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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Health Information : Jurnal Penelitian Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Pake, Indry Agatha Rihi
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Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Risk Prediction Acute Kidney Injury Pada Pasien Sepsis Elhapidi, Nafisa Zulpa; Kalew, Priska Amanda; Darmadji, Edlin Gisela; Pake, Indry Agatha Rihi; Regina, Sheren
Health Information : Jurnal Penelitian Content Digitized
Publisher : Poltekkes Kemenkes Kendari

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Abstract

Sepsis merupakan kondisi disfungsi organ yang disebabkan oleh terganggunya respon inflamasi tubuh dalam mengatasi infeksi. Acute kidney injury (AKI) merupakan keadaan penurunan laju filtrasi glomerulus (LFG) secara tiba-tiba selama ? 7 hari, peningkatan kreatinin serum ?0.3 mg/dL dalam 48 jam atau peningkatan kreatinin serum ?1.5 kali dari nilai awal dalam 7 hari atau volume urin <0.5 mL/kgBB/jam selama 6 jam. Sepsis-associated acute kidney injury (S-AKI) adalah komplikasi yang umumnya terjadi pada pasien sepsis yang dirawat dan meningkatkan risiko perburukan penyakit dan risiko mortalitas. Beberapa faktor risiko dikatikan dengan terjadinya S-AKI tetapi faktor risiko secara lengkap belum sepenuhnya diketahui. Tujuan penelitian ini adalah untuk mengetahui faktor risiko terjadinya S-AKI. Desain penelitian yang digunakan adalah tinjauan pustaka terkait faktor risiko terjadinya AKI pada pasien sepsis. Sumber pustaka diperoleh dari Pubmed, Google Scholar, ScienceDirect, Ebsco dan Hindawi yang dipublikasikan dalam 5 tahun terakhir. Secara keseluruhan faktor risiko terjadinya AKI pada pasien sepsis adalah jenis kelamin, ras, riwayat gagal jantung, diabetes, obesitas, penggunaan Angiotensin-converting enzyme inhibitors (ACEI) atau angiotensin II receptor blockers (ARB), bilirubin, kreatinin, blood urea nitrogen (BUN) dan ventilasi mekanik. S-AKI merupakan komplikasi yang umum terjadi pada pasien sepsis. Faktok risiko S-AKI harus dinilai sejak dini untuk mengurangi risiko mortalitas.
Pengaruh Suplementasi Probiotik terhadap Luaran Pengobatan Pasien dengan Tuberkulosis Aktif: Sebuah Kajian Sistematis Pake, Indry Agatha Rihi; Abdullah, Hafidz; Fahreza, Lufthi; Suwandi, Jeremiah; Faisal, Zuresh Shafira Sharafina; Karidza, Bilqish; Lazarus, Gilbert
Majalah Kedokteran Indonesia Vol 75 No 1 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.1-2025-1390

Abstract

Introduction: Tuberculosis, one of the most globally burdensome infectious diseases, poses high mortality and morbidity risks due to the adverse effects of treatment and disease-related complications, resulting in poor treatment adherence. Despite probiotics, treatment supplements containing live bacteria and having known immunomodulatory effects, their impact on tuberculosis therapy remains understudied. Hence, this systematic review aims to explore the effect of probiotic supplementation on the outcomes of active tuberculosis therapy, including but not limited to its effectiveness in improving tuberculosis treatment and host immunity, as well as its adverse events. Method: A systematic review was performed by searching relevant primary clinical studies from PubMed, Embase, Google Scholar, and Clinicaltrials.gov. The included studies were assessed for risk of bias with the Revised Cochrane risk-of-bias tool for randomized trials, and the findings were synthesized qualitatively. Results: A total of five randomized controlled trials involving 926 patients were included in this systematic review. Our findings revealed that Lactobacillus casei probiotic supplementation significantly reduced the incidence and duration of gastrointestinal side effects during tuberculosis therapy, particularly vomiting, decreased appetite, and constipation. Additionally, probiotics displayed the potential to enhance immunity by increasing lymphocyte cell counts, downregulating proinflammatory cytokines, maintaining immunoglobulin A levels in saliva, mitigating oxidative stress in gastrointestinal organs, and ameliorating gut dysbiosis. Conclusion: These results highlight the advantageous impact of probiotics on active tuberculosis therapy outcomes. Further studies involving a more heterogeneous population investigating the adverse effects following probiotics use, and the long-term effects of probiotics supplementation are required to substantiate our findings.
Determinant Factors of Type 2 Diabetes Mellitus Among Older Adults in Kelating Village Pake, Indry Agatha Rihi; Putra, I Made Gede Dwipayana; Adrya, Jessica; Jayaningrat, Dewa Ayu Tri; Wirawan, I Made Suma
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i2.57738

Abstract

Type 2 diabetes mellitus (DM) increased in the elderly population due to metabolic changes and decreased function of pancreatic β cells. This study aims to determine the prevalence of type 2 diabetes mellitus in the elderly and examine the risk factors—such as age, gender, blood pressure, and uric acid levels—that influence the incidence of type 2 DM. This cross-sectional study involved 31 elderly people (≥60 years) in Segara Santhi, Kelating Village, Tabanan, who were selected using purposive random sampling. Fasting blood glucose and uric acid levels were checked using Accu-Chek after fasting for at least 8 hours. Data analysis used the Fisher's Exact Test with a significance of p<0.05. The results show prevalence of type 2 DM was 64.5% (20 of 31 respondents). Age and type 2 DM had no significant association (p= 0.262). However, there was a significant association between type 2 DM and gender (p = 0.012) and uric acid levels (p = 0.029), but not with blood pressure (p = 1,000). The prevalence of type 2 DM in the elderly in Segara Santhi is quite high, but age is not the main factor. Other factors such as diet, physical activity, and genetic predisposition may play a greater role. Further studies with larger sample sizes and multivariate analysis are needed to understand the risk factors for type 2 DM in the elderly more specifically.
Co-Authors Abdullah, Hafidz Adrya, Jessica Darmadji, Edlin Gisela Elhapidi, Nafisa Zulpa Fahreza, Lufthi Faisal, Zuresh Shafira Sharafina Jayaningrat, Dewa Ayu Tri Kalew, Priska Amanda Karidza, Bilqish Lazarus, Gilbert Putra, I Made Gede Dwipayana Regina, Sheren Suwandi, Jeremiah Wirawan, I Made Suma