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All Journal BIOEDUKASI Molekul: Jurnal Ilmiah Kimia
Kurniawati, Alfia Rahma
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Library & Information Science Materials Science & Nanotechnology

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Potential Endophytic Fungi from the Leaves of Syzygium zeylanicum (L.) and Their Secondary Metabolite Elfita, Elfita; Syarifah, Syarifah; Widjajanty, Hary; Setiawan, Arum; Kurniawati, Alfia Rahma
Molekul Vol 18 No 3 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.3.7881

Abstract

Endophytic fungi coexist without harms in the host in some parts or all parts of its lifecycle. Endophytic fungi excrete specialized bioactive compounds beneficial for of its host; the compound itself can be different from what can be found on their host. Endophytic fungi are capable to excrete biologically significant secondary metabolites acting as antidiabetic, antioxidant, antimicrobial, and cytostatic agents. Endophytic fungi existence are common across different plants; including Syzygium zeylanicum that can be found in Indonesia. This study aims to isolate endophytic fungi found in leaves of Syzygium zeylanicum, L., to elucidate their characterized morphologically, and to examine its antimicrobial and antioxidant properties in addition to their chemical structures. Characterization of endophytic fungi was conducted by their macroscopic and microscopic features, followed by molecular characterization of highly bioactive metabolites. Antimicrobial activities were measured by disc diffusion method. Antioxidant properties were measured with DPPH. Secondary metabolites were chromatographically isolated and identified with spectroscopy techniques (NMR ID and 2D). Four endophytic fungi isolates were obtained: Penicillium citrinum (SZ1), Colletotrichum lindemuthianum (SZ2), Aspergillus nidulan (SZ3), Scopulariopsis asperula (SZ4). Penicillium citrinum (SZ1) showed antimicrobial activities against four different bacteria (71.3% against E. coli; 74.1% against S. aureus; 76.2% against S. typhi; and dan76.9% against B. subtilis). Antioxidant activity ini all ekstrak of endophytic fungi showed very activity (IC50 SZ3 extract = 3.85 µg/mL). Potential endophytic fungi SZ1 was molecularly identified as Penicillium citrinum. Extracts from SZ1 fungi contains bioactive 4-hydroxy-2-(4-hydroxyphenyl)-ɣ-butyrolactone-3-yl) methyl acetate. The newly obtained substance could be developed into antimicrobial and antioxidant agents in further studies.
Bioactivity of Endophytic Fungi Fusarium brachygibbosum Isolated from the Stem of Avicennia marina as a Candidate for New Drug Source Oktiansyah, Rian; Noviyanto, Noviyanto; Iskandar, Damayanti; Nasution, Sakinah Salman Ahmad; Laksono, Pandu Jati; Kurniawati, Alfia Rahma; Pancasari, Adelia Rizki; Aputri, Farah Nuriessa; Yogyaswari, Sekar Ayoe
BIOEDUKASI: Jurnal Biologi dan Pembelajarannya Vol. 23 No. 3 (2025): Vol. 23, No. 3, October 2025
Publisher : PROGRAM STUDI PENDIDIKAN BIOLOGI FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UNIVERSITAS JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bioedu.v23i3.53787

Abstract

Indonesia's biodiversity holds significant potential as a source of medicinal compounds, one of which is Avicennia marina, known for its antioxidant and antibacterial properties. However, due to its protected conservation status, its utilization is limited. An alternative approach to harness its benefits is through symbiotic microorganisms such as endophytic fungi. This study aimed to isolate and evaluate the bioactivity of the endophytic fungus Fusarium brachygibbosum isolated from the stem of A. marina as a potential source of novel therapeutic agents. The methodology involved fungal isolation, morphological identification, and evaluation of antibacterial activity using the disc diffusion method and antioxidant activity using the DPPH assay. The results demonstrated that the obtained isolate (coded ADM2) exhibited strong antibacterial activity against Escherichia coli, Staphylococcus aureus, Salmonella typhi, and Bacillus subtilis. Moreover, the antioxidant assay of the ADM2 isolate revealed a very strong potential (IC50 < 20 µg/mL), indicating its potent ability to scavenge free radicals. Based on these findings and the literature on F. brachygibbosum, this species shows great potential as a source of bioactive compounds with medical applications, particularly in treating infections and preventing degenerative diseases. Further in vivo studies are necessary to confirm the therapeutic potential of this fungus as a safe and effective drug candidate.
Co-Authors Aputri, Farah Nuriessa Arum Setiawan Damayanti Iskandar Elfita Elfita Nasution, Sakinah Salman Ahmad Noviyanto Noviyanto, Noviyanto Oktiansyah, Rian Pancasari, Adelia Rizki Pandu Jati Laksono Syarifah Syarifah, Syarifah Widjajanty, Hary Yogyaswari, Sekar Ayoe