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All Journal Jurnal Abdi Inovatif : Pengabdian kepada Masyarakat Molekul: Jurnal Ilmiah Kimia
Hutagaol, Ricson Pemimpin
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Environmental Science Materials Science & Nanotechnology Social Sciences Other

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Cholestan Steroids from The Stem Bark of Aglaia angustifolia Miq and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell Lines Hutagaol, Ricson Pemimpin; Mozef, Tjandrawati; Fajriah, Sofa; Primahana, Gian; Supratman, Unang; Harneti, Desi; Hidayat, Ace Tatang; Awang, Khalijah; Shiono, Yoshihito
Molekul Vol 18 No 2 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.2.6205

Abstract

With about 120 species, Aglaia is one of the largest genera of the plant family Meliaceae (the mahogany plants). Various Aglaia species have been investigated since the 1960s for their phytochemical constituents and biological properties. This research objective was to find secondary metabolites that have activity as anti-breast cancer compounds from endemic Indonesian Aglaia, such as Aglaia angustifolia Miq. Two cholestan type steroids, stigmast-5en-3α-acetat (1), as a new steroid with α-sterochemistry of acetyl moiety at C-3 and 23a-homostigmast-5en-3β-ol (2), with unusual side chain were isolated for the first time from the stem bark of Aglaia angustifolia Miq or known as segara tree in Kalimantan. The chemical structures of two steroids were identified with spectroscopic data, including IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, NOESY, 1H-1H COSY) and HRTOF-MS, as well as by comparing with previously reported spectral data. These two steroids were isolated for the first time from this genus. Steroids 1 and 2 were evaluated for cytotoxic activity against MCF-7 breast cancer cells and showed weak activity with IC50 values of 829.0 and 903.0 µg/mL, respectively.
PENDAMPINGAN PRODUKSI YOGHURT UNTUK PENINGKATAN NILAI JUAL SUSU KELOMPOK TANI TERNAK SAPI (KTTSP) DESA SITU UDIK, CIBUNGBULANG, BOGOR Hutagaol, Ricson Pemimpin; Susanty, Devy; Rumna, Rumna; Widhyastini, I Gusti Ayu Manik; Wardhani, Gladys Ayu Paramita Kusumah; Oksari, Ade Ayu
Jurnal Abdi Inovatif : Pengabdian kepada Masyarakat Vol. 3 No. 2 (2024): Jurnal Abdi Inovatif : Pengabdian kepada Masyarakat
Publisher : Universitas Nusa Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31938/jai.v3i2.727

Abstract

The Bogor Regency dairy cattle livestock business area (KUNAK) is in Cibungbulang District, one of the livestock areas, and the product is cow's milk. The cow's milk produced is sold directly to consumers or milk producers. The selling value of fresh cow's milk is lower than processed cow's milk, and fresh cow's milk has the risk of being easily damaged, resulting in losses for farmers. This Community Service (PKM) activity aims to assist farmers in handling their processed milk production by making yogurt for the Cattle Farmers Group (KTTSP). The approach is in the form of an initial survey regarding partner problems, formulating solutions, providing assistance, and analyzing the partner's level of understanding. This community service activity results in an increase in partners' knowledge of dairy products and how to make them before and after the activity. Apart from that, partners can also increase the selling value of pure cow's milk through processed products in the form of yogurt with a delicious taste and attractive packaging, thereby increasing the selling value of the product.
Dammarane-Type Triterpenoids from Twigs of Aglaia Foveolata and Their Antibacterial Activity Hutagaol, Ricson Pemimpin; Mozef, Tjandrawati; Nurilmala, Febi; Primahana, Gian; Fajriah, Sofa; Prastya, Muhammad Eka; Hidayatullah, Sigit; Satyaningsih, Desy
Molekul Vol 20 No 2 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.2.16241

Abstract

ABSTRACT. The Aglaia species, which contains triterpenoids, is the most numerous in the Meliaceae family. Aglaia foveolata (A. foveolata) is a type of plant that has many benefits, as medicinal ingredients. The potential of this plant is inseparable from the content of various bioactive compounds. This study aims to isolate, characterize the active compound from the twigs of A. foveolata and test its activity as an antibacterial. Three dammarane-type triterpenoids were isolated from the A. foveolata twigs which is, namely dammar-24-en-3β,20-diol (1), an epimeric mixture of shoreic and eichlerianic acid (2, 3). Their chemical structures were determined based on spectroscopic data using infrared, high-resolution mass spectrometry, and including one and two-dimensional NMR techniques, as well as through data comparison of the reported compound. Compound 1 was reported for the first time to be successfully isolated from this species. All these substances were tested for the first time for their antibacterial activity against two Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis and two Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, through this study. Compound 1 was inactive, the epimeric mixture of 2 and 3 showed moderate antibacterial activity with a minimum inhibitory concentration (MIC) value ranging from 31.7 to 126.6 ppm, particularly against S. aureus with a MIC value of 31.7 ppm. Keywords: Aglaia, Elucidation, Isolation, Spectroscopy, Bacterial
Co-Authors Ace Tatang Hidayat Ade Ayu Oksari Desi Harneti Putri Huspa Devy Susanty Febi Nurilmala Gladys Ayu Paramita Kusumah Wardhani Hidayatullah, Sigit I Gusti Ayu Manik Widhyastini Khalijah Awang Prastya, Muhammad Eka Primahana, Gian Rumna, Rumna Satyaningsih, Desy Shiono, Yoshihito Sofa Fajriah Tjandrawati Mozef Unang Supratman