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All Journal Veterinary Biomedical and Clinical Journal Current Biomedicine
Purohita, Adwisto Saktika
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Efficacy of Shallots Infusion (Allium Cepa L.) as an Antidiarrhea in Mice (Mus Musculus) Purohita, Adwisto Saktika; Aulia Andi Mustika; Lina Noviyanti Sutardi; Fadholly, Amaq
Veterinary Biomedical and Clinical Journal Vol. 4 No. 2 (2022)
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.VetBioClinJ.2022.004.02.2

Abstract

Shallots have been used for generations as traditional medicine, one of which is used in the treatment of diarrhea. This study determined the antidiarrheal activity of the shallot bulbs using intestinal protection and intestinal transit methods, and to determine the effective concentration that gives the best antidiarrheal effect in mice. This study used thirty mice and divided into six groups. The negative control group was given Tween 80 (1%), positive control group was given Loperamide HCl, and four various concentrations of shallot infusion treatment groups (1.25%, 2.5%, 5%, and 10 %). The treatment was given by the oral route. The parameters used in the intestinal protection method were frequency of defecation and feces consistency, while in intestinal transit method the parameters used were the percentage ratio of the marker trajectories compared to the overall length of the intestine. The results showed that the 1.25% concentration of shallot infusion indicated the best antidiarrheal activity and had a smaller ratio or stronger inhibition to intestinal peristaltic compared to all other concentrations, 2.5%, 5%, dan 10%. We concluded that shallot bulbs infusion with a concentration of 1.25% has the most effective anti-diarrheal effect. This research can be continued by measurement of other diarrheal parameters such as stool weight, as well as start and stop time of diarrhea to further clarify the anti-diarrheal potential of shallot bulb infusion.
Antidiarrheal potential of Nigella sativa L. infusion in mice: a phytochemical and efficacy evaluation Safitri, Nadiya; Mustika, Aulia Andi; Pristihadi, Diah Nugrahani; Sutardi, Lina Noviyanti; Purohita, Adwisto Saktika
Current Biomedicine Vol. 3 No. 1 (2025): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.1.31

Abstract

Background Nigella sativa L., commonly known as black cumin, is a medicinal plant widely recognized for its therapeutic properties. However, limited pharmacological evidence supports its antidiarrheal potential when prepared as an infusion. Objective This study aimed to evaluate the phytochemical composition and antidiarrheal efficacy of Nigella sativa infusion in mice. Methods A total of 30 mice were divided into five groups: negative control (Tween 80 [1%]), positive control (Loperamide HCl), and treatment groups receiving Nigella sativa infusion at concentrations of 25%, 50%, and 100%. Antidiarrheal activity was assessed using the intestinal protection method, with parameters including defecation frequency, stool consistency, diarrheal onset time, and diarrheal duration. Results Phytochemical analysis revealed the presence of flavonoids, alkaloids, tannins, and saponins in Nigella sativa infusion. The infusion demonstrated significant antidiarrheal activity across all tested concentrations (25%–100%), with the 50% concentration showing the highest efficacy, comparable to Loperamide in reducing defecation frequency, improving stool consistency, delaying diarrheal onset, and shortening diarrheal duration. Conclusion Nigella sativa infusion at 50% concentration exhibits promising antidiarrheal potential and warrants further development as a herbal remedy.
Co-Authors Amaq Fadholly Aulia Andi Mustika Diah Nugrahani Pristihadi Lina Noviyanti Sutardi Safitri, Nadiya