Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Jurnal EduHealth PharmaCine : Journal of Pharmacy, Medical and Health Science
Lubis, Christina Febiola
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Studi Literatur : Kandidat Obat Baru Dan Target Kerja Obat Penyakit Systemic Lupus Erythematosus Aribowo, Audi Ichsani; Urbaningrum, Lestari Mahardika; Sa'adah, Cantika Nurul; Nur Annisa, Bunga; Sary, Nena Vauziah; Lubis, Christina Febiola; Nurfadhila, Lina; Utami, Marsah Rahmawati
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol 3 No 2 (2022): PharmaCine : Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v3i2.7973

Abstract

Latar Belakang: Systemic lupus erythematosus (SLE) ialah penyakit dengan kerusakan pada sistem kekebalan tubuh, terutama dalam imunitas seluler dan humoral. SLE terjadi pada individu dengan predisposisi genetik, terutama pada gen HLA yang dipicu oleh faktor lingkungan. Pada kebanyakan kasus, SLE muncul akibat efek dari banyak varian gen. Ada banyak golongan obat yang biasa digunakan untuk pengobatan SLE seperti kortikosteroid, imunosupresan, NSAID, atau antibodi monoklonal spesifik yang diarahkan terhadap reseptor permukaan sel atau sitokin  Tujuan: memberikan gambaran dan informasi terkini tentang kandidat obat baru dan target kerja obat penyakit lupus. Metode: studi tinjauan pustaka dari Google Scholar, Science Direct, dan PubMed dengan kriteria inklusi dan eksklusi. Hasil target kerja obat tersebut melalui tiga jenis penelitian berupa in vivo, in vitro, dan in silico. Berdasarkan tinjauan pustaka yang sudah dilakukan, terdapat beberapa target kerja obat pada penyakit lupus/SLE yaitu reseptor PI3Kδ, Enzim NF-κB inducing kinase, IFN-γ, IL-3, TNF-α, TP53, VEGFA, IL6, CD4, CCR1, JAK2, XRCC5, XRCC6, RB1, MYC, TP53, IL-1 alpha, IL-5, IL-6, IL-17, Limfotoxin-alpha, IL-21, TLR7, TLR9, CAPS3, STAT3, STAT1, IFNα, FcγR2A, CD22, CD20. Lalu untuk hasil beberapa kandidat obat baru terdapat pada ekstrak daun Bryophyllum pinnatum, curcumin, Langchuangding, Hedyotis diffusa Willd, dan BIIB059. Semua target atau kandidat senyawa pengobatan lupus yang diteliti memiliki hasil yang baik untuk pengobatan lupus. Kata Kunci : Kandidat Obat Baru, Target Kerja Obat, Systemic Lupus Erythematosus.
Standardization of Anthocyanin Compounds in Plants in Indonesia: Literature Review Agustin, Annastya Eka; Mierza , Vriezka; Annisa, Bunga Nur; Sa’adah, Cantika Nurul; Prasetyo, Fajar; Lubis, Christina Febiola
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (244.134 KB)

Abstract

Anthocyanins are secondary metabolites belonging to the flavonoid group which act as pigments or coloring agents in plants that give red, blue and purple colors to flowers, fruits and vegetables. Anthocyanins have several pharmacological activities such as antioxidants, anti-carcinogenic, preventing impaired liver function, anti-hypertensive, and anti-diabetic. The anthocyanin structure consists of an aglycone form which is sterified by several sugar groups (glycones) and acyl groups in several anthocyanin compounds. In an effort to maintain the standard of a drug made from natural ingredients, the process of standardization of active compounds can be carried out to guarantee and maintain safety, quality uniformity and efficacy. This review was conducted to identify the anthocyanins contained in an extract by means of thin layer chromatography (TLC), UV-Vis spectrophotometer, thin layer chromatography-densitometry, and high performance liquid chromatography (HPLC). The research methodology used is in the form of literature review with reference sources related to the review topic obtained from various sources, such as Pubmed, Science Direct, and Google Scholar.
Co-Authors Agustin, Annastya Eka Annisa, Bunga Nur Aribowo, Audi Ichsani Marsah Rahmawati Utami Mierza , Vriezka Nur Annisa, Bunga Nurfadhila, Lina Prasetyo, Fajar Sa'adah, Cantika Nurul Sary, Nena Vauziah Sa’adah, Cantika Nurul Urbaningrum, Lestari Mahardika