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Penerapan DNA Rekombinan Dalam Terapi Gen Ardandi, Rofi Yoga; Nurhaliza, Suci; Poty, Pitha Maykania; Sha, Nindy Putri; Rahmanisa, Soraya
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.930

Abstract

Recombinant DNA technology is the fusion of genetic material from two different sources. Recombinant DNA refers to combining genetic material from two different sources to create a new organism or to produce a specific protein. The main purpose of genetic recombination is to produce more evolved and adapted organisms, as well as develop biotechnology strategies, such as recombinant protein production. This technology is applied in clinical and medicine such as vaccines. Recombinant vaccines are made by utilizing recombinant DNA technology, which is a gene cloning technique that is modified to produce the specific protein product sought. Gene cloning is a procedure by which foreign DNA or genes are inserted into a host cell using a vector. Gene cloning involves the insertion of a gene of interest into a vector, resulting in the creation of recombinant DNA that can replicate within the host cell, an example being the SARS-CoV-2 DNA vaccine. Oncolytic virus, Gendicine, Modified Virus Ankara (MVA) are recombinant DNA technologies for cancer therapy. The advantages of this therapy are its ability to form new combinations of genetic material by insertion of molecules; DNA recombination technology allows the production of large quantities of certain protein molecules, which can be used in the manufacture of drugs; the production of therapeutic substances by strains of organisms can be achieved through the use of recombinant DNA technology; drugs that have unique properties that are difficult or impossible to obtain through traditional approaches can be made through DNA recombination; and DNA recombination plays an important role in drug manufacturing by facilitating the synthesis of therapeutic molecules important for human health. The disadvantages are that it has a negative impact on the environment, requires strict supervision to ensure safety and security, and ethical controversies. This technology has many benefits, but it is necessary to consider some of the disadvantages and adverse effects that can be caused.
Pengelolaan Potensi Bahaya dan Risiko Kerja pada Pekerja Kampung Maggot Bandar Lampung Berawi, Khairun Nisa; Karima, Nisa; Zahra, Tsurayya Fathma; Siregar, Maulana Irfan Hazairin; Safira, Ditya Ananda; Nurhaliza, Suci; Rahmah, Azizah Nur; Padmadisastra, Jauzaa Faishal Ahmad; Shiddiq, Haikal; Christy, Angelica Philia; Murfi, Syahrani Alya
Poltekita: Jurnal Pengabdian Masyarakat Vol. 4 No. 4 (2023): Oktober - Desember
Publisher : Pusat Penelitian & Pengabdian Masyarakat Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/pjpm.v4i4.2801

Abstract

Kampoeng Maggot is a subsidiary of Green Gunter Farm which operates in the livestock and fisheries sector which focuses on the BSF (Black Soldier Fly) maggot cultivation sector. The aim of this PKM is to identify potential hazards at Green Gunter Farm and increase workers' understanding of the importance of protective equipment and work compliance by providing interventions to control these potential hazards. The PKM method is carried out by identifying potential hazards and intervention in the form of counseling and creating work SOPs. The identification results show that the greatest risk of work hazards comes from potential ergonomic hazards due to the uneven terrain. Apart from that, workers are also not used to using complete personal protective equipment due to the lack of adequate SOPs. PKM results show an increase in workers' knowledge and attitudes about personal hygiene, PPE, and the work environment, as well as the availability of SOPs that guide safe work flows to minimize potential hazards and work risks.