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All Journal Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Science and Technology Indonesia BIOEDUKASI Sainmatika: Jurnal Ilmiah Matematika dan Ilmu Pengetahuan Alam Konservasi Hayati JURNAL BIOSHELL Maximus: Journal of Biological and Life Sciences Life Science and Biotechnology Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Berita Biologi
Oktiansyah, Rian
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Mathematics Physics

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Antioxidant Activity of Endophytic Fungi Extract Isolated from Peel of Pineapple (Ananas comosus (L.) Merr. ‘Prabumulih’)) Oktiansyah, Rian; Hapida, Yustina; Risasti, Sinta
Sainmatika: Jurnal Ilmiah Matematika dan Ilmu Pengetahuan Alam Vol. 20 No. 2 (2023): Sainmatika : Jurnal Ilmiah Matematika dan Ilmu Pengetahuan Alam
Publisher : Universitas PGRI Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31851/sainmatika.v20i2.13270

Abstract

Pineapple (Ananas comosus (L.) Merr. 'Prabumulih') is a tropical fruit that is very popular for its unique aroma and sweet taste. It is also commonly believed that this fruit has potential applications in traditional medicine. However, the peel is not fully harnessed, despite its rich and intricate composition. This study presented findings regarding the endophytic fungi discovered within the peel of A comosus (L.) Merr. 'Prabumulih' and their performance as antioxidants. The endophytic fungal species were identified based on their morphological characteristics. The antioxidant assessment was carried out using the DPPH method. According to the findings of morphological identification, Trichoderma harzianum, an endophytic fungus, was found to exhibit the highest potential as an antioxidant source. Antioxidant activity showed a very strong category (IC50 = 18.74 µg/mL). Through the isolation of its pure constituents and subsequent in vivo testing, there is the potential for this extract from the endophytic fungus to evolve into an innovative source of antioxidants.
Antioxidant and Antibacterial Activity of Endophytic Fungi Isolated from Fruit of Sungkai (Peronema canescens) Oktiansyah, Rian; Widjajanti, Hary; Setiawan, Arum; Elfita
Science and Technology Indonesia Vol. 9 No. 1 (2024): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.1.17-27

Abstract

Peronema canescens, often known as sungkai, is widely used and can be found all around Indonesia. The public believes that the leaves may reduce fever and strengthen the immune system. However, the effectiveness of sungkai fruit has not been thoroughly investigated. In this research, we looked at endophytic fungus extracts from sungkai fruit’s that have antioxidant and antibacterial properties. The study’s results will serve as the foundation for further investigation into the development of potential natural chemicals with antioxidant and antibacterial properties. Morphologically, the endophytic fungi isolated from sungkai fruit were identified. The antioxidant and antibacterial properties of endophytic fungal extracts were studied using the DPPH technique and the paper disk diffusion method. By employing molecular identification and column chromatography to separate the active compounds, the most likely endophytic fungal isolates were found based on the results of the bioactivity tests. Using 1D NMR spectroscopic methods, the chemical’s structure was determined, and the results were compared to NMR data for the same compound published in the literature. Fruit of sungkai had 8 strains of endophytic fungus (RBH1-RBH8). Strong antibacterial and very strong antioxidant activity were shown by the RBH5 isolate (IC50 < 20 μg/mL). Pythium periplocum was determined to be the RBH5 isolate based on molecular testing. Pure chemical compound extracted from RBH5 isolates shown highly potent and potent antibacterial and antioxidant effects. The chemical compound was identified by spectroscopy as 3-hydroxy-4(hydroxy(4-hydroxyphenyl)methyl)-γ-butyrolactone. The results of this study serve as the foundation for developing compounds as pharmaceutical raw materials via further research phases.
Combination Effect of Extracts and Pure Compounds of Endophytic Fungi Isolated from Sungkai (Peronema canescens) Leaves on Antioxidant Activity Elfita; Oktiansyah, Rian; Mardiyanto; Setiawan, Arum; Widjajanti, Hary
Science and Technology Indonesia Vol. 9 No. 1 (2024): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.1.69-76

Abstract

Endophytic fungi extracts have various biological and pharmacological activities as natural antioxidants which have the potential to be developed in the pharmaceutical. Drugs made from natural substances frequently work best when they are present in large quantities. This may result in unfavorable side effects from using more of one substance at a time. This limitation can be overcome by using a combination of the extracts/pure compounds that allow synergistic interactions with strong antioxidant properties at fairly low concentrations. The purpose of this research was to determine the combined effect of endophytic fungi extracts and its pure compounds on their antioxidant activity. This research was initiated by rejuvenating eight selected endophytic fungal isolates from Sungkai leaves and morphological characterization was carried out. Each fungus was cultivated in PDB medium for 4 weeks under statistical conditions. Ethyl acetate was used to extract the endophytic fungi’s liquid culture, which was then evaporated. Each endophytic fungal extract (PD1-PD8) and their five pure compounds were tested for antioxidant activity by the DPPH method. Then a combination of two and three extracts was carried out with a ratio of 1:1. The results show that the interaction of the mixture of endophytic fungi extracts and their pure compounds can be classified as synergistic (combined effect of the extracts > individual effects), additive (combined effect of the extracts = individual effect), and nothing is antagonistic (combined effect of the extracts < individual effects). The best combination in this study was PD4+PD5+PD6 (1:1:1) which could be used as a formula for further research into in vivo immunostimulant tests. Another conclusion from this research is that the pure compounds contained in the extracts have lower antioxidant activity than the extracts and do not have a synergistic effect on the combination.
The Effect of Pangasius hypopthalmus Oil on the Memory of Mice (Mus musculus) Robiatun, Robiatun; Oktiansyah, Rian; Iktibar, Izon
JURNAL BIOSHELL Vol 14 No 2 (2025): Oktober
Publisher : Universitas Islam Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56013/bio.v14i2.4330

Abstract

Fish oil is an essential nutrient that is vital for the human body due to its content of saturated and unsaturated fatty acids, particularly omega-3. The Pangasius fish (Pangasius hypopthalmus) is known to have a relatively high content of omega-3 compared to other freshwater fish. Omega-3 fatty acids are crucial for neuronal growth, thereby influencing memory function. This study aimed to investigate the effect of Pangasius fish oil on the memory of mice (Mus musculus). The experimental design was a completely randomized design involving 24 mice, divided into six treatment groups (P0: Control, P1: 0.0016 ml/g weight/day, P2: 0.0033 ml/g weight/day, P3: 0.005 ml/g weight/day, P4: 0.0066 ml/g weight/day, P5: 0.0083 ml/g weight/day), with four repetitions for each treatment administered over seven days. The parameter observed was the number of mice that correctly explored all arms of the Y-maze. The observations indicated that fish oil has a tendency to influence the memory of mice.
Bioactivity of Endophytic Fungi Fusarium brachygibbosum Isolated from the Stem of Avicennia marina as a Candidate for New Drug Source Oktiansyah, Rian; Noviyanto, Noviyanto; Iskandar, Damayanti; Nasution, Sakinah Salman Ahmad; Laksono, Pandu Jati; Kurniawati, Alfia Rahma; Pancasari, Adelia Rizki; Aputri, Farah Nuriessa; Yogyaswari, Sekar Ayoe
BIOEDUKASI: Jurnal Biologi dan Pembelajarannya Vol. 23 No. 3 (2025): Vol. 23, No. 3, October 2025
Publisher : PROGRAM STUDI PENDIDIKAN BIOLOGI FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UNIVERSITAS JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bioedu.v23i3.53787

Abstract

Indonesia's biodiversity holds significant potential as a source of medicinal compounds, one of which is Avicennia marina, known for its antioxidant and antibacterial properties. However, due to its protected conservation status, its utilization is limited. An alternative approach to harness its benefits is through symbiotic microorganisms such as endophytic fungi. This study aimed to isolate and evaluate the bioactivity of the endophytic fungus Fusarium brachygibbosum isolated from the stem of A. marina as a potential source of novel therapeutic agents. The methodology involved fungal isolation, morphological identification, and evaluation of antibacterial activity using the disc diffusion method and antioxidant activity using the DPPH assay. The results demonstrated that the obtained isolate (coded ADM2) exhibited strong antibacterial activity against Escherichia coli, Staphylococcus aureus, Salmonella typhi, and Bacillus subtilis. Moreover, the antioxidant assay of the ADM2 isolate revealed a very strong potential (IC50 < 20 µg/mL), indicating its potent ability to scavenge free radicals. Based on these findings and the literature on F. brachygibbosum, this species shows great potential as a source of bioactive compounds with medical applications, particularly in treating infections and preventing degenerative diseases. Further in vivo studies are necessary to confirm the therapeutic potential of this fungus as a safe and effective drug candidate.
Bioactivity of Endophytic Fungal Extract Isolated from Purun (Eleocharis dulcis (Burm.f.) Trin. ex Hensch) Oktiansyah, Rian; Pratiwi, Mardiyah; Kharisma, Sully Pudja; Fauzan, Ahmad Rizki; Utami, Riza; Amelia, Dea; Noviyanto, Noviyanto; Nasution, Sakinah Salman Ahmad
Life Science and Biotechnology Vol. 2 No. 2 (2024): November 2024
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/lsb.v2i2.52579

Abstract

The study investigates the bioactivity of endophytic fungi isolated from Eleocharis dulcis (Burm.f.) Trin. ex Hensch., focusing on their potential as alternative sources of bioactive compounds. E. dulcis, a plant commonly found in wetland ecosystems, has traditionally been used for its medicinal properties. However, the massive extraction of the plant may lead to ecological imbalance, prompting the exploration of endophytic fungi as a sustainable alternative. The objective of this research is to isolate, identify, and evaluate the antimicrobial and antioxidant properties of endophytic fungi from Eleocharis dulcis. Endophytic fungi were isolated aseptically, followed by morphological identification. Antioxidant and antimicrobial assays were conducted to assess the bioactivity of the fungal extracts. Antioxidant activity was evaluated using the DPPH method, while antibacterial activity was assessed using the disc paper diffusion method. The results revealed that several isolates (from leaves: LP1 – LP6, from root: RP1 – RP3) exhibited significant antimicrobial activity against Escherichia coli and Staphylococcus aureus, with Penicillium spp. and Cladosporium spp. showing the highest levels of bioactivity. Additionally, all fungal isolates demonstrated very strong antioxidant activity, with most achieving an IC50 below 20 µg/mL. In conclusion, the findings suggest that endophytic fungi from E. dulcis represent a valuable source of bioactive compounds with potential applications in pharmaceuticals. Further research is required to isolate and characterize the active compounds, as well as to evaluate their efficacy through in vivo studies
Antibacterial and antioxidant activity of Endophytic Fungal Extract Isolated from the Root of Sonneratia caseolaris Noviyanto, Noviyanto; Oktiansyah, Rian; Nasution, Sakinah Salman Ahmad; Utami, Riza; Amelia, Dea
Life Science and Biotechnology Vol. 3 No. 1 (2025): May 2025
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sonneratia caseolaris is a mangrove species of considerable pharmacological importance; however, its natural populations are increasingly threatened by habitat degradation and overexploitation. Endophytic biotechnology provides a sustainable alternative for exploring the bioactive potential of this plant without imposing additional pressure on its fragile ecosystem. This study aimed to evaluate the antibacterial and antioxidant activities of endophytic fungal extracts isolated from the roots of S. caseolaris. Morphological and molecular techniques were employed for fungal identification, while antibacterial activity was assessed using the disc diffusion assay, and antioxidant capacity was evaluated through the DPPH radical scavenging assay. The selected fungal isolate, RSC2, exhibited strong antibacterial and antioxidant activities. Thin Layer Chromatography (TLC) analysis confirmed the presence of flavonoid compounds, and molecular identification verified the isolate as Aspergillus niger. This study reports, for the first time, the isolation of A. niger from S. caseolaris roots with the ability to produce flavonoid metabolites exhibiting notable bioactive potential. These findings provide a scientific basis for future in vivo investigations aimed at developing natural compounds from mangrove-associated endophytes as promising pharmaceutical candidates.
Detection of Salmonella sp. and Escherichia coli Contamination on Processed Fish Meat Putri, Monica Karunia; Oktari, Agung; Oktiansyah, Rian; Ulandari, Tiara
MAXIMUS: Journal of Biological and Life Sciences Vol. 1 No. 1 (2023)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/maximus.v1i1.1151

Abstract

Fish is a processed food ingredient with very high water content, causing fish to become perishable due to the growth of bacteria in fish. One of the foods made from processed fish is pempek. Therefore, carrying out excellent handling and processing of these processed food ingredients is necessary. This study aims to detect the presence of Salmonella sp bacteria with SSA (Salmonella Shigella Agar) media and E-coli with EMBA (Eosin Methylene Blue Agar) media in processed food derived from ground fish, namely pempek. Three samples were taken from several Palembang city snacks. The method used is a prediction test by streaking samples on selective media SSA and EMBA scratching. The results showed that all food samples tested to detect the presence of Salmonella sp. using SSA media showed positive results. The detection test results for the contamination of E-coli using EMBA media on the food samples also showed that three samples of pempek made from flour and processed ground fish meat positively contained E-coli bacteria.
Identifikasi Kualitas Air dan Pelatihan Teknik Penjernihan Air Sederhana di Desa Tanjung Menang, Kabupaten Ogan Komering Ilir Noviyanto, Noviyanto; Kurnia, Alfia Rahma; Aini, Kurratul; Hapida, Yustina; Oktiansyah, Rian; Nurokhman, Amin; Habisukan, Ummi Hiras; Anggun, Wicaksono
Agrokreatif: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 3 (2023): Agrokreatif Jurnal Ilmiah Pengabdian Kepada Masyarakat
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/agrokreatif.9.3.304-317

Abstract

Clean water is a basic need for society. However, the problem of clean water sources still occurs in the Ogan Komering Ilir (OKI) area of South Sumatra Province. The condition of the water being brownish and oily is an unresolved problem. One source that has the potential to disrupt water quality is the presence of factories around rivers. This community service activity aims to identify water quality and provide training to the community regarding river water management strategies and drilled wells as the primary water source for obtaining clean water, as well as increasing understanding and knowledge about clean water management with the Gravity-fed Filter Technique. The method of activities related to clean water quality is carried out in four stages, namely: 1) Location survey (cross-sectional), 2) Water sampling and laboratory analysis, 3) Education on water quality standards, and 4) Training on Gravity-fed Filter Techniques. The laboratory analysis showed that the water samples smelled fishy and were brownish and oily. In addition, the results of microbiological tests on water samples contained Coliform bacteria (sanitation indicator bacteria), which were outside the provisions of Minister of Health Decree No. 907/MENKES/SK/VII/2002 concerning clean water quality requirements. Through training activities using the Gravity-fed Filter technique, the pH and bacteria contained in the water can be reduced. Clean water management strategies using the Gravity-fed Filter technique can be used as a solution to improve clean water quality. Every society can apply the Gravity-fed Filter technique. Through this activity, society has managed water sources into clean water for daily needs.
Identifikasi Fungi Endofit yang Diisolasi dari Tanaman Jambu Monyet (Anacardium occidentale L.) pada Wilayah Kabupaten Banyuasin Habisukan, Ummi Hiras; Musyalina, Aisyah; Oktiansyah, Rian; Laksono, Pandu Jati
Konservasi Hayati Vol 19 No 1 (2023): APRIL
Publisher : Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/hayati.v19i1.26570

Abstract

Cashew fruit is a plant that is widely grown in eastern Indonesia, such as in NTB, Bali, NTT, South Sulawesi, and Southeast Sulawesi. The study aimed to identify the endophytic fungi found in cashew trees. The method used in this research was taking samples, namely the roots, root bark, stems, bark and leaves of the cashew plant then making instant PDA media mixed with distilled water and antibiotics with direct planting techniques on PDA in Petri dishes. Furthermore, the purification of endophytic fungi was carried out followed by macroscopic and microscopic observations by observing the types of spores, spore forms, and hyphae. The results of macroscopic and microscopic observations on samples of isolates coded KB.AO1 and D.AO1 were identified as belonging to the genus Fusarium, isolates coded KB.AO2 belonged to the genus Trichoderma, isolates coded A.AO1 belonged to the genus Colletotrichum, and isolate A.AO2 belonged to the genus Acremonium, isolate KB.AO1 belongs to the genus Cladosporium, code KB.AO2 belongs to Aspergillus, isolate code BAO1 belongs to Pythium, isolate code BAO2 belongs to Mucor, and isolate code DAO2 belongs to Nigrospora.
Co-Authors Anggun, Wicaksono Anjeli, Riri Aputri, Farah Nuriessa Armanda, Fahmy Arum Setiawan Damayanti Iskandar Dea Amelia, Dea Elfita Fauzan, Ahmad Rizki Febiantika, Imaniar Hary Widjajanti Hiras Habisukan, Ummi Iktibar, Izon Kharisma, Sully Pudja Kurnia, Alfia Rahma Kurniawati, Alfia Rahma Kurratul Aini, Kurratul Mardiyanto Musyalina, Aisyah Nasution, Sakinah Salman Ahmad Noviyanto Noviyanto Noviyanto, Noviyanto Nurokhman, Amin Octavia, Risky Oktari, Agung Pancasari, Adelia Rizki Pandu Jati Laksono Pratiwi, Mardiyah Putri, Monica Karunia Risasti, Sinta Riza Utami, Riza Robiatun, Robiatun Ulandari, Tiara Ummi Hiras Habisukan, Ummi Hiras Wicaksono, Anggun Yogyaswari, Sekar Ayoe Yustina Hapida, Yustina