have the most influence on level of treatment compliance. Meanwhile, age, gender, occupation and length of suffering DM has no effect on level patient compliance in treatment

Formulasi dan Karakterisasi Nanopartikel Ekstrak Biji Carica (Carica pubescens) dengan Variasi Konsentrasi Kitosan menggunakan Metode Gelasi Ionik Luhurningtyas, Fania Putri; Damayanti, Prashinta Nita; Astyamalia, Suzan; Kemila, Mir-a; Novitasari, Evi
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.39161

Carica seeds (Carica pubescens) contain alkaloid, saponin, and flavonoid compounds, which have pharmacological activities such as antibacterial, anti-inflammatory, immunomodulatory, and antihyperlipidemic properties, but their bioavailability is low. Nanotechnology has significantly advanced in drug delivery systems because it can enhance absorption in the gastrointestinal tract, allowing entry into the bloodstream. This study aims to create and evaluate the characteristics of carica seed extract nanoparticles with varying concentrations of chitosan. The carica seed extract was obtained using the maceration method with 70% ethanol as the solvent. The Carica seed extract was then formulated into nanoparticles using the ionic gelation method with varying concentrations of chitosan: NaTPP, specifically formulas FA (0.3:1), FB (0.2:1), and FC (0.1:1). The resulting nanoparticle colloids were characterized for particle size, polydispersity index (PDI), percent transmittance (%T), and specific functional groups. The results showed that the particle sizes for formulas FA, FB, and FC were 243.7 nm, 47.96 nm, and 116.6 nm, respectively. The PDI values for formulas FA, FB, and FC were 0.378, 0.357, and 0.52, respectively. The percent transmittance for all three formulas ranged from 99.5% to 99.6%. The characterization of functional groups indicated interactions between the carica seed extract, chitosan, and NaTPP, with the presence of OH, N-H, aliphatic CH, P=O, and PO3 groups. These interactions were observed based on the shift in wavenumbers in the FTIR results for each sample. All carica seed nanoparticle formulas showed particle sizes within the nanometer range (<1000 nm), polydispersity indices less than 1, percent transmittance close to 100%, and specific functional groups indicating interactions between the extract and the coating polymer. Formula FB was the optimal formula, with the smallest nanoparticle size (<100 nm), a PDI value of <0.5, and a percent transmittance of >99%.

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