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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Medicinus : Jurnal Kedokteran
Adrya, Jessica
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Humanities Education Environmental Science Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Determinant Factors of Type 2 Diabetes Mellitus Among Older Adults in Kelating Village Pake, Indry Agatha Rihi; Putra, I Made Gede Dwipayana; Adrya, Jessica; Jayaningrat, Dewa Ayu Tri; Wirawan, I Made Suma
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i2.57738

Abstract

Type 2 diabetes mellitus (DM) increased in the elderly population due to metabolic changes and decreased function of pancreatic β cells. This study aims to determine the prevalence of type 2 diabetes mellitus in the elderly and examine the risk factors—such as age, gender, blood pressure, and uric acid levels—that influence the incidence of type 2 DM. This cross-sectional study involved 31 elderly people (≥60 years) in Segara Santhi, Kelating Village, Tabanan, who were selected using purposive random sampling. Fasting blood glucose and uric acid levels were checked using Accu-Chek after fasting for at least 8 hours. Data analysis used the Fisher's Exact Test with a significance of p<0.05. The results show prevalence of type 2 DM was 64.5% (20 of 31 respondents). Age and type 2 DM had no significant association (p= 0.262). However, there was a significant association between type 2 DM and gender (p = 0.012) and uric acid levels (p = 0.029), but not with blood pressure (p = 1,000). The prevalence of type 2 DM in the elderly in Segara Santhi is quite high, but age is not the main factor. Other factors such as diet, physical activity, and genetic predisposition may play a greater role. Further studies with larger sample sizes and multivariate analysis are needed to understand the risk factors for type 2 DM in the elderly more specifically.
Investigating the Prognostic Value of Serum Albumin Levels in Patients Undergoing Hemodialysis: A Systematic Review and Meta-analysis Adrya, Jessica; Sasongko, Calvin; Andrean, Melvin; Kartadinata, Muhammad Faishal; Theis, Aveline Maisie; Putri, Syafira Ayudiah Syah; Mukti, A. Muh. Yasser; Moelyadi, Felly; Varsha, Srigita; Dhika, Veriantara Satya
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10770

Abstract

Background: Hypoalbuminemia, characterized by low serum albumin levels, is frequently observed in patients undergoing hemodialysis and has been identified as a potential predictor of increased mortality risk. This systematic review aims to evaluate the relationship between hypoalbuminemia and mortality in hemodialysis patients, assessing the prognostic value of serum albumin levels as an indicator for patient outcomes. Methods: A comprehensive search was conducted in databases including PubMed, Europe PMC, and Scopus to identify relevant studies. Studies were included if they investigated the association between serum albumin levels and mortality outcomes in adult patients undergoing hemodialysis. Data extraction was performed independently by two reviewers, focusing on study characteristics, patient demographics, albumin levels, and mortality outcomes. Quality assessment of studies was conducted using the Newcastle-Ottawa Scale (NOS). Result: A total of eight studies, encompassing 45,178 hemodialysis patients with a mean age in the 50s, met the inclusion criteria. The studies had a combined male cohort of 22,501 individuals. The definition of hypoalbuminemia varied across studies, with cutoff values ranging from 3.0 to 3.9 g/dL. Follow-up durations spanned from as early as 3 months to a maximum of 6.1 years. The meta-analysis revealed a pooled hazard ratio (HR) of 1.08 (95% CI: 0.94–1.25), suggesting a non-significant association between hypoalbuminemia and increased mortality risk (P = 0.28). However, substantial heterogeneity was present (I² = 79%), indicating variability across studies. Conclusions: Hypoalbuminemia showed a non-significant association with mortality in hemodialysis patients, though variability across studies suggests further research is needed for clarity.
Impact of Socioeconomic Inequalities on the Incidence of Type 2 Diabetes Mellitus: A Systematic Review Sasongko, Calvin; Adrya, Jessica; Varsha, Srigita; Fatchurrahman, Sony A.; Hermawan, Galih Muchlis; Dhika, Veriantara Satya; Tjahyanto, Teddy
Medicinus Vol. 15 No. 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i2.10972

Abstract

ckground: Type 2 diabetes mellitus (T2DM) is a rising global burden, and socioeconomic inequalities may shape risk through differential resources, environments, and access to prevention and care. We synthesised evidence on the association between socioeconomic position (SEP) and incident T2DM. Methods: We conducted a PRISMA 2020–guided systematic review of PubMed, EMBASE, and Scopus (inception to 18 January 2026). Observational studies of adults without diabetes at baseline that measured SEP (education, income, occupation and/or area deprivation) prior to diagnosis and reported incident T2DM were eligible. Random-effects meta-analyses pooled relative risks (RRs), treating hazard ratios as approximations. Risk of bias was assessed (NOS). Result: From 1,580 records, 25 studies met inclusion criteria and 23 contributed to quantitative synthesis. Studies were mainly prospective cohorts or nested case–control designs, largely from high-income countries, with follow-up from 3 to 34 years and participants aged 18–86 years. Lower education was associated with higher T2DM incidence (least vs most educated: RR 1.55, 95% CI 1.37–1.75). Lower occupational position was also associated with increased risk (lowest vs highest: RR 1.60, 95% CI 1.25–2.05). Income was not statistically conclusive (lowest vs highest: RR 1.37, 95% CI 0.94–2.01). Conclusions: Socioeconomic disadvantage, particularly lower education and occupational status, is consistently associated with higher risk of incident T2DM. Prevention and screening should incorporate SEP to better target upstream determinants.
Prognostic Significance of Hypoalbuminemia in Transcatheter Aortic Valve Implantation Patients: A Systematic Review and Meta Analysis of Diagnostic Test Accuracy Huvi, Destino; Adrya, Jessica; Sofyan, Nihal; Fauzi, Daffa Rizqi; Dharmasaputra, Alan; Varsha, Srigita; Wiyono, Putri Dhiya Prameswari
Medicinus Vol. 15 No. 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i2.10973

Abstract

ckground: Calcific aortic stenosis is common in older adults, and TAVR has expanded treatment to patients with high comorbidity and frailty. Serum albumin is an inexpensive marker that reflects inflammation, nutrition, and physiologic reserve, but its prognostic performance in TAVR needs clearer quantification. Methods: We performed a PRISMA/PRISMA-DTA–guided systematic review and diagnostic test accuracy meta-analysis of studies evaluating pre-procedural hypoalbuminemia in adults undergoing TAVR/TAVI. PubMed, Embase, and Scopus were searched from inception to 18 January 2026. Hierarchical models were used to pool sensitivity and specificity for 30-day mortality, and a random-effects model pooled hazard ratios for time-to-event mortality. Risk of bias was assessed using PROBAST. Result: Ten studies met inclusion criteria. Definitions of hypoalbuminemia varied (most commonly <3.3–3.5 g/dL). For predicting 30-day mortality, pooled sensitivity was 47.7% (95% CI 35.5–59.9) and pooled specificity was 76.0% (95% CI 62.9–89.2), indicating better rule-in than rule-out performance. Across studies reporting time-to-event outcomes, hypoalbuminemia was associated with higher mortality (pooled HR 1.15, 95% CI 1.03–1.29). PROBAST ratings were generally low risk for participants, predictors, and outcomes, with some concerns in the analysis domain. Conclusions: Pre-procedural hypoalbuminemia is a practical risk marker in TAVR patients, showing moderate specificity for early mortality and a consistent association with worse survival, supporting its use in peri-procedural risk stratification.
Co-Authors Andrean, Melvin Dharmasaputra, Alan Dhika, Veriantara Satya Fatchurrahman, Sony A. Fauzi, Daffa Rizqi Hermawan, Galih Muchlis Huvi, Destino Jayaningrat, Dewa Ayu Tri Kartadinata, Muhammad Faishal Moelyadi, Felly Mukti, A. Muh. Yasser Pake, Indry Agatha Rihi Putra, I Made Gede Dwipayana Putri, Syafira Ayudiah Syah Sasongko, Calvin Sofyan, Nihal Theis, Aveline Maisie Tjahyanto, Teddy Varsha, Srigita Wirawan, I Made Suma Wiyono, Putri Dhiya Prameswari