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All Journal HAYATI Journal of Biosciences Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Alchemy : Journal of Chemistry INDONESIAN JOURNAL OF PHARMACY Jurnal Kimia Riset Chimica et Natura Acta Indonesian Journal of Chemistry Pharmaceutical And Biomedical Sciences Journal (PBSJ) Molekul: Jurnal Ilmiah Kimia Jurnal Kefarmasian Indonesia
Sofa Fajriah
Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK Serpong, Banten
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Energy Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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MACARANGIN, A GERANYLATED FLAVONOID AND ANTICANCER ACTIVE COMPOUND ISOLATED FROM ETHYL ACETAT FRACTION OF Macaranga gigantifolia LEAVES Darmawan, Akhmad; Suwarso, Wahyudi P.; Kosela, Soleh; Kardono, Leonardus B.S.; Fajriah, Sofa
INDONESIAN JOURNAL OF PHARMACY Vol 26 No 1, 2015
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (705.678 KB) | DOI: 10.14499/indonesianjpharm26iss1pp52

Abstract

Macaranga known locally as mahang-mahangan has uniquely ecological function, and also became a part of traditional medicine in Indonesia. Macaranga genus also known as a sources of terpenoid and phenolic (flavonoid) compounds which have biological activity as antioxidant and anticancer (cytotoxicity).There are few phytochemical investigations have been done on M. gigantifolia species. As a part of our continuing research of isolation anticancer compound from natural product, a geranylated flavonoid compound (macarangin) has been isolated from ethyl acetate fraction of Macaranga gigantifolia leaves using chromatography methods. The isolated compund (isolat MG) was elucidated to gain the chemical structure based on spectroscopic data (LC-MS and FT-NMR). Cytotoxicity test of this compound was tested against MCF 7 cell lines, showed that macarangin has a potential activity with IC50 value 119.12μg/mL. Key words: Macarangin, geranylated  flavonoid, Macaranga gigantifolia, MCF 7 cell lines.
PENAPISAN FITOKIMIA DAN UJI TOKSISITAS DARI DAUN Myristica fatua HOUTT Fajriah, Sofa; Megawati, Megawati
Chimica et Natura Acta Vol 3, No 3 (2015)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (100.947 KB) | DOI: 10.24198/cna.v3.n3.9219

Abstract

Myristica fatua merupakan salah satu tumbuhan obat asli Indonesia yang berpotensi untuk dikembangkan. Telah dilakukan penapisan fitokimia dan uji toksisitas menggunakan metode BSLT (Brine Shrimp Lethality Toxicity) terhadap ekstrak metanol, ekstrak aseton dan etanol 70%. Selanjutnya ekstrak metanol difraksinasi untuk memperoleh fraksi n-heksana, etil asetat, dan n-butanol dari daun Myristica fatua Houtt dan dilakukan uji toksisitas lebih lanjut. Hasil penapisan fitokimia menunjukkan bahwa daun M. fatua mengandung senyawa terpenoid, steroid, flavonoid, saponin, dan tanin. Potensi antikanker juga ditunjukkan terhadap ekstrak metanol dan fraksi etil asetat yang mempunyai toksisitas paling tinggi dari fraksi lainnya dengan LC50 masing-masing adalah sebesar 64,57 dan 83,75 μg/mL.
Toxicity and Lethality Evaluations of Koordersiodendron pinnatum Leaves Methanolic Extract in DDY Mice Banjarnahor, Sofna Dewita Sari; Dewijanti, Indah Dwiatmi; Angelina, Marissa; Fajriah, Sofa
Journal of Tropical Life Science Vol 6, No 3 (2016)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.06.03.10

Abstract

The study of toxic features of Koordersiodendron pinnatum is vital for further studies of its pharmacological activities. Acute toxicity test was done on methanolic extracts of K. pinnatum in DDY mice. Animals were grouped into five: Group 1 was given 1 mL solution of 2.5% Tween 80 in a single oral dose; the remaining groups were orally given a single dose of 2, 4, 8 and 16 g/kg of K. pinnatum, respectively. Toxic effects of the extract were evaluated on the basis of behavioral observations in the form of locomotor activity; curiosity; defecation; urination and also animal mortality. Observations were carried out for 14 days. No significant changes on body weight, and behavioural activities were recorded. Mortality was recorded up to 2% of the male group, and no mortality within the female group. The extract is practically non toxic for both male and female (LD50>15 g/kg).
Apigenin, an Anticancer Isolated from Macaranga gigantifolia Leaves Fajriah, Sofa; Megawati, Megawati; Darmawan, Akhmad
Journal of Tropical Life Science Vol 6, No 1 (2016)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.06.01.02

Abstract

Apigenin, a flavonoid compound has been isolated from the ethyl acetate fraction of methanol extract of Macaranga gigantifolia leaves. Isolation and purification of apigenin conducted using chromatographic method, and chemical structure characterized based on spectroscopic data. In vitro anticancer activity test against murine leukemia P-388 cell line showed potential activity with IC50 14.13 μg/mL.Key words: apigenin, flavones, Macaranga gigantifolia, anticancer, murine leukemia P-388 cell line.
Toxicological Evaluation of Tetrameles nudiflora Methanolic Extract Banjarnahor, Sofna Dewita Sari; Dewijanti, Indah D; Angelina, Marissa; Megawati, Megawati; Fajriah, Sofa
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Exploration of Mekongga national park resulted in novel finding of anticancer property from Tetrameles nudiflora. The investigation of toxic features of T. nudiflora is vital for further studies of its pharmacological activities. Acute toxicity test was done on methanolic extracts of T. nudiflora in DDY mice. Animals were divided into 5 groups: Group 1 was given 1 ml solution of 2.5% Tween 80 in a single oral dose; Group 2, 3, 4 and 5 were orally administrated a single dose of 1, 2, 4 and 8 g/kg body weight T. nudiflora, respectively. Toxic effects of the extract were evaluated on the basis of behavioral observations in the form of locomotor activity; curiosity; defecation; urination and also animal mortality. Observations were carried out for 14 days. No significant changes on body weight, and behavioural activities were recorded. Mortality was recorded up to 22% of the male group, and 11% within the female group. The T.nudiflora extracts tested for toxicity against brine shrimp had 50% lethal concentration (LC50) values of 46.67 μg/ml. It can be concluded that methanol extracts of T. nudiflora are potential to be explored as anticancer (LC50=46.67 μg/ml). The extract is slightly toxic in male mice with Lethal Dose 50 (LD50) 12.6 g/kg body weight, and practically non toxic for female (LD50>15 g/kg body weight).Key words : Tetrameles nudiflora, brine shrimp lethality test, acute oral toxicity, LD 50.
Cholestan Steroids from The Stem Bark of Aglaia angustifolia Miq and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell Lines Hutagaol, Ricson Pemimpin; Mozef, Tjandrawati; Fajriah, Sofa; Primahana, Gian; Supratman, Unang; Harneti, Desi; Hidayat, Ace Tatang; Awang, Khalijah; Shiono, Yoshihito
Molekul Vol 18 No 2 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.2.6205

Abstract

With about 120 species, Aglaia is one of the largest genera of the plant family Meliaceae (the mahogany plants). Various Aglaia species have been investigated since the 1960s for their phytochemical constituents and biological properties. This research objective was to find secondary metabolites that have activity as anti-breast cancer compounds from endemic Indonesian Aglaia, such as Aglaia angustifolia Miq. Two cholestan type steroids, stigmast-5en-3α-acetat (1), as a new steroid with α-sterochemistry of acetyl moiety at C-3 and 23a-homostigmast-5en-3β-ol (2), with unusual side chain were isolated for the first time from the stem bark of Aglaia angustifolia Miq or known as segara tree in Kalimantan. The chemical structures of two steroids were identified with spectroscopic data, including IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, NOESY, 1H-1H COSY) and HRTOF-MS, as well as by comparing with previously reported spectral data. These two steroids were isolated for the first time from this genus. Steroids 1 and 2 were evaluated for cytotoxic activity against MCF-7 breast cancer cells and showed weak activity with IC50 values of 829.0 and 903.0 µg/mL, respectively.
The Sesquiterpenoids from the Stem Bark of Dysoxylum excelsum and Their Cytotoxic Activities against HeLa Cancer Cell Lines Supratman, Unang; Kautsari, Arsi; Naini, Al Arofatus; Riyadi, Sandra Amalia; Mayanti, Tri; Harizon, Harizon; Fajriah, Sofa
Molekul Vol 19 No 1 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.1.9406

Abstract

Sesquiterpenoids belong to a group of terpenoid compounds with interesting structures that are abundant in natural products especially in higher plants. Sesquiterpenoids have a wide variety of bioactivities with great potential cytotoxic activity. The species Dysoxylum excelsum belongs to the Meliaceae family known as higher plant, but only a few sesquiterpenoids have been reported particularly for their cytotoxic activity. Therefore, this research aims to isolate and elucidate the sesquiterpenoids structure from D. excelsum stem bark and examines their cytotoxicity against HeLa cervical cancer cells. Through various column chromatography separations, four known sesquiterpenes namely β-caryophyllene oxide (1), caryophyllenol II (2), humulene dioxide A (3), and guai-6-en-10β-ol (4) were acquired from the n-hexane extract. Compounds 1-4 were isolated for the first time from D. excelsum species. The sesquiterpenoid structures were elucidated according to Nuclear Magnetic Resonance, Infrared, and HR-TOF-MS analysis. The cytotoxicity compounds 1-4 was determined against HeLa cervical cancer cells by examination with the PrestoBlue method and compound 3 exhibited the most potent cytotoxicity with an IC50 value of 160.74 µM. Keywords: cytotoxic activity, Dysoxylum excelsum, HeLa, Meliaceae, sesquiterpenoid.
Sesquiterpenoids from The Stem Bark of Aglaia cucullata (Meliaceae) and Their Cytotoxic Activity Against A549 Lung Cancer Cell Lines Mustaqim, Iqbal Wahyu; Harneti, Desi; Naini, Al Arofatus; Hilmayanti, Erina; Darwati, Darwati; Nurlelasari, Nurlelasari; Mayanti, Tri; Maharani, Rani; Farabi, Kindi; Hidayat, Ace Tatang; Supratman, Unang; Fajriah, Sofa; Azmi, Mohamad Nurul; Shiono, Yoshihito
Molekul Vol 19 No 2 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.2.9823

Abstract

ABSTRACT. Sesquiterpenoids are a class of terpenoid compounds with a remarkable diversity of structures and biological activities. Sesquiterpenoids are primarily found in higher plants, such as the Meliaceae family's Aglaia genus. Aglaia cucullata is a species of Aglaia that is still rarely explored and can potentially contain sesquiterpenoid compounds with cytotoxic activity. Hence, the research intended to isolate sesquiterpenoids from the n-hexane extract of A. cucullata stem bark and evaluate their cytotoxic effect against A549 lung cancer cells. Compounds 1 and 2 were isolated and purified from n-hexane extracts utilizing various chromatographic techniques. The structure of compounds 1 and 2 was determined by analyzing various spectroscopic methods (IR, MS, and NMR) and comparing them to previously reported spectral data. Compound 1 was identified as an isodaucane-type sesquiterpenoid, 10-hydroxy-6,10-epoxy-7(14)-isodaucane, and was first reported in Meliaceae family. Compound 2 was confirmed as an eudesmane-type sesquiterpenoid, eudesm-4(15)-ene-1β,6α-dihydroxy, and was first reported in Aglaia cucullata. Cytotoxic activity of 1 and 2 were investigated in vitro against A549 lung cancer cells using the PrestoBlue assay and resulted in inactive and low cytotoxicity with IC50 values of 292.77 and 90.55 μM, respectively. Key words: Aglaia cucullata, , A549 cell lines, cytotoxic activity, Meliaceae, sesquiterpenoids.
Pengaruh Karbopol dan Propilen Glikol terhadap Laju Penetrasi Sediaan Emulgel Xanthone Rich Fraction dari Kulit Buah Manggis (Garcinia mangostana L.) Dahlizar, Sabrina; Alifia Agustina, Putri; Fitriana, Narti; Wira Septama, Abdi; Fajriah, Sofa; Herdini, Herdini
ALCHEMY:Journal of Chemistry Vol 11, No 2 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i2.20520

Abstract

Xanthone Rich Fraction (XRF) derived from mangosteen rind (G. mangostana L.) contains α-mangostin possessed antioxidant property. It may be used to prevent aging (anti-aging). This study aims to determine the effect of adding Carbopol as a gelling agent and propylene glycol as an enhancer on the physical characteristics and penetration rate of the emulgel. Four different formulas were prepared, F1 without a gelling agent (Carbopol) and enhancer (propylene glycol), F2 without a gelling agent (carbopol), F3 using a gelling agent (carbopol), and F4 using a gelling agent (carbopol) and enhancer (propylene glycol). The physical properties of formulas such as organoleptic examination, pH, viscosity, homogeneity, spreadability and cycling test were evaluated. Penetration testing was carried out using a Franz Diffusion cell. The results showed that F3 and F4 had the best physical stability and there was a difference in the penetration rate of α-mangostin from the four formulas. The amount of α-mangostin expanding the area for 6 hours, F1, F2, F3 and F4 were 228,22 µg/cm2; 251,06 µg/cm2(Tabel 3); 852,24 µg/cm2; dan 1.087,15 µg/cm2 respectively. The addition of a combination of Carbopol (gelling agent) and propylene glycol (enhancer) showed the highest penetration rate
Kandungan Fenolik dan Flavonoid Total Daun Macaranga hispida (Blume) Mull. Arg sebagai Kandidat Obat Antidiabetes Megawati, Megawati; Fajriah, Sofa; Supriadi, Edi; Widiyarti, Galuh
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 1, FEBRUARI 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i1.2846

Abstract

Diabetes Mellitus (DM) is one of the non communicable diseases (NCDs) with the largest number of deaths in the world. The Macaranga hispida (Blume) Mull. Arg is a source of phenolic compounds. Phenolic is grouped as polyphenols group that widely functioned as antidiabetic. The α-glucosidase enzyme plays a role in the forming of glycoproteins and glycolipids. The α-glucosidase enzyme can be used for antidiabetic activity assay because of its capability on breaking down carbohydrate into glucose in the human small intestine. This study aimed to determine phenolic content, total flavonoid content, and antidiabetic activity of M. hispida leaves extract and its fraction. The extract and fraction were tested for the phenolic levels using Folin-Ciocalteau method, the total flavonoid using alumunium chloride method, and the antidiabetic activity using α-glukosidase method. The yield of methanolic extract of the Macaranga hispida was 10.23%. Phenolic content of the ethyl acetate fraction from the methanolic extract was 8.411 mg, equivalent to gallic acid/100 mg extract. Total flavonoid content was 6.14 ± 0.31b/b μg/mL. Antidiabetic activity assay of the extract and the fractions of Macaranga hispida resulted the highest antidiabetic activity (IC50) was in the ethyl acetate fraction with IC50 value 21.91 μg / mL.
Co-Authors . Megawati A Darmawan Abdi Wira Septama Ace Tatang Hidayat Akhmad Darmawan Alifia Agustina, Putri Antonius Herry Cahyana Azmi, Mohamad Nurul Darwati Darwati Desi Harneti Putri Huspa Dewa Gede Katja Dewijanti, Indah Dwiatmi Eka Prasasti Nur Rachmani Farabi, Kindi Febi Nurilmala Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Galuh Widiyarti Gunawan, Latifah H Herdini Harizon Harizon Herdini Hidayatullah, Sigit Hilmayanti, Erina Hutagaol, Ricson Pemimpin Indah D Dewijanti, Indah D Isramiharti Isramiharti Kautsari, Arsi Khalijah Awang Kusumiyati Leonardus B.S. Kardono Lia Meilawati Maira, Faizah Marissa Angelina Maulina Handayani Megawati - Munfarikhatin, Atina Mustaqim, Iqbal Wahyu Mustofa, Hidayat Nurul Naini, Al Arofatus Narti Fitriana, Narti Nurlelasari Nurlelasari Ofa Suzanti Betha Prastya, Muhammad Eka Primahana, Gian PUJI LESTARI Putria, Devi Kasih Rani Maharani Rehana Romundza, Febbry Sabrina Dahlizar Sandra Amalia Riyadi Saputra, Ziyan Saputri, Ariyanti Sari, Aprilia Permata Satyaningsih, Desy Shiono, Yoshihito Sinaga, Siska Elisahbet Sofna Dewita Sari Banjarnahor, Sofna Dewita Sari Soleh Kosela Supriadi, Edi suryani, nelly Tjandrawati Mozef Tri Mayanti Unang Supratman Wahyudi P. Suwarso, Wahyudi P. Wira Septama, Abdi Yuni Anggraeni Zilhadia Zilhadia Zilhadia